Molecular recognition of ternary complexes for targeted protein degradation

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Well done for this tour-de-force study to our BBSRC EastBio PhD student Andrew, to Kwok-Ho, Andrea, and to former Lab members Michael, Lars and Matt -with important contributions from our collaborators…

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Our paper on the molecular recognition of helical histone tail by PHD finger domains is now published in Biochemical Journal. Well done to Alessio B., Anastasia, Xavi – and Manuel!…

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Our paper reporting the first ternary crystal structure of a PROTAC bound to to its E3 ligase VHL and Brd4 target is now published in Nature Chemical Biology! Our work…

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Our review on recognition and small-molecule mimicry of degrons by E3 ligases is now published in Current Opinion in Structural Biology. Well done Xavi! Read our review. Highlights: E3 ligases…

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The article is a contribution to the journal’s Special Issue for the 2018 Tetrahedron Young Investigators Award for Matthew Fuchter. Read our article Open Access Congratulations Pedro and Xavi, well…

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Read our Open Access article Congratulations to Anastasia, Xavi and colleagues! Gallery Thumbnail - Table of Graphics Gallery Thumbnail - Figure 1. Druggable pockets on BAZ2A/B PHD and validated fragments…

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Read our article open access Gallery Thumbnail - Graphical Abstract Gallery Thumbnail - Figure 1. Crystal Structure of the CRL2VHL Complex Gallery Thumbnail - Figure 2. The CRL2VHL Complex Is…

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Read our paper open access here. The article will be published as part of the a Special Issue on “Inducing Protein Degradation as a Therapeutic Strategy“. Gallery Thumbnail - ToC Graphics Gallery…

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Read our full paper open access Gallery Thumbnail - ToC: Cul2-based peptides Gallery Thumbnail - Figure 1. A) N-terminal tail in the Cullin family. B) The CRL2VHL complex Gallery Thumbnail…

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The article will be part of the journal Special Issue on “Inducing Protein Degradation as a New Therapeutic Strategy”, edited by Prof. Craig Crews and Prof. Shameng Wang. Read our…

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