Papers 2016

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy. Baragaña, B.; Norcross, N. R.; Wilson, C.; Porzelle, A.; Hallyburton, I.; Grimaldi, R.; Osuna-Cabello, M.; Norval, S.; Riley, J.; Stojanovski, L.; Simeons, F. R., Wyatt, P. G.; Delves, M. J.; Meister, S.; Duffy, S.; Avery, V. M.; Winzeler, E. A.; Sinden, R. E.; Wittlin, S.; Frearson, J. A.; Gray, D. W.; Fairlamb, A. H.; Waterson, D.; Campbell, S. F.; Willis, P.; Read, K. D.; Gilbert, I. H. J. Med. Chem., 2016, 59, 9672-9685. PMCID: PMC5108032

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials. Norcross, N. R.; Baragaña, B.; Wilson, C.; Hallyburton, I.; Osuna-Cabello, M.; Norval, S.; Riley, J.; Stojanovski, L.; Simeons, F. R.; Porzelle, A.; Grimaldi, R.; Wittlin, S.; Duffy, S.; Avery, V. M.; Meister, S.; Sanz, L.; Jiménez-Día, B.; Angulo-Barturen, I.; Ferrer, S.; Martínez, M. S.; Gamo, F. J.; Frearson, J. A.; Gray, D. W.; Fairlamb, A. H.; Winzeler, E. A.; Waterson, D.; Campbell, S. F.; Willis, P.; Read, K. D.; Gilbert, I. H. J Med Chem., 2016, 59, 6101-6120. PMCID: PMC4947981

Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi. Herrera, L. J.; Brand, S.; Santos, A.; Nohara, L. L.; Harrison, J.; Norcross, N. R.; Thompson, S.; Smith, V.; Lema, C.; Varela-Ramirez, A.; Gilbert, I. H.; Almeida, I. C.; Maldonado, R. A. PLoS Negl Trop Dis. 2016, 10, e0004540.

 

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