New paper: Structure-guided design of peptides
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Category News
Relationships leading to the potent VHL inhibitor VH298
The article will be part of the journal Special Issue on “Inducing Protein Degradation as a New Therapeutic Strategy”, edited by Prof. Craig Crews and Prof. Shameng Wang. Read our article Open Access
VHL inhibitor VH298 as novel chemical probe of the hypoxia signalling pathway
Our paper characterising VHL inhibitor VH298 as novel chemical probe of the hypoxia signalling pathway is now published in Nature Communications. Read our open access article. Featured in the UoD News websites Access VH298 from the Chemical Probes portal. Related Links
Promotions for academic staff
Congratulations to Alessio for being promoted to Professor (Chair) from 1st October 2016. Alessio Ciulli, Vicki Cowling, Sonia Rocha, Helen Walden and Sarah Coulthurst were all successful in being promoted during this year’s round of Academic Staff Review for the…
Target validation: Switching domains
Alessio’s News & Views article titled “Target validation: Switching domains” is now published in Nat Chem Biol. Read the news and views article. Read the “Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inihibition” by Hohmann et al.
Fellow of the Royal Society of Chemistry (FRSC)
Alessio has been admitted as a Fellow of the Royal Society of Chemistry (FRSC). Dr Alessio Ciulli, from the Division of Biological Chemistry and Drug Discovery, in the School of Life Sciences at the University of Dundee is now a…
Boehringer Ingelheim and University of Dundee collaborate to develop new class of medicines
Collaboration aims to develop PROteolysis TArgeting Chimeric molecules (PROTACs) – a new therapeutic modality that is able to degrade proteins playing a central role in disease processes PROTACs and their new mechanism of action are expected to open new horizons…
Advanced chemical genetics for epigenetics
Our review on advanced chemical genetics for epigenetics is now published in Current Opinion in Chemical Biology! Well done Andrew, Kwok-Ho and Michael! Read our review open access. Review synopsis In conventional chemical genetics, cell-active small-molecules directly block protein activity,…
Alessio Ciulli winner MedChemComm award
Alessio Ciulli is designated as the winner of the 2016 MedChemComm Emerging Investigator Lectureship. Learn more about the MedChemComm award. Alessio delivered his Prize lecture at the European Federation of Medicinal Chemistry International Symposium on Medicinal Chemistry (EFMC-ISMC) held in…
Selectivity of chemical probes targeting bromodomains
Our review on selectivity of chemical probes targeting bromodomains is now published in Future Medicinal Chemistry. Read our open access review without restriction .