{"id":13,"date":"2021-11-17T17:05:13","date_gmt":"2021-11-17T17:05:13","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/sddc\/?page_id=13"},"modified":"2026-04-09T19:47:26","modified_gmt":"2026-04-09T18:47:26","slug":"front-page","status":"publish","type":"page","link":"https:\/\/sites.dundee.ac.uk\/sddc\/","title":{"rendered":"Structure Guided Drug Discovery Coalition (SDDC)"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Structure Guided Drug Discovery for Malaria and Tuberculosis<\/h2>\n\n\n\n<p>SDDC (Structure guided Drug Discovery Coalition)&nbsp;is an international collaboration led by the Drug Discovery Unit (<a style=\"color: #333333;\" href=\"https:\/\/www.drugdiscovery.dundee.ac.uk\/home\">DDU-Dundee<\/a>) at the University of Dundee-Scotland with&nbsp;researchers from the University of Washington, Seattle (<a style=\"color: #333333;\" href=\"https:\/\/www.ssgcid.org\/\">SSCGID-Seattle<\/a>), USA, the University of Chicago (CSBID<a style=\"color: #333333;\" href=\"https:\/\/csgid.org\/\">-Chicago<\/a>) , USA and University of Campinas (<a href=\"https:\/\/www.cqmed.unicamp.br\/about-us\/\">Centre of Medicinal Chemistry-UNICAMP<\/a>), Brazil. The coalition was granted $5M over the next 3 years (2Q 2024) by the Bill &amp; Melinda Gates Foundation.<\/p>\n\n\n\n<p>SDDC primary aim is to develop compounds to \u201cEarly Lead\u201d status, with Proof-of-Concept in animal models of infection for Malaria and Tuberculosis<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><img loading=\"lazy\" decoding=\"async\" width=\"1280\" height=\"235\" src=\"https:\/\/sites.dundee.ac.uk\/sddc\/wp-content\/uploads\/sites\/182\/2022\/01\/image1-4.png\" alt=\"Hit to early lead process from phenotypic hit to association to high value target, crystal structure, assay development, hit to lead strcutre guided drug discovery to early lead declaration\"><strong>Our Approach to speed up Malaria an Tuberculosis drug discovery process<\/strong><\/h2>\n\n\n\n<p>Medicinal Chemistry projects are focussed on the best disease-validated targets only.<\/p>\n\n\n\n<p>The projects preferably have protein-small molecule structures, enabling structure-guided medicinal chemistry.<\/p>\n\n\n\n<p><a role=\"button\" href=\"https:\/\/sites.dundee.ac.uk\/sddc\/scientific-approach\/\" target=\"_blank\" rel=\"noopener\">Learn more<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Our Collaborative Structure<\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"4005\" height=\"1155\" src=\"https:\/\/sites.dundee.ac.uk\/sddc\/wp-content\/uploads\/sites\/182\/2021\/11\/approach.png\" alt=\"\" class=\"wp-image-217\" srcset=\"https:\/\/sites.dundee.ac.uk\/sddc\/wp-content\/uploads\/sites\/182\/2021\/11\/approach.png 4005w, https:\/\/sites.dundee.ac.uk\/sddc\/wp-content\/uploads\/sites\/182\/2021\/11\/approach-300x87.png 300w, https:\/\/sites.dundee.ac.uk\/sddc\/wp-content\/uploads\/sites\/182\/2021\/11\/approach-1024x295.png 1024w, https:\/\/sites.dundee.ac.uk\/sddc\/wp-content\/uploads\/sites\/182\/2021\/11\/approach-768x221.png 768w, https:\/\/sites.dundee.ac.uk\/sddc\/wp-content\/uploads\/sites\/182\/2021\/11\/approach-1536x443.png 1536w, https:\/\/sites.dundee.ac.uk\/sddc\/wp-content\/uploads\/sites\/182\/2021\/11\/approach-2048x591.png 2048w, https:\/\/sites.dundee.ac.uk\/sddc\/wp-content\/uploads\/sites\/182\/2021\/11\/approach-624x180.png 624w\" sizes=\"auto, (max-width: 4005px) 100vw, 4005px\" \/><\/figure>\n\n\n\n<p><a role=\"button\" href=\"#\" target=\"_blank\" rel=\"noopener\"><br>Learn more<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>An international collaboration led by the Drug Discovery Unit<\/p>\n","protected":false},"author":131,"featured_media":505,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-13","page","type-page","status-publish","has-post-thumbnail","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/sddc\/wp-json\/wp\/v2\/pages\/13","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/sddc\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/sddc\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/sddc\/wp-json\/wp\/v2\/users\/131"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/sddc\/wp-json\/wp\/v2\/comments?post=13"}],"version-history":[{"count":252,"href":"https:\/\/sites.dundee.ac.uk\/sddc\/wp-json\/wp\/v2\/pages\/13\/revisions"}],"predecessor-version":[{"id":506,"href":"https:\/\/sites.dundee.ac.uk\/sddc\/wp-json\/wp\/v2\/pages\/13\/revisions\/506"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/sddc\/wp-json\/wp\/v2\/media\/505"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/sddc\/wp-json\/wp\/v2\/media?parent=13"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}