Aberrant DNA methylation in blood cancer
Great work by PhD candidate Ieva Budriunaite. Ieva was selected to give a plenary talk and present her poster at the recent AACR conference “DNA methylation, Clonal Hematopoiesis, and Cancer” in San Diego, US. Here, she discussed her work on the effects of common chemotherapeutic drugs in expansion of clonal hematopoiesis driver mutations, and how this may increase the risk of therapy-related hematological malignancies.
The work has been published in Genes & Development in their November issue. Great work by Anna and rest in figuring out how loss of PROSER1 and TOPD (TET-OGT-PROSER1-DBHS proteins) complexes influence DNA methylation and gene expression in early development.
https://genesdev.cshlp.org/content/38/21-24/952.long
A warm welcome to Phoebe Crawley – a talented student supported by a 4-year EASTBIO PhD studentship. Hope you will settle in well in Dundee.
Xiang finished her MSci degree succesfully and stayed around for another few months as a research assistant but now it is time to move on. Best of luck in the future and we hope to see you again!
If anyone is interested in looking at TET protein localization in the genome have a look at “ChIP-sequencing of TET proteins” in the new Methods in Molecular Biology volume 2272.
https://pubmed.ncbi.nlm.nih.gov/34009619/
See news coverage from STV here: https://www.youtube.com/watch?v=pfBQNQkL2aE
