Category: 2017
1 min read
Well done for this tour-de-force study to our BBSRC EastBio PhD student Andrew, to Kwok-Ho, Andrea, and to former Lab members Michael, Lars and Matt -with important contributions from our collaborators too! Gallery Thumbnail - ToC Graphics…
1 min read
Our paper on the molecular recognition of helical histone tail by PHD finger domains is now published in Biochemical Journal. Well done to Alessio B., Anastasia, Xavi – and Manuel! Read the full paper open access.
1 min read
Our paper reporting the first ternary crystal structure of a PROTAC bound to to its E3 ligase VHL and Brd4 target is now published in Nature Chemical Biology! Our work provides unprecedented insights into how PROTACs…
1 min read
Our review on recognition and small-molecule mimicry of degrons by E3 ligases is now published in Current Opinion in Structural Biology. Well done Xavi! Read our review. Highlights: E3 ligases recruit substrates for proteasomal degradation by…
1 min read
The article is a contribution to the journal’s Special Issue for the 2018 Tetrahedron Young Investigators Award for Matthew Fuchter. Read our article Open Access Congratulations Pedro and Xavi, well done! Gallery Thumbnail - Graphical abstract…
1 min read
Read our Open Access article Congratulations to Anastasia, Xavi and colleagues! Gallery Thumbnail - Table of Graphics Gallery Thumbnail - Figure 1. Druggable pockets on BAZ2A/B PHD and validated fragments Gallery Thumbnail - Figure 2. Biophysical…
1 min read
Read our review Gallery Thumbnail - Journal special issue: the cover Gallery Thumbnail - Figure 1. Comparison of binary and ternary therapeutic approaches Gallery Thumbnail - Figure 2. Molecular glues Gallery Thumbnail - Figure 3. Proteolysis-targeting…
1 min read
Read our article open access Gallery Thumbnail - Graphical Abstract Gallery Thumbnail - Figure 1. Crystal Structure of the CRL2VHL Complex Gallery Thumbnail - Figure 2. The CRL2VHL Complex Is Dynamic and Flexible Gallery Thumbnail -…
1 min read
Read our paper open access here. The article will be published as part of the a Special Issue on “Inducing Protein Degradation as a Therapeutic Strategy“. Gallery Thumbnail - ToC Graphics Gallery Thumbnail - Chart 1. Chemical Structures…
1 min read
Read our full paper open access Gallery Thumbnail - ToC: Cul2-based peptides Gallery Thumbnail - Figure 1. A) N-terminal tail in the Cullin family. B) The CRL2VHL complex Gallery Thumbnail - Figure 2 – Biolayer interferometry…