Papers 2010

Acetazolamide-based fungal chitinase inhibitors. Schuettelkopf, A.; Gros, L.; Blair, D. E.; Frearson, J. A.; van Aalten, D. M. F.; Gilbert, I. H. Bioorg. Med. Chem. 2010, 18, 8334-8340.   pubmed  journal

Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum. Cui, H.; Ruiz-Perez, L. M.; Gonzalez-Pacanowska, D.; Gilbert, I. H. Bioorg. Med. Chem., 2010, 18, 7302-7309.   pubmed  journal

Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase. Cui, H.; Ruda, G.-F.; Carrero-Lerida, J.; Ruiz-Perez, L. M.; Gilbert, I. H.; Gonzalez-Pacanowska, D. Eur. J. Med. Chem. 2010, 45, 5140-5149.   pubmed  journal

Design and Preparation of Sterol Mimetics as Potential Antiparasitics. Gigante, F.; Kaiser, M.; Brun, R.; Gilbert, I. H. Bioorg. Med. Chem. 2010, 18, 7291-7301.   pubmed  journal

Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds. Ruda, G.-F.; Wong, P. E.; Alibu, V. P.; Norval, S.; Read, K. D.; Barrett, M. P.; Gilbert, I. H. J. Med. Chem.; 2010, 53, 6071-6078.   pubmed  journal

Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif. Klee, N.; Wong, P. E.; Baragana, B.; El Mazouni, F.; Phillips, M. A.; Barrett, M. P.; Gilbert, I. H. Bioorg. Med. Chem., 2010, 20, 4364-4366.   pubmed  journal

Virtual Fragment Screening for Novel Inhibitors of 6-Phosphogluconate Dehydrogenase. Ruda, G. F.; Campbell, G.; Alibu, V. P.; Barrett, M. P.; Brenk, R.; Gilbert, I. H. Bioorg. Med. Chem., 2010, 18, 5056-5062.   pubmed  journal

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Frearson, J. A.; Brand, S.; McElroy, S. P.; Cleghorn, L. A. T.; Smid, O.; Stojanovski, L.; Price, H. P.; Guther, M. L. S.; Torrie, L. S.; Robinson, D. A.; Hallyburton, I.; Mpamhanga, C. P.; Brannigan, J. A.; Wilkinson, A. J.; Hodgkinson, M.; Hui, R.; Qiu, W.; Raimi, O. G.; Van Aalten, D. M. F.; Brenk, R.; Gilbert, I. H.; Read, K. D.; Fairlamb, A. H.; Ferguson, M. A. J.; Smith, D. F.; Wyatt, P. G. Nature, 2010, 464, 728-732.   pubmed  journal

Structural basis for the efficient phosphorylation of AZTMP and dGMP by Plasmodium falciparum type I thymidylate kinase. Whittingham, J.; Carrero-Lerida, J.; Brannigan, J. A.; Ruiz-Perez, L. M.; Silva, A. P. G.; Fogg, M. J.; Wilkinson, A. J.; Gilbert, I. H.; Wilson, K. S.; Gonzalez-Pacanowska, D. Biochem. J., 2010, 428, 499-509.   pubmed  journal

Water-soluble polymer–drug conjugates for combination chemotherapy against visceral leishmaniasis. Nicoletti, S.; Seifert, K.; Gilbert, I. H. Bioorg. Med. Chem., 2010, 18, 2559–2565.   pubmed  journal