First Annual CeTPD Christmas Retreat
The group held their 1st Annual CeTPD Christmas Retreat on the 25th of November at Piperdam Leisure Resort. The evening was not only a party but also a chance to take stock of how far we’ve come this last year,…
Category 2021
Three heads are better than two in drug discovery concept
LTDD 2021 LinkedIn lead ben post graphic, featuring A best in class method to quantify target engagement and cellular entry for PROTACs, presented by James Vasta Researchers from the University of Dundee and Promega Corporation have shown how a “three-headed…
Tag tech provides insight into undruggable diseases
Scientists at the University of Dundee have developed a new technology that provides a greater understanding into the biology of ‘undruggable’ diseases. Cells are composed of thousands of interacting proteins and their malfunction is a primary mechanism of disease development.…
Our new paper in Nature Chemical Biology reports trivalent PROTACs as a strategy to boost targeted protein degraders mechanism of action
Great collaboration with Danette Daniels’s group at Promega! Read the Open Access full article. Read the UoD News article: “Three heads are better than two in drug discovery concept“ Authors: Satomi Imaide, Kristin M. Riching, Nikolai Makukhin, Vesna Vetma, Claire Whitworth, Scott J.…
Marie Sklodowka-Curie Individual Fellowships awarded
Congratulations to Angus and Claudia for being awarded Marie Sklodowka-Curie Individual Fellowships! These prestigious Fellowships will enable Angus and Claudia to take forward their postdoctoral research and projects in the group.
New paper: Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity
Great work by Adam and Conner in this work collaboration with Scott Lokey’s Lab! Read the Open Access full article. Authors: Victoria G. Klein, Adam G. Bond, Conner Craigon, R. Scott Lokey*, and Alessio Ciulli* Title: Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability…
Lab contributing to Dundee being ranked top 6 in UK for spinout success
The University of Dundee is one of the best universities in the UK for producing successful spinouts, according to a new report. Read full press release on the University of Dundee website. Related links UoD PR: Dundee ranked top 6…
Beginner’s guide to PROTACs and targeted protein degradation published
Our beginner’s guide to PROTACs and targeted protein degradation is now out in The Biochemist. Read the full article open access. Authors: Alessio Ciulli* and Nicole Trainor Title: A beginner’s guide to PROTACs and targeted protein degradation Summary PROTACs are…
Successful anti-cancer alliance extended
The expansion of an exemplary industry-academia collaboration will see the University of Dundee, in partnership with Boehringer Ingelheim, intensify its efforts to develop new medicines that target and destroy key cancer-causing proteins, which have previously been regarded as undruggable. Dundee…
Estimating the cooperativity of PROTAC
New preprint: Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay Great work by Gugi. Read the pre-print article Authors: Guilherme Castro, Alessio Ciulli* Title: Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay Abstract Cooperativity…