Our new paper describing stereoselective syntheses of allele-selective BET inhibitors bumped-JQ1 is now out in the RSC journal Org. Biomol. Chem. Congratulations to Adam and Andrea, on their development of this new route to synthesise the compounds! Read the Open…
Our review on probing epigenetic reader domains with chemical biology is now published in Current Opinion in Chemical Biologyfor website. Congratulations to Alessandra Cipriano, well done! Alessandra was a visiting PhD student with us, from Gianluca Sbardella’s group at the University of…
Our collaborative work on PROTAC structure-permeability relationships is now published in ACS Med Chem Lett. Title: Understanding and Improving the Membrane Permeability of VH032-Based PROTACs Authors: Victoria G. Klein, Chad E. Townsend, Andrea Testa, Michael Zengerle, Chiara Maniaci, Scott J.…
Claire and Alessio’s News & Views story on Carolyn Bertozzi’s group work on LYTACs is now published in Nature Title: Protein degraders extend their reach Authors: Claire Whitworth, Alessio Ciulli Molecules have previously been made that induce protein destruction inside…
Our collaboration with the Sapkota and Ganley Labs is now published in Cell Chemical Biology. Highlights Ligand (L)-inducible AdPROM consists of Halo conjugated to a target protein binder Target protein is degraded with HaloPROTAC in cells expressing L-AdPROM construct HaloPROTAC-mediated…
Completion of our University of Dundee spin-off new-co Amphista therapeutics’s Series A investment announced today. Great news and congratulations to the whole team for this achievement! Read more on Twitter Related links University of Dundee Press Release: Funding success for University…
Read the University of Dundee’s feature story: Collaboration with Boehringer Ingelheim: A world-changing idea: the development a completely new class of drugs with the potential to “drug the undruggable”
Our dual Brd7/9 PROTAC degrader VZ185 is now available for free on Boehringer Ingelheim portal OpnMe.com Go on OpnMe.com to order VZ185 for free, and start your research now! Related links OpnMe entry: BRD7/BRD9 PROTAC | VZ185 University of Dundee and Boehringer…
Check our latest paper published in Angewandte. Closing the circle: A macrocyclic PROTAC has been designed and synthesized by adding a cyclizing linker to MZ1, a PROTAC targeting the bromodomain of the BET protein, Brd4. A co‐crystal structure of macroPROTAC‐1…
School of Life Science’s Professor Alessio Ciulli was amongst a selected group of world’s leading expert scientists and key opinion leaders who spoke at the Galien Forum on October 24, 2019, at the Alexandria Center in New York City. Alessio’s…