Papers 2013

Handling uncertainty in dynamic models: the pentose phosphate pathway in Trypanosoma brucei. Kerkhoven, E.J.; Achcar, F.; Alibu, V. P.; Burchmore, R. J; Gilbert, I. H.; Trybiło, M.; Driessen, N. N.; Gilbert, D.; Breitling, R.; Bakker, B. M.; Barrett, M. P. PLoS Comput. Biol., 2013, 9, e1003371. link to journal abstract in pubmed

Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design. Pizarro, J.; Hills, T.; Senisterra, G.; Wernimont, A.; MacKenzie, C. J.; Norcross, N.; Ferguson, M. A. J.; Wyatt, P. G.; Gilbert, I. H.; Hui, R. Plos. Negl. Trop. Dis. 2013, 7, e2492. link to journal abstract in pubmed

Drug Discovery for Neglected Diseases: Molecular Target-Based and Phenotypic Approaches, Gilbert, I. H. J. Med. Chem., 2013, 56, 7719-7726. link to journal abstract in pubmed

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor. Kahsai, A. W.; Wingler, L. M.; Zhu, X.; Tripathi-Shukla, P.; Huang, X.-P.; Riley, J.; Besnard, J.; Read, K. D.; Roth, B. L.; Gilbert, I. H.; Hopkins, A. L.; Lefkowitz, R. J.; Navratilova, I. ACS Med. Chem. Lett., 2013, 4, 1005-1010. link to journal abstract in pubmed

Structure-Activity Relationship Studies of Pyrrolone Antimalarial Agents. Murugesan, D.; Kaiser, M.; White, K. L.; Norval, S.; Riley, J.; Wyatt, P. G.; Charman, S. A.; Read, K. D.; Yeates, C.; Gilbert, I. H. ChemMedChem, 2013, 8, 1537-1544. link to journal abstract in pubmed

Investigation of acyclic uridine amide and 5’-amido nucleoside analogues as potential inhibitors of the Plasodium falciparum dUTPase. Hampton, S. E.; Schipani, A.; Bosch-Navarrete, C.; Recio, E.; Kaiser, M.; Kahnberg, P.; González-Pacanowska, D.; Johansson, N. G.; Gilbert, I. H. Bioorg. Med. Chem., 2013, 21, 5876-5885. link to journal abstract in pubmed link to the journal where paper was published

Fragment-based hit identification: thinking in 3D. Morley, A. D.; Pugliese, A.; Birchall, K.; Bower, J.; Brennan, P.; Brown, N.; Chapman, T.; Drysdale, M.; Gilbert, I. H.; Hoelder, S.; Jordan, A.; Ley, S. V.; Merritt, A.; Miller, D.; Swarbrick, M. E.; Wyatt, P. G. Drug Discov Today. 2013, 18, 1221-1227. link to journal abstract in pubmed link to the journal where paper was published

From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti-Trypanosoma brucei Drug Discovery Lead Molecules. Woodland A, Grimaldi R, Luksch T, Cleghorn LA, Ojo KK, Van Voorhis WC, Brenk R, Frearson JA, Gilbert IH, Wyatt PG. ChemMedChem. 2013 Jul;8(7):1127-37.   pubmed  journal

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay. De Rycker M, Hallyburton I, Thomas J, Campbell L, Wyllie S, Joshi D, Cameron S, Gilbert IH, Wyatt PG, Frearson JA, Fairlamb AH, Gray DW. Antimicrob Agents Chemother. 2013 Jul;57(7):2913-22.   pubmed  link to the journal where paper was published

Discovery and structure-activity relationships of pyrrolone antimalarials. Murugesan D, Mital A, Kaiser M, Shackleford DM, Morizzi J, Katneni K, Campbell M, Hudson A, Charman SA, Yeates C, Gilbert IH. J Med Chem. 2013 Apr 11;56(7):2975-90.   pubmed  journal

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