Great work by Adam and Conner in this work collaboration with Scott Lokey’s Lab! Read the Open Access full article. Authors: Victoria G. Klein, Adam G. Bond, Conner Craigon, R. Scott Lokey*, and Alessio Ciulli* Title: Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability…
The University of Dundee is one of the best universities in the UK for producing successful spinouts, according to a new report. Read full press release on the University of Dundee website. Related links UoD PR: Dundee ranked top 6…
Our beginner’s guide to PROTACs and targeted protein degradation is now out in The Biochemist. Read the full article open access. Authors: Alessio Ciulli* and Nicole Trainor Title: A beginner’s guide to PROTACs and targeted protein degradation Summary PROTACs are…
The expansion of an exemplary industry-academia collaboration will see the University of Dundee, in partnership with Boehringer Ingelheim, intensify its efforts to develop new medicines that target and destroy key cancer-causing proteins, which have previously been regarded as undruggable. Dundee…
New preprint: Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay Great work by Gugi. Read the pre-print article Authors: Guilherme Castro, Alessio Ciulli* Title: Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay Abstract Cooperativity…
Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity. Great work by Adam, Conner, and Tori Klein from Scott Lokey’s lab. Read the pre-print article. Authors: Klein, V.G., Bond, A.G, Craigon, C., Lokey, R.S., Ciulli, A.* Title:…
A new translational research centre will bolster the University of Dundee’s world-leading position in a field that is revolutionising drug discovery, while helping to facilitate the development of high growth companies and create skilled jobs. A new translational research centre…
New pre-print: VHL inhibitor binding increases intracellular level of VHL Great work by Julianty, in collaboration with Sonia Rocha Read the pre-print article Authors: Julianty Frost, Sonia Rocha*, Alessio Ciulli* Title: VHL inhibitor binding increases intracellular level of VHL Abstract The von…
Will and Manfred’s review on the present and future of PROTACs for cancer therapy is now out in Current Opinion in Pharmacology Read the full article. Authors: William Farnaby*, Manfred Koegl*, Darryl B. McConnell, Alessio Ciulli Title: Transforming targeted cancer…
Amphista Therapeutics, a University of Dundee spinout company, has announced a near-£40 million investment that will further its work to develop new drugs for a range of diseases. Amphista is a biopharmaceutical company creating first-in-class therapeutics that harness the body’s…