Welcome to the Sapkota Laboratory

Our lab is interested in understanding how the TGFβ and Wnt signalling pathways are regulated during development and in adult cells, and how their misregulation causes human diseases. These pathways control a plethora of cellular processes and are often broken in many diseases, including skin and bone disorders, fibrosis and cancer. Therefore, a better understanding of their molecular regulation will lead to new opportunities for therapeutic intervention.

Our lab has ongoing collaborations with leading pharmaceutical industries (GlaxoSmithKline, Boehringer Ingelheim and Merck Serono) and leading academic laboratories, including those of Sir Jim Smith (The Francis Crick Institute) and Alex Bullock (University of Oxford).

Recently, we have identified a novel role for the FAM83 family of poorly characterised proteins in the regulation of CK1 family of Ser/Thr protein kinases. The CK1 family is known to control many cellular processes, including cell cycle progression, circadian rhythm, DNA-damage repair and Wnt and Shh signalling. However, how the CK1 family is regulated for it to impact so many cellular processes has remained a mystery. We want to understand precisely how the FAM83 family of proteins control the activity, subcellular distribution and substrate specificity of the CK1 family.

We not only apply cutting-edge technologies in biomedical research for our research but also constantly strive to develop new ones. Our group has developed an Affinity-directed PROtein Missile (AdPROM) system that allows us to rapidly destroy specific endogenous target proteins inside cells. We are interested in refining and exploiting this technology to potentially destroy disease-causing proteins from cells (for target validation) and tissues (for therapeutics).

We are constantly looking for enthusiastic and bright minds to join us and take on these challenges. In the process, we want to provide a world-class training for the next generation of researchers!

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The research in our lab is funded by