What We Study
Our group focuses on gene regulation and epigenetic reprogramming during mammalian development. We are particularly interested in how transcription factors drive cell-stage-specific gene regulatory networks through mammalian development. Following fertilization, cell potential gradually changes from totipotency to pluripotency or a differentiated state. However, the underlying mechanism of this process at the chromatin level remains poorly understood. To address this fundamental question across scales, from atoms to embryos, our group uses an interdisciplinary approach combining genomics, proteomics, biochemistry, and structural biology. We seek to unravel fundamental principles of gene regulation and epigenetic reprogramming in mammalian development and gain insights into defects in the process that affect fertility.