A one day symposium for the Scottish cryo-EM community took place on 30 November 2023 The First Scottish cryo-EM symposium attracted over 90 participants from across academia and industry. The event provided the opportunity to hear updates from the rapidly growing community…
On Thursday 23rd November Alessio joined David McBeth, VP for Entreprise and Economic Transformation at Dundee, and colleagues from the University’s RIS and Amphista therapeutics in Leeds city centre for the 2023 PraxisAuril KE awards ceremony. The PraxisAuril KE Awards…
‘Trojan Horse’ chemical tool allows researchers to target ‘undruggable’ proteins University of Dundee researchers have developed a new molecule that is able to target and bind to a protein class previously considered undruggable by using a masking technique to enter…
The University of Dundee has today (Oct 26, 2023) celebrated the official opening of its multi-million pound Centre for Targeted Protein Degradation (CeTPD), by UK Science Minister George Freeman who met researchers behind pioneering studies of potential ways to treat…
The Ciulli Laboratory develops novel small molecules inducing targeted protein degradation and modulating protein-protein interactions. We do research on fundamental chemical biology and translate it via collaboration partnership with the biopharma industry and by creation of spin-out companies. Pioneering discoveries…
We are excited to share our latest publication on the development of the first SOCS2 inhibitors | Just out in Nature Communications Our lab has worked relentlessly over many many years to develop phosphotyrosine-based covalent ligands of the E3 ligase SOCS2…
The 17th EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders Graphical Abstract The 17th EFMC Short Course on Medicinal Chemistry this year focused on Small Molecule Protein Degraders, and the opportunities and challenges that they present as a novel…
Alessio was giving one of the plenary lectures at the IMPRS-LM Student Symposium
We are happy to share our new publication on the structure-guided improvement of our von Hippel–Lindau (VHL) inhibitors | Just out ASAP in the Journal of Medicinal Chemistry We design a new di-Methyl analogue of VH101 (cmpnd 30) and qualify it as…
The University of Dundee has been named the UK’s best for supporting spinout businesses, according to industry-leading analysis. The University of Dundee has been named the UK’s best for supporting spinout businesses, according to industry-leading analysis by Octopus Ventures. Companies…