Read the article Open Access as SharedIt version Fantastic job Will, Manfred and team! Researchers can now access the SMARCA2/4 degrader ACBI1 for their own research – order the molecule completely free of charge from OpnMe. Related Links UoD PR: Boehringer…
Measuring kinetics by surface plasmon resonance (SPR), we reveal how striking differences in stability and lifetime of target:PROTAC:ligase ternary complexes influence initial rates of PROTAC induced protein degradation. Congratulations to Michael, Scott, Claire, Will and our colleagues at Boehringer Ingelheim. Read…
Read the open access article Congratulations to Hannah Tovell in Dario Alessi’s group for the excellent job on this study. Well done Andrea and Chiara for the chemistry contributions to the project!
In an article in the journal Nature, Megan Scudellari reflects on the short history of PROTACs – a new type of drug design that is galvanising the Pharmaceutical industry, with the first PROTAC drug from Arvinas about to enter phase-1 clinical…
Our new PROTAC paper on hijacking E3 ligases against each others is now published in Bioorg. Med. Chem. Read the full paper Open Access. Well done Miriam, Chiara, Scott and Andrea on this work!
Our latest paper describing novel fluorinated VHL ligands as spy molecules for 19F NMR screening is out in Chemical Communications. Well done to Guilherme and congrats on his first first-author article!
Our SAR story disclosing dual Brd7/9 PROTAC degrader VZ185 is published in J. Med. Chem. Congratulations to Vittoria, Scott, Chiara and Andrea, and all our collaborators for their contributions to this work! Related Links Promega Connections blog: “A Roadmap for PROTAC Development”
The Lab Christmas Dinner was held at Lands of Loyal, Alyth. It was a productive and fun Year, Merry Christmas everyone! Merry Christmas to everyone! It has been a very productive, intense and fun year. Thank You all and congratulations…
Alessio delivers a Chemistry World webinar titled “Targeted protein degradation using small molecules” You can view Alessio’s PROTAC webinar on Chemistry World website.
Two ligandable pockets on the surface of the VHL E3 ligase are revealed in our new paper just out in J Med Chem Well done to Xavi and Inge! Read our paper Open Access.