New paper: Structure-guided design of peptides targeting the protein-protein interaction between Cullin-2 and Elongin BC adaptor in Cullin RING E3 ubiquitin ligases
Well done for this tour-de-force study to our BBSRC EastBio PhD student Andrew, to Kwok-Ho, Andrea, and to former Lab members Michael, Lars and Matt -with important contributions from our collaborators…
Our paper on the molecular recognition of helical histone tail by PHD finger domains is now published in Biochemical Journal. Well done to Alessio B., Anastasia, Xavi – and Manuel!…
Our paper reporting the first ternary crystal structure of a PROTAC bound to to its E3 ligase VHL and Brd4 target is now published in Nature Chemical Biology! Our work…
Our review on recognition and small-molecule mimicry of degrons by E3 ligases is now published in Current Opinion in Structural Biology. Well done Xavi! Read our review. Highlights: E3 ligases…
The article is a contribution to the journal’s Special Issue for the 2018 Tetrahedron Young Investigators Award for Matthew Fuchter. Read our article Open Access Congratulations Pedro and Xavi, well…
Read our Open Access article Congratulations to Anastasia, Xavi and colleagues! Gallery Thumbnail - Table of Graphics Gallery Thumbnail - Figure 1. Druggable pockets on BAZ2A/B PHD and validated fragments…
Read our paper open access here. The article will be published as part of the a Special Issue on “Inducing Protein Degradation as a Therapeutic Strategy“. Gallery Thumbnail - ToC Graphics Gallery…
The article will be part of the journal Special Issue on “Inducing Protein Degradation as a New Therapeutic Strategy”, edited by Prof. Craig Crews and Prof. Shameng Wang. Read our…
