{"id":41,"date":"2018-01-25T21:13:46","date_gmt":"2018-01-25T21:13:46","guid":{"rendered":"http:\/\/sites.dev.dundee.ac.uk\/sapkota-lab\/?page_id=41"},"modified":"2025-04-28T13:05:55","modified_gmt":"2025-04-28T12:05:55","slug":"lab-news","status":"publish","type":"page","link":"https:\/\/sites.dundee.ac.uk\/sapkota-lab\/lab-news\/","title":{"rendered":"Lab News"},"content":{"rendered":"

All Sapkota Lab News on the MRC PPU website can be found here<\/a>.<\/h4>\n

News Archive:<\/h4>\n

28 April 2025 <\/strong><\/p>\n

In July 2024, the Herne Katha<\/em> team, who are renowned filmmakers from Nepal, visited the Sapkota lab to make a documentary on the lab’s research. The documentary, has been published recently and can be found on YouTube<\/a>. [Please note there may be adverts on YouTube. The Sapkota lab or the MRC PPU had no editorial input on the content]<\/em><\/p>\n

16 August 2024<\/h4>\n

Sapkota Lab Develops an Innovative Proximity-Inducing Small Molecule and Demonstrates Targeted Dephosphorylation (Link)<\/a><\/h3>\n

22 July 2023<\/h4>\n

Welcoming a new E3 ligase, KLHDC2, that can be harnessed for PROTACs. A collaborative effort with GSK, now published in Cell Chemical Biology<\/a>.<\/p>\n

2 February 2023<\/h4>\n

Luke Simpson and Luke Fulcher publish a method for targeted dephosphorylation of phospho-proteins in cells in Cell Chemical Biology<\/a>.<\/p>\n

20 October 2022<\/h4>\n

Luke and Lorraine’s paper on the impact of target protein localisation on the extent of TPD by PROTACs triggered a review by Singh and Dikic in Cell Chemical Biology<\/a>.<\/p>\n

25 September 2022<\/h4>\n

Our paper by Luke and Lorraine on the impact of target protein localisation on the extent of TPD was covered by Derek Lowe for Science!<\/a><\/p>\n

https:\/\/www.science.org\/content\/blog-post\/degraders-here-and-there<\/a><\/p>\n

07 January 2021<\/h4>\n

https:\/\/www.ppu.mrc.ac.uk\/news\/karen-dunbar-sapkota-lab-mrc-ppu-uncovers-fam83f-mediator-cancer-promoting-wnt-signalling<\/a><\/p>\n

07 December 2020<\/h4>\n

https:\/\/www.ppu.mrc.ac.uk\/news\/congratulations-mrc-ppu-pis-gopal-sapkota-and-satpal-virdee<\/a><\/p>\n

03 August 2020<\/h4>\n

https:\/\/www.lifesci.dundee.ac.uk\/news\/2020\/aug\/3\/alliance-launched-between-dundee-and-copenhagen-researchers-metabolism-and-cell<\/a><\/p>\n

15 July 2020<\/h4>\n

https:\/\/www.thecourier.co.uk\/fp\/news\/local\/dundee\/1442900\/dundee-scientists-discover-how-to-destroy-undruggable-cancer-causing-protein\/<\/a><\/p>\n

https:\/\/www.fifetoday.co.uk\/health\/breakthrough-dundee-university-2915194<\/a><\/p>\n

https:\/\/www.kirkintilloch-herald.co.uk\/health\/breakthrough-dundee-university-2915194<\/a><\/p>\n

https:\/\/indianexpress.com\/article\/lifestyle\/health\/university-of-dundee-cancer-kras-6510964\/<\/a><\/p>\n

https:\/\/www.expresshealthcare.in\/news\/university-of-dundee-researchers-destroy-undruggable-cancer-causing-k-ras-protein\/423434\/<\/a><\/p>\n

15 July 2020<\/h4>\n

Scientists destroy \u2018undruggable\u2019 cancer-causing protein<\/a><\/p>\n

15 July 2020<\/h4>\n

Luke Simpson (PhD student in Sapkota Lab) develops an inducible protein degradation technology<\/a><\/p>\n

15 July 2020<\/h4>\n

Sascha Roth from the Sapkota lab demonstrates targeted degradation of endogenous K-RAS<\/a><\/p>\n

15 Jan 2020<\/h4>\n

Luke Fulcher (Sapkota Lab) awarded the Howard Elder Prize<\/a><\/p>\n

July 31, 2019<\/h4>\n

Researchers make critical cell division discovery<\/a><\/p>\n

Deadline News<\/a><\/p>\n

Phys.org News<\/a><\/p>\n

MRC-PPU News<\/a><\/p>\n

That’s TV Scotland Coverage<\/a><\/p>\n

May 22, 2018<\/h4>\n

Sapkota Lab describes a new paradigm in the regulation of the Casein Kinase 1 (CK1) family of protein kinases<\/a><\/p>\n

April 23, 2018<\/h4>\n

Congratulations to Polyxeni Bozatzi, who defended her PhD thesis. Her external examiner was Prof. Trevor Dale (Cardiff University), while her internal examiner was Prof. Grahame Hardie. Well done, Dr. Bozatzi!<\/a><\/p>\n

March 22, 2018<\/h4>\n

PAWS1 turns heads<\/a><\/p>\n

PAWS1: Dundee University Press Release<\/a><\/p>\n

PAWS1: EurekAlert News<\/a><\/p>\n

PAWS1: News Medical Life Sciences coverage<\/a><\/p>\n

January 15, 2018<\/h4>\n

Cells on the move: Tim Cummins and Kevin Wu (Sapkota lab) discover how the protein PAWS1 controls cellular skeleton and movement<\/a><\/p>\n

Jun 6, 2017<\/span><\/h4>\n

SENS Antiaging research status today<\/a> [Next Big Future]<\/p>\n

May 26, 2017<\/span><\/h4>\n

Treating Diseases with a Protein Missile System [Leafscience.org]<\/a>
\n<\/span><\/p>\n

May 11, 2017<\/h4>\n

AdPROM zeroes in on proteins\u00a0 [The Evening Telegraph] <\/a><\/p>\n

May 11, 2017<\/h4>\n

Scientists develop ‘missile’ drug development technique [The Courier and Advertiser] <\/a><\/p>\n

May 10, 2017<\/h4>\n

Sapkota Lab Describes A \u2018Protein Missile\u2019 System To Destroy Endogenous Proteins In Cells<\/a><\/p>\n

‘Protein missile<\/em>‘ raises possibility of disease breakthroughs [<\/a>Phys.Org]<\/span><\/p>\n

\u2018Protein missile\u2019 raises possibility of disease breakthroughs<\/a> [http:\/\/healthmedicinet.com]<\/p>\n

Oct 26, 2016<\/h4>\n

Sapkota Lab Publishes An Affinity-Directed PROtein Missile (AdPROM) System For Targeted Proteolysis Of Endogenous Proteins<\/a><\/p>\n

Oct 10, 2016<\/h4>\n

The Poster Boys Of The MRC-PPU At The Annual PiCLS Symposium<\/a><\/p>\n

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Apr 30, 2015<\/h4>\n

A CRISPR way to advancing transcriptional and drug discovery studies<\/a><\/p>\n<\/div>\n

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Apr 15, 2015<\/h4>\n

Lina Herhaus from the Sapkota lab shows that phosphorylation sends the deubiquitylase OTUB1 to the nucleus<\/a><\/p>\n

May 21, 2014<\/h4>\n
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Sapkota lab publishes paper describing role of deubiquitylating enzyme USP15 on bone morphogenetic protein (BMP) signalling<\/a><\/p>\n<\/div>\n

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Feb 21, 2014<\/h4>\n

Janis Vogt, Ph.D. student in Gopal’s lab, publishes a paper on the discovery and functional characterisation of FAM83G\/PAWS1<\/a><\/p>\n<\/div>\n

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Jan 30, 2014<\/h4>\n

2013 Tim Hunt prize for Cell Biology awarded to Lina Herhaus<\/a><\/p>\n<\/div>\n

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Sep 27, 2013<\/h4>\n

PhD student in Gopal Sapkota’s lab publishes paper on the role of OTUB1 in TGF-beta signalling in Nature Communications<\/a>.<\/p>\n

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Jun 21, 2013<\/h4>\n

TGF-beta Activated Kinase 1 (TAK1): A misnomer?<\/a><\/p>\n<\/div>\n

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Jun 20, 2012<\/h4>\n

Mazin Al-Salihi publishes the role of USP11, a deubiquitylating enzyme, in the regulation of the TGF-beta pathway<\/a><\/p>\n

Jun 09, 2010<\/h4>\n

Abdulla Ibrahim awarded the Pathological Society of Great Britain and Ireland bursary<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

All Sapkota Lab News on the MRC PPU website can be found here. News Archive: 28 April 2025 In July 2024, the Herne Katha team, who are renowned filmmakers from Nepal, visited the Sapkota lab to make a documentary on the lab’s research. The documentary, has been published recently and can be found on YouTube. […]<\/p>\n","protected":false},"author":329,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-41","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/sapkota-lab\/wp-json\/wp\/v2\/pages\/41","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/sapkota-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/sapkota-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/sapkota-lab\/wp-json\/wp\/v2\/users\/329"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/sapkota-lab\/wp-json\/wp\/v2\/comments?post=41"}],"version-history":[{"count":17,"href":"https:\/\/sites.dundee.ac.uk\/sapkota-lab\/wp-json\/wp\/v2\/pages\/41\/revisions"}],"predecessor-version":[{"id":427,"href":"https:\/\/sites.dundee.ac.uk\/sapkota-lab\/wp-json\/wp\/v2\/pages\/41\/revisions\/427"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/sapkota-lab\/wp-json\/wp\/v2\/media?parent=41"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}