NMR approaches in structure-based lead discovery for targeting multi-protein complexes

Category:2014, News
ByUoD Web Team
On27 Aug 2014

Our review on NMR approaches in structure-based lead discovery for targeting multi-protein complexes is now published in Prog. Biophys. Mol. Biol.

You can read our paper open-access .

Figure 1. Representative NMR techniques used for hit generation

Figure 2. Schematic representation of the stepwise approach of SAR by NMR

Figure 3. NMR techniques used to study ligand-bound conformation and protein binding sites identification

Figure 4. Isotopic labelling strategies to aid NMR studies of multi-protein targets.

Figure 5. Different labelling schemes and respective spectra in von Hippel-Lindau protein (pVHL) E3 ubiquitin ligase multi-subunit complex