Papers 2007

Synthesis and testing of peptides for anti-prion activity. Sellarajah, S.; Boussard, C.; Lekishvili, T.; Brown, D. R.; Gilbert, I. H. Eur. J. Med. Chem., 2008, 43, 2418-2427. link to journal abstract in pubmed link to the journal where paper was published

Lessons learnt from assembling screening libraries for drug discovery for neglected diseases. Brenk, R.; Schipani, A.; James, D.; Krasowski, A.; Gilbert, I. H.; Frearson, J. A.; Wyatt, P. G. ChemMedChem, 2008, 3, 435-444. link to journal abstract in pubmed link to the journal where paper was published

Target assessment for antiparasitic drug discovery. Frearson, J. A.; Wyatt, P. G.; Gilbert, I. H.; Fairlamb, A. H. Trends Parasitol., 2007, 23, 589-595. link to journal abstract in pubmed link to the journal where paper was published

Mechanistic Insights into the Cure of Prion Disease by Novel Antiprion Compounds. Webb, S.; Lekishvili, T.; Loeschner, C.; Sellarajah, S.; Prelli, F.; Wisniewski, T.; Gilbert, I. H.; Brown, D. R. J. Virol., 2007,.81, 10729-10741. link to journal abstract in pubmed link to the journal where paper was published

Azasterols impair Giardia lamblia proliferation and induces encystation. Maia, C.; Attias, M.; Urbina, J. Gilbert, I.; Magaraci, F.; de Souza, W. Biochemical and Biophysical Research Communications, 2007, 363, 310-316. link to journal abstract in pubmed link to the journal where paper was published

Quinuclidine Derivatives as Potential Anti-parasitics. Cammerer, B. B.; Jimenez, C.; Jones, S.; Gros, L.; Orenes Lorente, S.; Rodrigues, C.; Rodrigues, J. C. F.; Caldera, A.; Ruiz-Perez, L. M.; da Souza, W.; Kasier, M.; Brun, R.; Urbina, J. A.; Gonzalez Pacanowska, D.; Gilbert, I. H. Antimicrob. Agents. Chemother., 2007, 51, 4049-4061. link to journal abstract in pubmed link to the journal where paper was published

Alterations on the growth and ultrastructure of Leishmania chagasi induced by squalene synthase inhibitors. Granthon, A. C.; Braga, M. V.; Rodrigues, J. C.; Cammerer, S.; Lorente, S. O.; Gilbert, I. H.; Urbina, J. A.; de Souza, W. Vet Parasitol., 2007, 146, 25-34. link to journal abstract in pubmed link to the journal where paper was published

Synthesis and Biological Evaluation of Phosphate Prodrugs of 4-Phospho-d-erythronohydroxamic Acid, an Inhibitor of 6-Phosphogluconate Dehydrogenase. Ruda, G. F.; Alibu, V. P.; Mitsos, C.; Bidet, O.; Kaiser, M.; Brun, R.; Barrett, M. P.; Gilbert, I. H. ChemMedChem, 2007, 2, 1169-1180. link to journal abstract in pubmed link to the journal where paper was published

Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives. Sealey-Cardona, M.; Simon Cammerer, C.; Jones, S.; Ruiz-Pérez, L. M.; Brun, R.; Gilbert, I. H.; Urbina, J. A.; González-Pacanowska, D. Antimicrob. Agents Chemother., 2007, 51, 2123-2129. link to journal abstract in pubmed link to the journal where paper was published

Inhibitors of Trypanosoma brucei 6-Phosphogluconate Dehydrogenase, Hanau, S.; Montin, K.; Gilbert, I. H.; Barrett, M. P.; Dallocchio, F. Current Bioactive Compounds, 2007, 3, 161-169. link to the journal where paper was published

Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates. Sundaramoorthy, R.; Iulek, J.; Barrett, M. P.; Bidet, O.; Ruda, G. F.; Gilbert, I. H.;  Hunter, W. N. FEBS J., 2007, 274, 275-286. link to journal abstract in pubmed link to the journal where paper was published

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