Our paper on the molecular recognition of helical histone tail by PHD finger domains is now published in Biochemical Journal. Well done to Alessio B., Anastasia, Xavi – and Manuel! Read the full paper open access.
Our paper reporting the first ternary crystal structure of a PROTAC bound to to its E3 ligase VHL and Brd4 target is now published in Nature Chemical Biology! Our work provides unprecedented insights into how PROTACs work. Congratulations to Morgan, Andrea, Xavi and Kwok-Ho for a…
Our review on recognition and small-molecule mimicry of degrons by E3 ligases is now published in Current Opinion in Structural Biology. Well done Xavi! Read our review. Highlights: Abstract The ubiquitin–proteasome system is a master regulator of protein homeostasis, by…
The article is a contribution to the journal’s Special Issue for the 2018 Tetrahedron Young Investigators Award for Matthew Fuchter. Read our article Open Access Congratulations Pedro and Xavi, well done! The article is a contribution to the journal’s Special…
Read our Open Access article Congratulations to Anastasia, Xavi and colleagues! Read our Open Access article Congratulations to Anastasia, Xavi and colleagues!
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Read our paper open access here. The article will be published as part of the a Special Issue on “Inducing Protein Degradation as a Therapeutic Strategy“.
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The article will be part of the journal Special Issue on “Inducing Protein Degradation as a New Therapeutic Strategy”, edited by Prof. Craig Crews and Prof. Shameng Wang. Read our article Open Access