David H. Murray,
Principal Investigator and Sir Henry Dale Fellow
I did my undergraduate in Physics at North Carolina State University in the US. During this time, I became interested in membranes and their proteins, and after work in the lab of Prof. Keith Weninger, I went on to do my PhD in the subject. At the University of Virginia, I did my graduate studies in the lab of Prof. Lukas Tamm on the regulation and mechanism of membrane fusion protein clustering within membranes. Next, I picked up the methods of structural biology examining the retromer complex in the lab of Jim Hurley at the National Institutes of Health in Bethesda, Maryland (now UC Berkeley). Finally, in the lab of Marino Zerial at the Max Planck Institute for Molecular Cell Biology and Genetics I took on the cell biology of trafficking. Currently I drive an interdisciplinary synergy between these expertise to resolve outstanding questions in cell organization.
After completing my undergrad studies at the University of Bonn I continued with my Master’s thesis in the laboratory of Thorsten Lang to work on the clustering of transmembrane proteins in the plasma membrane. These studies sparked my interested in the interactions of proteins with membranes and I decided to continue along this path by doing a PhD in the laboratory of Elizabeth Smythe in Sheffield. During this time I worked intensely on Clathrin Mediated Endocytosis and was especially interested on the roles of the Clathrin light chains during this process. Now, during my Postdoctoral studies I aim to gain expertise in protein and lipid reconstitution in the laboratory of David Murray to answer exciting questions of membrane trafficking using a unique skillset to combine cell biology with modern protein reconstitution.
Hannes Maib, Filipe Ferreira, Stephane Vassilopoulos and Elizabeth Smythe (2018) “Cargo regulates clathrin-coated pit invagination via clathrin light chain phosphorylation”, Journal of Cell Biology, DOI: 10.1083/jcb.201805005
Hannes Maib, Elizabeth Smythe, and Kathryn Ayscough (2017) “Forty years on: clathrin-coated pits continue to fascinate”, Molecular Biology of the Cell DOI: 10.1091/mbc.E16-04-0213
MRC PhD student
CSC PhD student
MSci by Research student
MRC PhD rotation student
Jose Carlos Paredes,
Wellcome Trust PhD rotation student
Wellcome Trust rotation student