Ciulli Lab reveals how the E3 ligase SOCS2 latches on to its protein substrates.
Read full article on Nature Communications website.
Figure 1. Structural and interaction detail of the SBC-EpoR co-crystal
Figure 2. Structural and interaction detail of the SBC-GHR co-crystal structure
Figure 3. The BG loop of SOCS2
Figure 4. Conformational changes of the EF and BG loops
Figure 5. Position and characterization of SNPs of SOCS2
Figure 6. Comparison of the GHR and EpoR binding
Figure 7. Two models of SOCS2-substrate receptor recruitment
