Author: UoD Web Team
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Our paper on the molecular recognition of helical histone tail by PHD finger domains is now published in Biochemical Journal. Well done to Alessio B., Anastasia, Xavi – and Manuel! Read the full paper open access.
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Our paper reporting the first ternary crystal structure of a PROTAC bound to to its E3 ligase VHL and Brd4 target is now published in Nature Chemical Biology! Our work provides unprecedented insights into how PROTACs…
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Our review on recognition and small-molecule mimicry of degrons by E3 ligases is now published in Current Opinion in Structural Biology. Well done Xavi! Read our review. Highlights: E3 ligases recruit substrates for proteasomal degradation by…
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Our paper characterising VHL inhibitor VH298 as novel chemical probe of the hypoxia signalling pathway is now published in Nature Communications. Read our open access article. Access VH298 from the Chemical Probes portal. Related Links Article…
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Congratulations to Alessio for being promoted to Professor (Chair) from 1st October 2016. Alessio Ciulli, Vicki Cowling, Sonia Rocha, Helen Walden and Sarah Coulthurst were all successful in being promoted during this year’s round of Academic…
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Alessio’s News & Views article titled “Target validation: Switching domains” is now published in Nat Chem Biol. Read the news and views article. Read the “Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inihibition”…
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Alessio has been admitted as a Fellow of the Royal Society of Chemistry (FRSC). Dr Alessio Ciulli, from the Division of Biological Chemistry and Drug Discovery, in the School of Life Sciences at the University of…
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Collaboration aims to develop PROteolysis TArgeting Chimeric molecules (PROTACs) – a new therapeutic modality that is able to degrade proteins playing a central role in disease processes PROTACs and their new mechanism of action are expected…
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Our review on advanced chemical genetics for epigenetics is now published in Current Opinion in Chemical Biology! Well done Andrew, Kwok-Ho and Michael! Read our review open access. Review synopsis In conventional chemical genetics, cell-active small-molecules…
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Alessio Ciulli is designated as the winner of the 2016 MedChemComm Emerging Investigator Lectureship. Learn more about the MedChemComm award. Alessio delivered his Prize lecture at the European Federation of Medicinal Chemistry International Symposium on Medicinal…