Papers 2018

2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease. Thomas, M. G.; De Rycker, M.; Cotillo Torrejon, I.; Thomas, J.; Riley, J.; Spinks, D.; Read, K. D.; Miles, T. J.; Gilbert, I. H.; Wyatt, P. G. Bioorg. Med. Chem. Lett.; 2018, in press. PMID: 30104093

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis. Wyllie, S.; Thomas, M.; Patterson, S.; Crouch, S.; De Rycker, M.; Lowe, R.; Gresham, S.; Urbaniak, M. D.; Otto, T. D.; Stojanovski, L.; Simeons, F. R. C.; Manthri S1, MacLean LM1, Zuccotto F1, Homeyer N1, Pflaumer H7, Boesche M7, Sastry L1, Connolly, P.; Albrecht, S.; Berriman, M.; Drewes, G.; Gray, D. W.; Ghidelli-Disse, S.; Dixon, S.; Fiandor, J. M.; Wyatt, P. G.; Ferguson, M. A. J.; Fairlamb, A. H.; Miles, T. J.; Read, K. D.; Gilbert, I. H. Nature, 2018, 560, 192-197. PMID: 30046105

Challenges and recent progress in drug discovery for tropical diseases. De Rycker, M.; Baragana, B.; Duce, S. L.; Gilbert, I. H. Nature, 2018, 559, 498-506.

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals. Wall, R. J.; Moniz, S.; Thomas, M. G.; Norval, S.; Ko, E. J.; Marco, M.; Miles, T. J.; Gilbert, I. H.; Horn, D.; Fairlamb A. H.; Wyllie S. Antimicrob. Agents Chemother. 2018, 62, xxx-xxx. PMID: 29844044

Exhaustive sampling of the fragment space associated to a molecule leading to the generation of conserved fragments. Heikamp, K.; Zuccotto, F.; Kiczun, M.; Ray, P. Gilbert, I. H. Chem. Biol. Drug Des. 2018, 91, 655-667.