Category: 2018
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Our SAR story disclosing dual Brd7/9 PROTAC degrader VZ185 is published in J. Med. Chem. Congratulations to Vittoria, Scott, Chiara and Andrea, and all our collaborators for their contributions to this work! Related Links Promega Connections blog: “A Roadmap for PROTAC…
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The Lab Christmas Dinner was held at Lands of Loyal, Alyth. It was a productive and fun Year, Merry Christmas everyone! Merry Christmas to everyone! It has been a very productive, intense and fun year. Thank…
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Alessio deliver a Chemistry World webinar titled “Targeted protein degradation using small molecules” You can view Alessio’s PROTAC webinar on Chemistry World website.
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Two ligandable pockets on the surface of the VHL E3 ligase are revealed in our new paper just out in J Med Chem Fragment screening and Xray crystallographic soaking identified two novel pockets – one on…
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Introducing 3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by VHL E3 ligase for protein degradation. @EndriuT developed diverse synthetic routes to achieve all four diastereoisomers of unprecedented unnatural fluorinated analogues of 4-hydroxyproline (Hyp) – the most…