Lab News

All Sapkota Lab News on the MRC PPU website can be found here.

News Archive:

16 August 2023

Welcoming a new E3 ligase, KLHDC2, that can be harnessed for PROTACs. A collaborative effort with GSK, now published in Cell Chemical Biology.

2 February 2023

Luke Simpson and Luke Fulcher publish a method for targeted dephosphorylation of phospho-proteins in cells in Cell Chemical Biology.

20 October 2022

Luke and Lorraine’s paper on the impact of target protein localisation on the extent of TPD by PROTACs triggered a review by Singh and Dikic in Cell Chemical Biology.

25 September 2022

Our paper by Luke and Lorraine on the impact of target protein localisation on the extent of TPD was covered by Derek Lowe for Science!

https://www.science.org/content/blog-post/degraders-here-and-there

07 January 2021

https://www.ppu.mrc.ac.uk/news/karen-dunbar-sapkota-lab-mrc-ppu-uncovers-fam83f-mediator-cancer-promoting-wnt-signalling

07 December 2020

https://www.ppu.mrc.ac.uk/news/congratulations-mrc-ppu-pis-gopal-sapkota-and-satpal-virdee

03 August 2020

https://www.lifesci.dundee.ac.uk/news/2020/aug/3/alliance-launched-between-dundee-and-copenhagen-researchers-metabolism-and-cell

15 July 2020

https://www.thecourier.co.uk/fp/news/local/dundee/1442900/dundee-scientists-discover-how-to-destroy-undruggable-cancer-causing-protein/

https://www.fifetoday.co.uk/health/breakthrough-dundee-university-2915194

https://www.kirkintilloch-herald.co.uk/health/breakthrough-dundee-university-2915194

https://indianexpress.com/article/lifestyle/health/university-of-dundee-cancer-kras-6510964/

https://www.expresshealthcare.in/news/university-of-dundee-researchers-destroy-undruggable-cancer-causing-k-ras-protein/423434/

15 July 2020

Scientists destroy ‘undruggable’ cancer-causing protein

15 July 2020

Luke Simpson (PhD student in Sapkota Lab) develops an inducible protein degradation technology

15 July 2020

Sascha Roth from the Sapkota lab demonstrates targeted degradation of endogenous K-RAS

15 Jan 2020

Luke Fulcher (Sapkota Lab) awarded the Howard Elder Prize

July 31, 2019

Researchers make critical cell division discovery

Deadline News

Phys.org News

MRC-PPU News

That’s TV Scotland Coverage

May 22, 2018

Sapkota Lab describes a new paradigm in the regulation of the Casein Kinase 1 (CK1) family of protein kinases

April 23, 2018

Congratulations to Polyxeni Bozatzi, who defended her PhD thesis. Her external examiner was Prof. Trevor Dale (Cardiff University), while her internal examiner was Prof. Grahame Hardie. Well done, Dr. Bozatzi!

March 22, 2018

PAWS1 turns heads

PAWS1: Dundee University Press Release

PAWS1: EurekAlert News

PAWS1: News Medical Life Sciences coverage

January 15, 2018

Cells on the move: Tim Cummins and Kevin Wu (Sapkota lab) discover how the protein PAWS1 controls cellular skeleton and movement

Jun 6, 2017

SENS Antiaging research status today [Next Big Future]

May 26, 2017

Treating Diseases with a Protein Missile System [Leafscience.org]

May 11, 2017

AdPROM zeroes in on proteins  [The Evening Telegraph]

May 11, 2017

Scientists develop ‘missile’ drug development technique [The Courier and Advertiser]

May 10, 2017

Sapkota Lab Describes A ‘Protein Missile’ System To Destroy Endogenous Proteins In Cells

‘Protein missile‘ raises possibility of disease breakthroughs [Phys.Org]

‘Protein missile’ raises possibility of disease breakthroughs [http://healthmedicinet.com]

Oct 26, 2016

Sapkota Lab Publishes An Affinity-Directed PROtein Missile (AdPROM) System For Targeted Proteolysis Of Endogenous Proteins

Oct 10, 2016

The Poster Boys Of The MRC-PPU At The Annual PiCLS Symposium