Our SAR story disclosing dual Brd7/9 PROTAC degrader VZ185 is published in J. Med. Chem. Congratulations to Vittoria, Scott, Chiara and Andrea, and all our collaborators for their contributions to this work! Related Links Promega Connections blog: “A Roadmap for PROTAC Development”
The Lab Christmas Dinner was held at Lands of Loyal, Alyth. It was a productive and fun Year, Merry Christmas everyone! Merry Christmas to everyone! It has been a very productive, intense and fun year. Thank You all and congratulations…
Alessio delivers a Chemistry World webinar titled “Targeted protein degradation using small molecules” You can view Alessio’s PROTAC webinar on Chemistry World website.
Two ligandable pockets on the surface of the VHL E3 ligase are revealed in our new paper just out in J Med Chem Well done to Xavi and Inge! Read our paper Open Access.
Introducing 3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by VHL E3 ligase for protein degradation. Very proud of Lab’s work just out in @JACS by Andrea, Xavi and coworkers! well done everyone at @UoDLifeSciences and beyond, and thanks to @ERC_Research @MSCActions for funding Read our article…