Chemical Structural Biology and Drug Discovery of Targeted Protein Degradation
The Ciulli Laboratory develops novel small molecules inducing targeted protein degradation and modulating protein-protein interactions. We do research on fundamental chemical biology and translate it via collaboration partnership with the biopharma industry and by creation of spin-out companies. Pioneering discoveries…
New paper out in Nature Communications: Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2
We are excited to share our latest publication on the development of the first SOCS2 inhibitors | Just out in Nature Communications Our lab has worked relentlessly over many many years to develop phosphotyrosine-based covalent ligands of the E3 ligase SOCS2…
We report in ChemMedChem on our first ever EFMC short course on Targeted Protein Degraders
The 17th EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders Graphical Abstract The 17th EFMC Short Course on Medicinal Chemistry this year focused on Small Molecule Protein Degraders, and the opportunities and challenges that they present as a novel…
IMPRS-LM Student Symposium
Alessio was giving one of the plenary lectures at the IMPRS-LM Student Symposium
Our new paper on med chem optimization of the VHL inhibitors in collaboration with Michael Gütschow group at the University of Bonn is now published in J. Med. Chem.
We are happy to share our new publication on the structure-guided improvement of our von Hippel–Lindau (VHL) inhibitors | Just out ASAP in the Journal of Medicinal Chemistry We design a new di-Methyl analogue of VH101 (cmpnd 30) and qualify it as…
Dundee is UK’s best university for spinout success
The University of Dundee has been named the UK’s best for supporting spinout businesses, according to industry-leading analysis. The University of Dundee has been named the UK’s best for supporting spinout businesses, according to industry-leading analysis by Octopus Ventures. Companies…
Amphista contributes to Dundee being named as UK’s best university for spinout success
The University of Dundee has been named the UK’s best for supporting spinout businesses, according to industry-leading analysis. The University of Dundee has been named the UK’s best for supporting spinout businesses, according to industry-leading analysis by Octopus Ventures. Companies…
Alessio will be speaking on ‘Accelerating Drug Discovery’ – at the Braemar Summit 2023
‘Accelerating Drug Discovery’ – Braemar Summit 2023 A prestigious audience of policy makers, entrepreneurs and scientists from across the UK will hear about Dundee’s world-leading expertise in drug discovery at next month’s Braemar Summit. Dundee is the partner university of…
Daniel Johnson MSP visited the Centre
This Tuesday, Daniel Johnson MSP visited the Centre. The visit went extremely well where Daniel and his colleagues asked Alessio lots of questions about the research!
CeTPD Open Day – 23 September 2023 (10:00 – 14:00)
The Centre for Targeted Protein Degradation (CeTPD) is a new facility in the University of Dundee’s life sciences complex, housing world class research in targeted protein degradation. We are home to ~70 researchers and staff and have research in many…