Check our latest paper published in Angewandte. Closing the circle: A macrocyclic PROTAC has been designed and synthesized by adding a cyclizing linker to MZ1, a PROTAC targeting the bromodomain of the BET protein, Brd4. A co‐crystal structure of macroPROTAC‐1…
School of Life Science’s Professor Alessio Ciulli was amongst a selected group of world’s leading expert scientists and key opinion leaders who spoke at the Galien Forum on October 24, 2019, at the Alexandria Center in New York City. Alessio’s…
Alessio and Will both spoke at the 2nd Targeted Protein Degradation Summit in Boston. Read more about the 2nd Targeted Protein Degradation Summit. The meeting was held in Boston during 22-24 October 2019
Ciulli Lab reveals how the E3 ligase SOCS2 latches on to its protein substrates. Read full article on Nature Communications website. Read University of Dundee press release: “Ciulli Lab reveals how the E3 ligase SOCS2 latches on to its protein…
Congratulations to Guilherme for successfully defending his PhD thesis viva today!
You can view Will’s presentation during the webinar on YouTube or TOCRIS website.
Congratulations to Hannah in Dario Alessi’s group for the great job on this study. Well done Andrea for the compound design and synthetic contributions to the project! Read the open access article Title: Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC…
Well done Chiara! Read the full article. Authors: Chiara Maniaci and Alessio Ciulli* Title: Bifunctional chemical probes inducing protein-protein interactions. Abstract Inducing biomolecular interactions with synthetic molecules to impact biological function is a concept of enormous appeal. Recent years have seen…
University of Dundee and Eisai enter partnership for cancer drug discovery using targeted protein degradation. Read the full press release from Eisai Related links Eisai PR: EISAI ENTERS INTO COLLABORATION RESEARCH AGREEMENT WITH UNIVERSITY OF DUNDEE ON TARGETED PROTEIN DEGRADATION…
Alessio delivers one of the plenary lectures at the XXVI National Meeting in Medicinal Chemistry (NMMC 2019) in Milan, Italy. Read more about conference in the ChemMedChem’s Editorial: “Overview of the XXVI National Meeting in Medicinal Chemistry” by Prof. Marina Carini and Prof.…