Category: News
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Our new paper describing stereoselective syntheses of allele-selective BET inhibitors bumped-JQ1 is now out in the RSC journal Org. Biomol. Chem. Congratulations to Adam and Andrea, on their development of this new route to synthesise the…
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Our review on probing epigenetic reader domains with chemical biology is now published in Current Opinion in Chemical Biologyfor website. Congratulations to Alessandra Cipriano, well done! Alessandra was a visiting PhD student with us, from Gianluca Sbardella’s group…
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Our collaborative work on PROTAC structure-permeability relationships is now published in ACS Med Chem Lett. Title: Understanding and Improving the Membrane Permeability of VH032-Based PROTACs Authors: Victoria G. Klein, Chad E. Townsend, Andrea Testa, Michael Zengerle,…
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Claire and Alessio’s News & Views story on Carolyn Bertozzi’s group work on LYTACs is now published in Nature Title: Protein degraders extend their reach Authors: Claire Whitworth, Alessio Ciulli Molecules have previously been made that…
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Our collaboration with the Sapkota and Ganley Labs is now published in Cell Chemical Biology. Highlights Ligand (L)-inducible AdPROM consists of Halo conjugated to a target protein binder Target protein is degraded with HaloPROTAC in cells…
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Completion of our University of Dundee spin-off new-co Amphista therapeutics’s Series A investment announced today. Great news and congratulations to the whole team for this achievement! Read more on Twitter Related links University of Dundee Press Release:…
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Read the University of Dundee’s feature story: Collaboration with Boehringer Ingelheim: A world-changing idea: the development a completely new class of drugs with the potential to “drug the undruggable”
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Our dual Brd7/9 PROTAC degrader VZ185 is now available for free on Boehringer Ingelheim portal OpnMe.com Go on OpnMe.com to order VZ185 for free, and start your research now! Related links OpnMe entry: BRD7/BRD9 PROTAC | VZ185 University…
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Check our latest paper published in Angewandte. Closing the circle: A macrocyclic PROTAC has been designed and synthesized by adding a cyclizing linker to MZ1, a PROTAC targeting the bromodomain of the BET protein, Brd4. A…
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School of Life Science’s Professor Alessio Ciulli was amongst a selected group of world’s leading expert scientists and key opinion leaders who spoke at the Galien Forum on October 24, 2019, at the Alexandria Center in…