Senior Drug Discovery Scientist
Degree(s)
Bachelor of Biotechnology with Honours (2011), Monash University
Ph.D. Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology (2017), University of Melbourne
Staff email
Profile
Past Member To and From Dates: Post-Doctoral Scientist (Jan 2020-Apr 2021 & May 2023-Oct 2023) & Marie Skłodowska-Curie Individual Fellow (May 2021-Apr 2023)
Angus obtained his PhD in 2017 at the Walter and Eliza Hall Institute (Melbourne) under the supervision of Professors Peter Czabotar and Peter Colman, investigating the structure and function of pro-apoptotic BCL-2 family proteins. After a 2 year postdoc under Professor Czabotar working as part of a team collaborating with an industry partner to develop modulators of necroptosis, he joined the group of Professor Alessio Ciulli at the University of Dundee in January 2020. Supported by a Marie Skłodowska-Curie Fellowship, Angus’ research focused on structural and functional investigation of substrate receptors of CRL4 E3 ligases, with a view to exploiting them for targeted protein degradation with PROTACs and molecular glues. His work on structural and biophysical characterisation of DCAF11- and DCAF16-recruiting degrader molecules was part of a large collaborative effort that uncovered a novel modality in targeted protein degradation termed intramolecular bivalent glues. He joined the AC-BI collaboration team as a Senior Drug Discovery Scientist in Structural Biology and Biophysics in October 2023.
Outside of work, Angus is interested in many genres of music and enjoys travel, hiking, squash, swimming and watching Australian rules football.