{"id":1579,"date":"2018-08-20T07:17:56","date_gmt":"2018-08-20T07:17:56","guid":{"rendered":"http:\/\/sites.dundee.ac.uk\/ian-gilbert\/?page_id=1579"},"modified":"2018-08-20T09:20:48","modified_gmt":"2018-08-20T09:20:48","slug":"papers2018","status":"publish","type":"page","link":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/papers2018\/","title":{"rendered":"Papers 2018"},"content":{"rendered":"<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0960894X18306681\" target=\"_blank\" rel=\"noopener\">2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas&#8217; disease<\/a>. Thomas, M. G.; De Rycker, M.; Cotillo Torrejon, I.; Thomas, J.; Riley, J.; Spinks, D.; Read, K. D.; Miles, T. J.; Gilbert, I. H.; Wyatt, P. G. <em>Bioorg. Med. Chem. Lett.; <\/em><strong>2018<\/strong>, in press. PMID: 30104093<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41586-018-0356-z\" target=\"_blank\" rel=\"noopener\">Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis<\/a>. Wyllie, S.; Thomas, M.; Patterson, S.; Crouch, S.; De Rycker, M.; Lowe, R.; Gresham, S.; Urbaniak, M. D.; Otto, T. D.; Stojanovski, L.; Simeons, F. R. C.; Manthri S1, MacLean LM1, Zuccotto F1, Homeyer N1, Pflaumer H7, Boesche M7, Sastry L1, Connolly, P.; Albrecht, S.; Berriman, M.; Drewes, G.; Gray, D. W.; Ghidelli-Disse, S.; Dixon, S.; Fiandor, J. M.; Wyatt, P. G.; Ferguson, M. A. J.; Fairlamb, A. H.; Miles, T. J.; Read, K. D.; Gilbert, I. H. <em>Nature, <\/em><strong>2018<\/strong><em>, 560,<\/em> 192-197. PMID: 30046105<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41586-018-0327-4\" target=\"_blank\" rel=\"noopener\">Challenges and recent progress in drug discovery for tropical diseases.<\/a> De Rycker, M.; Baragana, B.; Duce, S. L.; Gilbert, I. H. <em>Nature<\/em>, <strong>2018<\/strong>, <em>559<\/em>, 498-506.<\/p>\n<p><a href=\"https:\/\/aac.asm.org\/content\/62\/8\/e00235-18.long\" target=\"_blank\" rel=\"noopener\">Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals.<\/a> Wall, R. J.; Moniz, S.; Thomas, M. G.; Norval, S.; Ko, E. J.; Marco, M.; Miles, T. J.; Gilbert, I. H.; Horn, D.; Fairlamb A. H.; Wyllie S. <em>Antimicrob. Agents Chemother. <\/em><strong>2018<\/strong><em>, 62, <\/em>xxx-xxx. PMID: 29844044<\/p>\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/cbdd.13129\" target=\"_blank\" rel=\"noopener\">Exhaustive sampling of the fragment space associated to a molecule leading to the generation of conserved fragments<\/a>. Heikamp, K.; Zuccotto, F.; Kiczun, M.; Ray, P. Gilbert, I. H. <em>Chem. Biol. Drug Des.<\/em> <strong>2018<\/strong>, <em>91<\/em>, 655-667.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas&#8217; disease. Thomas, M. G.; De Rycker, M.; Cotillo Torrejon, I.; Thomas, J.; Riley, J.; Spinks, D.; Read, K. D.; Miles, T. J.; Gilbert, I. H.; Wyatt, P. G. Bioorg. Med. Chem. Lett.; 2018, in press. PMID: 30104093 Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis. Wyllie, [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"full-width-page.php","meta":{"footnotes":""},"class_list":["post-1579","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages\/1579","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/comments?post=1579"}],"version-history":[{"count":10,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages\/1579\/revisions"}],"predecessor-version":[{"id":1595,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages\/1579\/revisions\/1595"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/media?parent=1579"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}