Two ligandable pockets on the surface of the VHL E3 ligase
Two ligandable pockets on the surface of the VHL E3 ligase are revealed in our new paper just out in J Med Chem Well done to Xavi and Inge! Read our paper Open Access.
Category News
Introducing 3-Fluoro-4-hydroxyprolines
Introducing 3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by VHL E3 ligase for protein degradation. Very proud of Lab’s work just out in @JACS by Andrea, Xavi and coworkers! well done everyone at @UoDLifeSciences and beyond, and thanks to @ERC_Research @MSCActions for funding Read our article…
Molecular recognition of helical histone tail by PHD finger domains
Our paper on the molecular recognition of helical histone tail by PHD finger domains is now published in Biochemical Journal. Well done to Alessio B., Anastasia, Xavi – and Manuel! Read the full paper open access.
First ternary crystal structure of a PROTAC bound to to its E3 ligase VHL and Brd4 target
Our paper reporting the first ternary crystal structure of a PROTAC bound to to its E3 ligase VHL and Brd4 target is now published in Nature Chemical Biology! Our work provides unprecedented insights into how PROTACs work. Congratulations to Morgan, Andrea, Xavi and Kwok-Ho for a…
Recognition and small-molecule mimicry of degrons by E3 ligases
Our review on recognition and small-molecule mimicry of degrons by E3 ligases is now published in Current Opinion in Structural Biology. Well done Xavi! Read our review. Highlights: Abstract The ubiquitin–proteasome system is a master regulator of protein homeostasis, by…
Thioamide substitution to probe the hydroxyproline recognition of VHL ligands
The article is a contribution to the journal’s Special Issue for the 2018 Tetrahedron Young Investigators Award for Matthew Fuchter. Read our article Open Access Congratulations Pedro and Xavi, well done! The article is a contribution to the journal’s Special…
Ligandability of PHD finger domains of BAZ2A and BAZ2B
Read our Open Access article Congratulations to Anastasia, Xavi and colleagues! Read our Open Access article Congratulations to Anastasia, Xavi and colleagues!
Molecular recognition of ternary complexes for targeted protein degradation
Read our review Read our review
First crystal structure of the VHL-EloBC-Cul2-Rbx1 multi-subunit complex
Read our article open access
Our paper studying the effect of linking on the mechanism of action of BET degraders
Read our paper open access here. The article will be published as part of the a Special Issue on “Inducing Protein Degradation as a Therapeutic Strategy“.