Scientific Papers

Assessment of 105 patients with angiotensin converting enzyme-inhibitor induced angioedema
Eva Rye Rasmussen, Christian Von Buchwald, Mia Wadelius, Sumangali Chandra Prasad, Shailajah Kamaleswaran, Kawa Khaled Ajgeiy, Georg Authried, Kristine Appel U Pallesen, and Anette Bygum International Journal of Otolaryngology [Epub ahead of print]

Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population.
Hallberg P, Persson M, Axelsson T, Cavalli M, Norling P, Johansson HE, Yue QY, Magnusson PK, Wadelius C, Eriksson N, Wadelius M. Pharmacogenomics. 2017 Jan 13. doi: 10.2217/pgs-2016-0184. [Epub ahead of print]

Meta-analysis of genome-wide association studies on the intolerance of angiotensin-converting enzyme inhibitors.
Mahmoudpour SH, Veluchamy A, Siddiqui MK, Asselbergs FW, Souverein PC, de Keyser CE, Hofman A, Lang CC, Doney AS, Stricker BH, de Boer A, Maitland-van der Zee AH, Palmer CN; on behalf of the PREDICTION-ADR consortium. Pharmacogenet Genomics. 2016 Dec 26. doi: 10.1097/FPC.0000000000000264. [Epub ahead of print]

Comparison of clinical factors between patients with angiotensin-converting enzyme inhibitor-induced angioedema and cough.
Hallberg P, Nagy J, Karawajczyk M, Nordang L, Islander G, Norling P, Johansson HE, Kämpe M, Hugosson S, Yue QY, Wadelius M. Ann Pharmacother. 2016 Nov 25. pii: 1060028016682251. [Epub ahead of print]

Determinants of angiotensin converting enzyme-inhibitor (ACEI) intolerance and angioedema in the UK clinical practice research datalink.
Mahmoudpour SH, Baranova EV, Souverein PC, Asselbergs FW,  de Boer A, Maitland-van der Zee AH; PREDICTION-ADR consortium.
Br J Clin Pharmacol. 2016 Dec. 82(6):1647-1659 doi: 10.1111/bcp.13090. Epub 2016 Oct 4

A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough.
Mosley JD, Shaffer CM, Van Driest SL, Weeke PE, Wells QS, Karnes JH, Velez Edwards DR, Wei WQ, Teixeira PL, Bastarache L, Crawford DC, Li R, Manolio TA, Bottinger EP, McCarty CA, Linneman JG, Brilliant MH, Pacheco JA, Thompson W, Chisholm RL, Jarvik GP, Crosslin DR, Carrell DS, Baldwin E, Ralston J, Larson EB, Grafton J, Scrol A, Jouni H, Kullo IJ, Tromp G, Borthwick KM, Kuivaniemi H, Carey DJ, Ritchie MD, Bradford Y, Verma SS, Chute CG, Veluchamy A, Siddiqui MK, Palmer CN, Doney A, MahmoudPour SH, Maitland-van der Zee AH, Morris AD, Denny JC, Roden DM.
Pharmacogenomics J. 2015 Jul 14. doi: 10.1038/tpj.2015.51. Epub 2015 Jul 14

Continuation of angiotensin converting enzyme inhibitor therapy, in spite of occurrence of angioedema.
Mahmoudpour SH, Asselbergs FW, Terreehorst I, Souverein PC, de Boer A, Maitland-van der Zee AH.
Int J Cardiol.
  2015 Dec 15;201:644-5. doi: 10.1016/j.ijcard.2015.08.185. Epub 2015 Aug 25.

Change in prescription pattern as a potential marker for adverse drug reactions of angiotensin converting enzyme inhibitors.
Mahmoudpour SH, Asselbergs FW, de Keyser CE, Souverein PC, Hofman A, Stricker BH, de Boer A, Maitland-van der Zee AH.
Int J Clin Pharm.
 2015 Dec;37(6):1095-103. doi: 10.1007/s11096-015-0159-3. Epub 2015 Jul 10.

Phenotype Standardization for Statin-Induced Myotoxicity.
Alfirevic A, Neely D, Armitage J, Chinoy H, Cooper RG, Laaksonen R, Carr DF, Bloch KM, Fahy J, Hanson A, Yue QY, Wadelius M, Maitland-van Der Zee AH, Voora D, Psaty BM, Palmer CN, Pirmohamed M.
Clin Pharmacol Ther. 2014 Oct;96(4):470-6. doi: 10.1038/clpt.2014.121. Epub 2014 Jun 4

Phenotype standardisation of angioedema in the head and neck region caused by agents acting on the angiotensin system.
Wadelius M, E Marshall S, Islander G, Nordang L, Karawajczyk M, Yue QY, Terreehorst I, Baranova EV, Hugosson S, Sköldefors K, Pirmohamed M, van der Zee AH, Alfirevic A, Hallberg P,  Palmer CN.
Clin Pharmacol Ther. 2014 Oct;96(4):477-81. doi: 10.1038/clpt.2014.138. Epub 2014 Jun 24

The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1 and Simvastatin-Induced Myopathy: 2014 Update.
Ramsey LB, Johnson SG, Caudle KE, Haidar CE, Voora D, Wilke RA, Maxwell WD, McLeod HL, Krauss RM, Roden DM, Feng Q, Cooper-DeHoff RM, Gong L, Klein TE, Wadelius M, Niemi M.
Clin Pharmacol Ther. 2014 Oct;96(4):423-8. doi: 10.1038/clpt.2014.125. Epub 2014 Jun 11

Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process.
Caudle KE, Klein TE, Hoffman JM, Muller DJ, Whirl-Carrillo M, Gong L, McDonagh EM, Sangkuhl K, Thorn CF, Schwab M, Agundez JA, Freimuth RR, Huser V, Lee MT, Iwuchukwu OF, Crews KR, Scott SA, Wadelius M, Swen JJ, Tyndale RF, Stein CM, Roden D, Relling MV, Williams MS, Johnson SG.
Curr Drug Metab. 2014 Feb;15(2):209-17.

Conference Presentations

Patterns of Angiotensin Converting Enzyme Inhibitor Prescriptions for Different Indications: A Population-based Study.
Seyed Hamidreza Mahmoudpour, Folkert W Asselbergs, Patrick C Souverein,  Anthonius de Boer,  Anke-Hilse Maitland-van der Zee.
31st International Conference on Pharmacoepidemiology & Therapeutic Risk Management, August 22-26, 2015
Hynes Convention Center, Boston, MA USA

Statin-induced myotoxicity – EU PREDICTION-ADR Project.
Carr DF, Van Staa T, Chinoy, H, Cooper RG, Fahy J, Hanson A, Bloch K,Wadelius M, Maitland van der Zee AH, Palmer C, Pirmohamed M, Alfirevic A.
First International Conference on Myositis, May 8-11, 2015, Radisson Blu Park Hotel, Stockholm, Sweden

Discontinuation of Angiotensin Converting Enzyme Inhibitors (ACEIs) as a Potential Marker for Adverse Drug Reactions (ADRs).
Seyed Hamidreza Mahmoud Pour, Catherine E de Keyser, Patrick C Souverein,  Folkert W Asselbergs, Albert Hofman, Bruno H Stricker,  Anthonius de Boer,  Anke-Hilse Maitland-van der Zee.
30th International Conference on Pharmacoepidemiology & Therapeutic Risk Management, Oct 24-27, 2014
Taipei International Convention Center

Book Chapters

None at this time

General Information

PREDICTION ADR Newsletter No2 published October 2015

PREDICTION ADR Newsletter No1 published September 2014

The Tayside Spare Blood Study: GoSHARE.