Graphical AbstractFigure 1. Crystal Structure of the CRL2VHL ComplexFigure 2. The CRL2VHL Complex Is Dynamic and FlexibleFigure 3. Rbx1 Presents a New OrientationFigure 4. The Cul2-VBC Interface” title=”Figure 4. The Cul2-VBC InterfaceFigure 5. Biophysical Characterization of the Interaction between VBC and Cul2Figure6. Residues in the EloC Hydrophobic Pocket Reveal Criticality for the Strong Binding Affinity of Cul2-VBCFigure 7. Swapping Residues and Selectivity for Cul2 or Cul5