Multicellular organisms must organize their morphology and physical characteristics. Amidst changes to cell function and specialization, cells must maintain spatiotemporal regulation of communication. We aim to determine the molecular mechanisms of trafficking during dynamic responses to cell changes and specialization. We focus on polarized trafficking, a pathway responsible for intracellular and extracellular communication. These pathways and their components are fundamental, yet despite this importance, we do not understand the mechanisms enabling functional plasticity.
Our long-term vision is to determine the mechanisms by which communication responds to cell changes and cell specialization, enabling its targeted modulation.
We are grateful to the Wellcome Trust, The Royal Society, Tenovus Scotland, Medical Research Scotland, and the School of Life Sciences of the University of Dundee for funding our research.
We are housed in the Division of Cell and Developmental Biology and take advantage of the extraordinary resources of the School of Life Sciences at the University of Dundee.
