Publications from Professor Chris Abell and Professor Tom L. Blundell
31. Macaulay, K.M., Heath, G.A., Ciulli, A., Murphy, A.M., Abell, C., Carr, J.P., Smith, A.G.
The biochemical properties of the two Arabidopsis thaliana isochorismate synthases.
Biochem. J. 2017, 474 (10), 1579-1590
30. Hung, A.W., Silvestre, H.L., Wen, S., George, G.P.C., Boland, J., Blundell, T.L., Ciulli, A., Abell, C.
Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis
ChemMedChem 2016, 11(1), 38-42
- Selected as a “Very Important Paper” (VIP) by the Editors of ChemMedChem
29. Silvestre, H.L., Blundell, T.L., Abell, C., Ciulli, A.*
Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery.
Proc. Natl. Acad. Sci. U.S.A. 2013, 110 (32), 12984-12989
- Highlighted in Nature Chemical Biology
- Highlighted in Practical Fragments
- Highlighted in the Faculty of 1000Prime
28. Hudson, S.A., McLean, K.J., Surade, S., Yang, Y.-Q., Leys, D., Ciulli, A., Munro, A.W., Abell, C.
Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121.
Angew. Chem. Int. Ed. 2012, 51, 9311–9316
- Highlighted in Practical Fragments
27. Dias, M.V.B., Snee, W.C., Bromfield, K.M., Payne, R.J., Palaninathan, S.K., Ciulli, A., Howard, N.I., Abell, C., Sacchettini, J.C., Blundell, T.L.
Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis.
Biochem. J. 2011, 436 (3), 729–39
26. Śledź, P., Silvestre, H.L., Hung, A.W., Ciulli, A., Blundell, T.L., Abell, C.
Optimization of the Interligand Overhauser Effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase.
J. Am. Chem. Soc. 2010, 132, 4544–4545
- Highlighted in Practical Fragments
25. Scott, D.E., Dawes, G.J., Ando, M., Abell, C.*, Ciulli, A.*
A fragment-based approach to probing adenosine recognition sites using dynamic combinatorial chemistry.
ChemBioChem 2009, 10, 2772–2779
24. Hung, A.W., Silvestre, H.L., Wen, S., Ciulli, A., Blundell, T.L., Abell, C.
Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase.
Angew. Chem. Int. Ed. 2009, 48, 8452–8456
- Highlighted in Practical Fragments
23. Ciulli, A.*, Scott, D.E., Ando, M., Reyes, F., Saldanha, S.A., Tuck, K.L., Chirgadze, D.Y., Blundell, T.L., Abell, C.*
Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.
ChemBioChem 2008, 9, 2606–2611
22. Ciulli, A., Abell, C.
Fragment-based approaches to enzyme inhibition.
Curr. Opin. Biotech. 2007, 18 (6), 489–496
21. Scott, D.E., Ciulli, A., Abell, C.
Coenzyme biosynthesis: enzyme mechanism, structure and inhibition.
Nat. Prod. Rep. 2007, 24, 1009–1026
20. Ciulli, A., Blundell, T.L., Abell, C.
Fragment-based approaches to inhibitor discovery: targeting cofactor-binding sites and protein-protein interactions