Chemical genetics bump-and-hole approach to engineer controlled selectivity of BET bromodomain inhibitors

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A one day symposium for the Scottish cryo-EM community took place on 30 November 2023 The First Scottish cryo-EM symposium attracted over 90 participants from across academia and industry.  The event provided…

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On Thursday 23rd November Alessio joined David McBeth, VP for Entreprise and Economic Transformation at Dundee, and colleagues from the University’s RIS and Amphista therapeutics in Leeds city centre for…

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‘Trojan Horse’ chemical tool allows researchers to target ‘undruggable’ proteins University of Dundee researchers have developed a new molecule that is able to target and bind to a protein class…

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The University of Dundee has today (Oct 26, 2023) celebrated the official opening of its multi-million pound Centre for Targeted Protein Degradation (CeTPD), by UK Science Minister George Freeman who…

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The Ciulli Laboratory develops novel small molecules inducing targeted protein degradation and modulating protein-protein interactions. We do research on fundamental chemical biology and translate it via collaboration partnership with the…

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We are excited to share our latest publication on the development of the first SOCS2 inhibitors | Just out in Nature Communications Our lab has worked relentlessly over many many years…

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