Author: UoD Web Team
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Introducing 3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by VHL E3 ligase for protein degradation. @EndriuT developed diverse synthetic routes to achieve all four diastereoisomers of unprecedented unnatural fluorinated analogues of 4-hydroxyproline (Hyp) – the most…
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Our paper on the molecular recognition of helical histone tail by PHD finger domains is now published in Biochemical Journal. Well done to Alessio B., Anastasia, Xavi – and Manuel! Read the full paper open access.
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Our paper reporting the first ternary crystal structure of a PROTAC bound to to its E3 ligase VHL and Brd4 target is now published in Nature Chemical Biology! Our work provides unprecedented insights into how PROTACs…
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Our review on recognition and small-molecule mimicry of degrons by E3 ligases is now published in Current Opinion in Structural Biology. Well done Xavi! Read our review. Highlights: E3 ligases recruit substrates for proteasomal degradation by…
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The article is a contribution to the journal’s Special Issue for the 2018 Tetrahedron Young Investigators Award for Matthew Fuchter. Read our article Open Access Congratulations Pedro and Xavi, well done! Gallery Thumbnail - Graphical abstract…
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Read our Open Access article Congratulations to Anastasia, Xavi and colleagues! Gallery Thumbnail - Table of Graphics Gallery Thumbnail - Figure 1. Druggable pockets on BAZ2A/B PHD and validated fragments Gallery Thumbnail - Figure 2. Biophysical…
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Read our review Gallery Thumbnail - Journal special issue: the cover Gallery Thumbnail - Figure 1. Comparison of binary and ternary therapeutic approaches Gallery Thumbnail - Figure 2. Molecular glues Gallery Thumbnail - Figure 3. Proteolysis-targeting…
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Read our article open access Gallery Thumbnail - Graphical Abstract Gallery Thumbnail - Figure 1. Crystal Structure of the CRL2VHL Complex Gallery Thumbnail - Figure 2. The CRL2VHL Complex Is Dynamic and Flexible Gallery Thumbnail -…
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Read our paper open access here. The article will be published as part of the a Special Issue on “Inducing Protein Degradation as a Therapeutic Strategy“. Gallery Thumbnail - ToC Graphics Gallery Thumbnail - Chart 1. Chemical Structures…
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Read our full paper open access Gallery Thumbnail - ToC: Cul2-based peptides Gallery Thumbnail - Figure 1. A) N-terminal tail in the Cullin family. B) The CRL2VHL complex Gallery Thumbnail - Figure 2 – Biolayer interferometry…