Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei. Spinks, D.; Shanks, E. J.; Cleghorn, L. A. T.; McElroy, S.; Jones, D.; James, D.; Fairlamb, A. H.; Frearson, J. A.; Wyatt, P. G.; Gilbert, I. H. ChemMedChem, 2009, 4, 2060-2069.
Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis. Torrie, L. S.; Wyllie, S.; Spinks, D.; Oza, S. L.; Thompson, S.; Harrison, J. R.; Gilbert, I. H.; Wyatt, P. G.; Fairlamb, A. H.; Frearson, J. A. J. Biol. Chem., 2009, 52, 36137-36145.
Thiolactomycin analogues as potential anti-Toxoplasma gondii agent. Martins-Duarte, E. S.; Jones, S. M.; Gilbert, I. H.; Atella, G. C.; de Souza, W.; Vommaro, R. C. Parasitol. Int., 2009, 58, 411-415.
SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents. Gigante, F.; Kaiser, M.; Brun, R.; Gilbert, I. H. Bioorg. Med. Chem., 2009, 17, 5950-5961.
Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase. Patterson, S.; Jones, D. C.; Shanks, E. J.; Frearson, J. A.; Gilbert, I. H.; Wyatt, P. G.; Fairlamb, A. H.. ChemMedChem, 2009, 4, 1341-1353.
One Scaffold, Three Binding Modes. Mpamhanga, C. P.; Spinks, D.; Tulloch, L. B.; Shanks, E.; Robinson, D.; Collie, I.; Fairlamb, A. H.; Wyatt, P. G.; Frearson, J. A.; Hunter, W. N.; Gilbert, I. H.; Brenk, R. J. Med. Chem., 2009, 52, 4454-4465.
Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis. Richardson, J. L.; Nett, I. R. E.; Jones, D. C.; Abdille, M. H.; Gilbert, I. H.; Fairlamb, A. H. ChemMedChem, 2009, 4, 1333-1340.
Targeted delivery of compounds to Trypanosoma brucei using the melamine motif. Chollet, C.; Baliani, A.; Wong, P. E.; Barrett, M. P.; Gilbert, I. H. Bioorg. Med. Chem., 2009, 17, 2512-2523.
Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites. Baliani, A.; Peal, V.; Gros, L.; Brun, R.; Kaiser, M.; Barrett, M. P.; Gilbert, I. H. Org. Biomol. Chem., 2009, 7, 1154-1166.
N-(2-hydroxypropyl)methacrylamide (HPMA) – amphotericin B copolymer conjugates as anti-leishmanial agents. Nicoletti, S.; Seifert, K.; Gilbert, I. H. Int. J. Antimicrob. Agents, 2009, 33, 441-448.
Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase. McCarthy, O.; Musso-Buendia, A.; Kaiser, M.; Brun, R.; Ruiz-Perez, L. M.; Johansson, N. G.; Pacanowska, D. G.; Gilbert, I. H. Eur. J. Med. Chem., 2009, 44, 678-688.
Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni. Musso-Buendia, J. A.; Vidal, A.E., Kasinthan, G.; Nguyen, C.; Carrero-Lerida, J.; Ruiz-Perez, L. M.; Wilson, K.; Johansson, N. G.; Gilbert, I. H.; Gonzalez-Pacanowska, D. J. Enzyme Inhib. Med. Chem., 2009, 24, 111-116.