Our paper interrogating the NMR binding detection limits of fragments targeting the VHL-HIF1α PPI

Category:2013, News
ByUoD Web Team
On11 Mar 2013

Read our paper published in ACS Med. Chem. Lett. about interrogating the NMR binding detection limits of fragments targeting the VHL-HIF1α PPI.

You can read our open-access paper.

Table of content graphic for NMR binding detection

Figure 1. Structural representation of the VCB multiprotein complex and the pVHL:HIF-1α interface

Figure 2. Binding detection at the pVHL:HIF-1α interface for fragment 4.

Figure 3. Detection of capped-Hydroxyproline 6 binding to VCB using ligand-based NMR spectroscopy

Figure 4. Group epitope mapping (GEM) obtained from STD-NMR for 6.

Figure 5. Residue specific mapping of the binding site of fragment 8 using 1H−15N HSQC