{"id":618,"date":"2013-09-16T21:58:57","date_gmt":"2013-09-16T21:58:57","guid":{"rendered":"http:\/\/blog.dundee.ac.uk\/ian-gilbert\/?page_id=618"},"modified":"2015-02-16T08:50:56","modified_gmt":"2015-02-16T08:50:56","slug":"papers-2009","status":"publish","type":"page","link":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/papers-2009\/","title":{"rendered":"Papers 2009"},"content":{"rendered":"

Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei. Spinks, D.; Shanks, E. J.; Cleghorn, L. A. T.; McElroy, S.; Jones, D.; James, D.; Fairlamb, A. H.; Frearson, J. A.; Wyatt, P. G.; Gilbert, I. H. ChemMedChem, 2009, 4, 2060-2069.\"link<\/a> \"link<\/a><\/p>\n

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis. Torrie, L. S.; Wyllie, S.; Spinks, D.; Oza, S. L.; Thompson, S.; Harrison, J. R.; Gilbert, I. H.; Wyatt, P. G.; Fairlamb, A. H.; Frearson, J. A. J. Biol. Chem., 2009, 52, 36137-36145.\"link<\/a> \"link<\/p>\n

Thiolactomycin analogues as potential anti-Toxoplasma gondii agent. Martins-Duarte, E. S.; Jones, S. M.; Gilbert, I. H.; Atella, G. C.; de Souza, W.; Vommaro, R. C. Parasitol. Int., 2009, 58, 411-415.\"link<\/a> \"link<\/a><\/p>\n

SAR studies on azasterols as potential anti-trypanosomal and anti-leishmanial agents. Gigante, F.; Kaiser, M.; Brun, R.; Gilbert, I. H. Bioorg. Med. Chem., 2009, 17, 5950-5961.\"link<\/a> \"link<\/a><\/p>\n

Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase. Patterson, S.; Jones, D. C.; Shanks, E. J.; Frearson, J. A.; Gilbert, I. H.; Wyatt, P. G.; Fairlamb, A. H.. ChemMedChem, 2009, 4, 1341-1353.\"link<\/a> \"link<\/a><\/p>\n

One Scaffold, Three Binding Modes. Mpamhanga, C. P.; Spinks, D.; Tulloch, L. B.; Shanks, E.; Robinson, D.; Collie, I.; Fairlamb, A. H.; Wyatt, P. G.; Frearson, J. A.; Hunter, W. N.; Gilbert, I. H.; Brenk, R. J. Med. Chem., 2009, 52, 4454-4465.\"link<\/a> \"link<\/a><\/p>\n

Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis. Richardson, J. L.; Nett, I. R. E.; Jones, D. C.; Abdille, M. H.; Gilbert, I. H.; Fairlamb, A. H. ChemMedChem, 2009, 4, 1333-1340.\"link<\/a> \"link<\/a><\/p>\n

Targeted delivery of compounds to Trypanosoma brucei using the melamine motif. Chollet, C.; Baliani, A.; Wong, P. E.; Barrett, M. P.; Gilbert, I. H. Bioorg. Med. Chem., 2009, 17, 2512-2523.\"link<\/a> \"link<\/a><\/p>\n

Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites. Baliani, A.; Peal, V.; Gros, L.; Brun, R.; Kaiser, M.; Barrett, M. P.; Gilbert, I. H. Org. Biomol. Chem., 2009, 7, 1154-1166.\"link<\/a> \"link<\/a><\/p>\n

N-(2-hydroxypropyl)methacrylamide (HPMA) – amphotericin B copolymer conjugates as anti-leishmanial agents. Nicoletti, S.; Seifert, K.; Gilbert, I. H. Int. J. Antimicrob. Agents, 2009, 33, 441-448.\"link<\/a> \"link<\/a><\/p>\n

Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase. McCarthy, O.; Musso-Buendia, A.; Kaiser, M.; Brun, R.; Ruiz-Perez, L. M.; Johansson, N. G.; Pacanowska, D. G.; Gilbert, I. H. Eur. J. Med. Chem., 2009, 44, 678-688.\"link<\/a> \"link<\/a><\/p>\n

Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni. Musso-Buendia, J. A.; Vidal, A.E., Kasinthan, G.; Nguyen, C.; Carrero-Lerida, J.; Ruiz-Perez, L. M.; Wilson, K.; Johansson, N. G.; Gilbert, I. H.; Gonzalez-Pacanowska, D. J. Enzyme Inhib. Med. Chem., 2009, 24, 111-116.\"link<\/a> \"link<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei. Spinks, D.; Shanks, E. J.; Cleghorn, L. A. T.; McElroy, S.; Jones, D.; James, D.; Fairlamb, A. H.; Frearson, J. A.; Wyatt, P. G.; Gilbert, I. H. ChemMedChem, 2009, 4, 2060-2069. Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis. Torrie, […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"full-width-page.php","meta":{"footnotes":""},"class_list":["post-618","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages\/618","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/comments?post=618"}],"version-history":[{"count":1,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages\/618\/revisions"}],"predecessor-version":[{"id":1020,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages\/618\/revisions\/1020"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/media?parent=618"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}