Our review on structure, protein-protein interactions and drug discovery targeting Cullin RING E3 Ubiquitin Ligases is now published in the Biochemical Journal. You can read our paper Open Access.
Our paper on structural basis of histone tail recognition by human BAZ2A (TIP5) and BAZ2B epigenetic reader domains PHD finger and bromodomain now published in Structure. Read our Open Access full-text article
Alessio Ciulli has won a 2014 Talented Young Italians Prize, awarded by the Italian Chamber of Commerce and Industry for the UK. Eight awards were conferred in four categories, with Alessio receiving the award for the “Research and Innovation” category,…
The Group Christmas dinner is held at the Lands of Loyal, Alyth
Our paper on biophysical investigation of interactions and assembly of full-size SOCS2:EloBC:Cul5:Rbx2 E3 ubiquitin ligase is now published in J. Biol. Chem. Read our Just In Press article.
Just published in Science! Our paper describing a chemical genetics bump-and-hole approach to engineer controlled selectivity of BET bromodomain inhibitors. Read our paper open-access in Europe PMC Highlighted in the BBSRC website Highlighted in Cancer Discovery Research Watch. Highlighted in Nature Chemical Biology Highlighted…
Carles Galdeano wins the Best Poster Prize at the 2014 EFMC-ISMC conference in Lisbon. Alessio Bortoluzzi speaks at the EMBO Workshop “Advances in protein–protein interaction analysis and modulation” in Hyeres, France.
Our paper elucidating binding hotspots of the BAZ2B bromodomain:histone interaction now published in Biochemistry. Read our paper on ACS publication website.
Our paper on structure-guided optimization of nanomolar inhibitors of the VHL-HIFalpha protein-protein interaction is now published in J. Med. Chem. Read our paper on ACS Publications website.
Our review on NMR approaches in structure-based lead discovery for targeting multi-protein complexes is now published in Prog. Biophys. Mol. Biol. You can read our paper open-access .