Publications

Moraga, I., Richter, D., Wilmes, S., Winkelmann, H., Jude, K., Thomas, C., Suhoski, M.M., Engleman, E.G., Piehler, J., and Garcia, K.C. (2015a). Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency. Science Signaling 8, ra114.

Moraga, I., Wernig, G., Wilmes, S., Gryshkova, V., Richter, C.P., Hong, W.J., Sinha, R., Guo, F., Fabionar, H., Wehrman, T.S., et al. (2015b). Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands. Cell 160, 1196-1208.

Spangler, J.B., Moraga, I., Mendoza, J.L., and Garcia, K.C. (2015). Insights into cytokine-receptor interactions from cytokine engineering. Annual Review of Immunology 33, 139-167.

Moraga, I., Spangler, J., Mendoza, J.L., and Garcia, K.C. (2014). Multifarious determinants of cytokine receptor signaling specificity. Advances in Immunology 121, 1-39.

Ring, A.M., Lin, J.X., Feng, D., Mitra, S., Rickert, M., Bowman, G.R., Pande, V.S., Li, P., Moraga, I., Spolski, R., et al. (2012). Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nature Immunology 13, 1187-1195.

Junttila, I.S. § ,  Creusot, R.J. § , Moraga, I. § , Bates, D.L. § , Wong, M.T., Alonso, M.N., Suhoski, M.M., Lupardus, P., Meier-Schellersheim, M., Engleman, E.G., et al. (2012). Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines. Nature Chemical Biology 8, 990-998. §  These authors contributed equally to this work

Levin, A.M., Bates, D.L., Ring, A.M., Krieg, C., Lin, J.T., Su, L., Moraga, I., Raeber, M.E., Bowman, G.R., Novick, P., et al. (2012). Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’. Nature 484, 529-533.

Gakovic, M., Shu, X., Kasioulis, S., Moraga, I., and Wright, A.F. (2011). The role of RPGR in cilia formation and actin stability. Human Molecular Genetics 20, 4840-4850.

Thomas, C., Moraga, I., Levin, D., Krutzik, P.O., Podoplelova, Y., Trejo, A., Lee, C., Yarden, G., Vleck, S.E., Glenn, J.S., et al. (2011). Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell 146, 621-632.

Lalanne, A.I., Moraga, I., Hao, Y., Pereira, J.P., Alves, N.L., Huntington, N.D., Freitas, A.A., Cumano, A., and Vieira, P. (2010). CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism. Journal of Immunology 184, 5678-5685.

Moraga, I.Harari, D., Schreiber, G., Uze, G., and Pellegrini, S. (2009). Receptor density is key to the alpha2/beta interferon differential activities. Molecular and Cellular Biology 29, 4778-4787.

Merino, E., Avila-Flores, A., Shirai, Y., Moraga, I., Saito, N., and Merida, I. (2008). Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells. Journal of Immunology 180, 5805-5815.

Merino, E., Sanjuan, M.A., Moraga, I., Cipres, A., and Merida, I. (2007). Role of the diacyl-glycerol kinase alpha-conserved domains in membrane targeting in intact T cells. The Journal of Biological Chemistry 282, 35396-35404.