Papers 2009

Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei. Spinks, D.; Shanks, E. J.; Cleghorn, L. A. T.; McElroy, S.; Jones, D.; James, D.; Fairlamb, A. H.; Frearson, J. A.; Wyatt, P. G.; Gilbert, I. H. ChemMedChem, 2009, 4, 2060-2069.link to journal abstract in pubmed link to the journal where paper was published

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis. Torrie, L. S.; Wyllie, S.; Spinks, D.; Oza, S. L.; Thompson, S.; Harrison, J. R.; Gilbert, I. H.; Wyatt, P. G.; Fairlamb, A. H.; Frearson, J. A. J. Biol. Chem., 2009, 52, 36137-36145.link to journal abstract in pubmed link to the journal where paper was published

Thiolactomycin analogues as potential anti-Toxoplasma gondii agent. Martins-Duarte, E. S.; Jones, S. M.; Gilbert, I. H.; Atella, G. C.; de Souza, W.; Vommaro, R. C. Parasitol. Int., 2009, 58, 411-415.link to journal abstract in pubmed link to the journal where paper was published

SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents. Gigante, F.; Kaiser, M.; Brun, R.; Gilbert, I. H. Bioorg. Med. Chem., 2009, 17, 5950-5961.link to journal abstract in pubmed link to the journal where paper was published

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase. Patterson, S.; Jones, D. C.; Shanks, E. J.; Frearson, J. A.; Gilbert, I. H.; Wyatt, P. G.; Fairlamb, A. H.. ChemMedChem, 2009, 4, 1341-1353.link to journal abstract in pubmed link to the journal where paper was published

One Scaffold, Three Binding Modes. Mpamhanga, C. P.; Spinks, D.; Tulloch, L. B.; Shanks, E.; Robinson, D.; Collie, I.; Fairlamb, A. H.; Wyatt, P. G.; Frearson, J. A.; Hunter, W. N.; Gilbert, I. H.; Brenk, R. J. Med. Chem., 2009, 52, 4454-4465.link to journal abstract in pubmed link to the journal where paper was published

Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis. Richardson, J. L.; Nett, I. R. E.; Jones, D. C.; Abdille, M. H.; Gilbert, I. H.; Fairlamb, A. H. ChemMedChem, 2009, 4, 1333-1340.link to journal abstract in pubmed link to the journal where paper was published

Targeted delivery of compounds to Trypanosoma brucei using the melamine motif. Chollet, C.; Baliani, A.; Wong, P. E.; Barrett, M. P.; Gilbert, I. H. Bioorg. Med. Chem., 2009, 17, 2512-2523.link to journal abstract in pubmed link to the journal where paper was published

Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites. Baliani, A.; Peal, V.; Gros, L.; Brun, R.; Kaiser, M.; Barrett, M. P.; Gilbert, I. H. Org. Biomol. Chem., 2009, 7, 1154-1166.link to journal abstract in pubmed link to the journal where paper was published

N-(2-hydroxypropyl)methacrylamide (HPMA) – amphotericin B copolymer conjugates as anti-leishmanial agents. Nicoletti, S.; Seifert, K.; Gilbert, I. H. Int. J. Antimicrob. Agents, 2009, 33, 441-448.link to journal abstract in pubmed link to the journal where paper was published

Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase. McCarthy, O.; Musso-Buendia, A.; Kaiser, M.; Brun, R.; Ruiz-Perez, L. M.; Johansson, N. G.; Pacanowska, D. G.; Gilbert, I. H. Eur. J. Med. Chem., 2009, 44, 678-688.link to journal abstract in pubmed link to the journal where paper was published

Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni. Musso-Buendia, J. A.; Vidal, A.E., Kasinthan, G.; Nguyen, C.; Carrero-Lerida, J.; Ruiz-Perez, L. M.; Wilson, K.; Johansson, N. G.; Gilbert, I. H.; Gonzalez-Pacanowska, D. J. Enzyme Inhib. Med. Chem., 2009, 24, 111-116.link to journal abstract in pubmed link to the journal where paper was published

 

Top