Papers 2011

Investigation of copper(II) tetrafluoroborate catalysed epoxide opening. Capes, A. S.; Crossman, A. T.; Webster, L. A.; Ferguson, M. A. J.; Gilbert, I. H. Tetrahedron Lett. 2011, 52, 7091-7094.   pubmed journal

Identification of Inhibitors of the Leishmania cdc-Related Protein Kinase CRK3. Cleghorn, L. A. T.; Woodland, A.; Collie, I. T.; Torrie, L. S.; Norcross, N.; Luksch, T.; Mpamhanga, C.; Walker, R. G.; Mottram, J. C.; Brenk, R.; Frearson, J. A.; Gilbert, I. H.; Wyatt, P. G. ChemMedChem, 2011, 6, 2214-2224.   pubmed journal

Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488. Smith, V. C.; Cleghorn, L. A. T.; Woodland, A.; Spinks, D.; Hallyburton, I.; Collie, I. T.; Mok, N. Y.; Norval, S.; Brenk, R.; Fairlamb, A. H.; Frearson, J. A.; Read, K. D.; Gilbert, I. H.; Wyatt, P. G. ChemMedChem, 2011, 6, 1832-1840.   pubmed journal

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis and Characterization of their Binding Mode by Protein Crystallography. Patterson, S.; Alphey, M. S.; Jones, D. C.; Shanks, E. J.; Street, I. P.; Frearson, J. A.; Wyatt, P. G.; Gilbert, I. H.; Fairlamb, A. H. J. Med. Chem., 2011, 54, 6514-6530.   pubmed journal

Design, Synthesis and Evaluation of 5’-Diphenyl Nucleoside Analogues as Inhibitors of the Plasmodium falciparum dUTPase. Hampton, S. E.; Baragana, B.; Schipani, A.; Bosch-Navarrete, C.; Musso-Buendia, J. A.; Recio, E.; Kaiser, M.; Whittingham, J. L.; Roberts, S. M.; Shevtsov, M.; Brannigan, J. A.; Kahnberg, P.; Brun, R.; Wilson, K. S.; Gonzalez-Pacanowska, D.; Johansson, N. G.; Gilbert, I. H. ChemMedChem, 2011, 6, 1816-1831.   pubmed journal

Site-directed mutagenesis provides insights into the selective binding of trityl derivatives to Plasmodium falciparum dUTPase. Recio, E.; Musso-Buendia, A.; Vidal, A. E.; Ruda, G. F.; Kasinathan, G.; Nguyen, C.; Ruiz-Perez, L. M.; Gilbert, I. H.; Gonzalez-Pacanowska, D. Eur. J. Med. Chem., 2011, 46, 3309-3314.   pubmed journal

Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis, Ishida, K.; Rodgrigues, J. C. F.; Cammerer, S.; Urbina, J. A.; Gilbert, I. H.; de Souza, W.; Rozental, S. Annals of Clinical Microbiology and Antimicrobials, 2011, 10, 3.   pubmed journal

Finding new hits in neglected disease projects: target or phenotypic based screening? Gilbert, I. H.; Leroy, D.; Frearson, J. A. Curr. Top. Med. Chem., 2011, 11, 1284-1291.   pubmed journal

Target validation: linking target and chemical properties to desired product profiles. Wyatt, P. G.; Gilbert, I. H.; Read, K. D.; Fairlamb, A. H. Curr. Top. Med. Chem., 2011, 11, 1275-1283.   pubmed journal

Beta-Branched Acyclic Nucleoside Analogues as Inhibitors of Plasmodium falciparum dUTPase. Baragana, B.; McCarthy, O.; Sanchez, P.; Bosch-Navarrete, C.; Kaiser, M.; Brun, M.; Whittingham, J. L.; Roberts, S.; Zhou, X.-X.; Wilson, K. S.; Johansson, N. G.; Gonzalez-Pacanowska, D.; Gilbert, I. H. Bioorg. Med. Chem., 2011, 19, 2378-2391.   pubmed journal

Modified 5’-Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase. Ruda, G. F.; Nguyen, C.; Ziemkowski, P.; Felczak, K.; Kasinathan, G.; Musso-Buendia, A.; Sund, C.; Zhou, X. X.; Kaiser, M.; Ruiz-Perez, L.-M.; Brun, R.; Kulikowski, T.; Johansson, N. G.; Gonzalez-Pacanowska, D.; Gilbert, I. H. ChemMedChem, 2011, 6, 309-320.   pubmed journal

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1. Spinks, D.; Ong, H. B.; Mpamhange, C. P.; Shanks, E. J.; Robinson, D. A.; Collie, I. T.; Read, K. D.; Frearson, J. A.; Wyatt, P. G.; Brenk, R.; Fairlamb, A. H.; Gilbert, I. H. ChemMedChem, 2011, 6, 302-308.   pubmed journal

Evaluation of three novel azasterols against Toxoplasma gondii. Martins-Duarte, E. S.; Lemgruber, L.; Orenes Lorente, S.; Gros, L.; Magaraci, F.; Gilbert, I. H.; de Souza, W.; Vommaro, R. C. Vet. Parasitol. 2011, 177, 157-161.   pubmed journal

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