{"id":1577,"date":"2018-08-20T07:17:12","date_gmt":"2018-08-20T07:17:12","guid":{"rendered":"http:\/\/sites.dundee.ac.uk\/ian-gilbert\/?page_id=1577"},"modified":"2018-08-20T18:57:45","modified_gmt":"2018-08-20T18:57:45","slug":"papers2017","status":"publish","type":"page","link":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/papers2017\/","title":{"rendered":"Papers 2017"},"content":{"rendered":"

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors<\/a>. Bayliss, T.; Robinson, D. A.; Smith, V. C.; Brand, S.; McElroy, S. P.; Torrie, L. S.; Mpamhanga, C.; Norval, S.; Stojanovski, L.; Brenk, R.; Frearson, J. A.; Read, K. D.; Gilbert, I. H.; Wyatt, P. G. J. Med. Chem., <\/em>2017<\/strong>, 60, <\/em>9790-9806. PMCID: PMC5734605<\/p>\n

Screening a protein kinase inhibitor library against Plasmodium falciparum<\/a>. Hallyburton, I.; Grimaldi, R.; Woodland, A.; Baraga\u00f1a, B; Luksch, T; Spinks, D; James, D; Leroy, D; Waterson, D; Fairlamb, A. H.; Wyatt, P. G.; Gilbert, I. H.; Frearson, J. A. Malar. J.<\/em> 2017<\/strong>, 16<\/em>, 446.<\/p>\n

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani<\/a>. Torrie, L. S.; Brand, S.; Robinson, D. A.; Ko, E. J.; Stojanovski, L.; Simeons, F. R. C.; Wyllie, S.; Thomas, J.; Ellis, L.; Osuna-Cabello, M.; Epemolu, O.; N\u00fchs, A.; Riley, J.; MacLean, L.; Manthri, S.; Read, K. D.; Gilbert, I. H.; Fairlamb, A. H.; De Rycker. M. ACS Infect Dis.<\/em> 2017<\/strong>, 3<\/em>, 718-727.<\/p>\n

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi<\/em><\/a>. Brand, S.; Ko, E. J.; Viayna, E.; Thompson, S.; Spinks, D.; Thomas, M.; Sandberg, L.; Francisco, A. F.; Jayawardhana, S.; Smith, V. C.; Jansen, C.; De Rycker, M.; Thomas, J.; MacLean, L.; Osuna-Cabello, M.; Riley, J.; Scullion, P.; Stojanovski, L.; Simeons, F. R. C.; Epemolu, O.; Shishikura, Y.; Crouch, S. D.; Bakshi, T. S.; Nixon, C. J.; Reid, I. H.; Hill, A. P.; Underwood, T. Z.; Hindley, S. J.; Robinson, S. A.; Kelly, J. M.; Fiandor, J. M.; Wyatt, P. G.; Marco, M.; Miles, T. J.; Read, K. D.; Gilbert, I. H. J. Med. Chem, <\/em>2017, 60, 7284-7299. PMCID: PMC5601362<\/p>\n

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need<\/a>. Field, M. C.; Horn, D.; Fairlamb, A. H.; Ferguson, M. A.; Gray, D. W.; Read, K. D.; De Rycker, M.; Torrie L. S.; Wyatt, P. G.; Wyllie, S.; Gilbert, I. H. Nat Rev Microbiol<\/em>. 2017, 15<\/em>, 217-231<\/p>\n

Fragment library design, synthesis and expansion: nurturing a synthesis and training platform<\/a>. Ray, P. C.; Kiczun, M.; Huggett, M.; Lim, A.; Prati, F.; Gilbert, I. H.; Wyatt, P. G. Drug Discov. Today<\/em>, 2017, 22<\/em>, 43-56.<\/p>\n

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase<\/a>. Nakazawa Hewitt, S.; Dranow, D. M.; Horst, B. G.; Abendroth, J. A.; Forte, B.; Hallyburton, I.; Jansen, C.; Baragana, B,l Choi, R.; Rivas, K. L.; Hulverson, M. A.; Dumais, M.; Edwards, T. E.; Lorimer, D. D.; Fairlamb, A. H.; Gray, D. W.; Read, K. D.; Lehane, A. M.; Kirk, K.; Myler, P. J.; Werniment, A.; Walpole, C. S.; Stacy, R.; Barrett, L. K.; Gilbert, I. H.; Van Voorhis, W. C. ACS Infect. Dis. <\/em>2017, 3,<\/em> 34-44.<\/em><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors. Bayliss, T.; Robinson, D. A.; Smith, V. C.; Brand, S.; McElroy, S. P.; Torrie, L. S.; Mpamhanga, C.; Norval, S.; Stojanovski, L.; Brenk, R.; Frearson, J. A.; Read, K. D.; Gilbert, I. H.; Wyatt, P. G. J. Med. Chem., 2017, 60, 9790-9806. PMCID: PMC5734605 Screening a […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"full-width-page.php","meta":{"footnotes":""},"class_list":["post-1577","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages\/1577","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/comments?post=1577"}],"version-history":[{"count":9,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages\/1577\/revisions"}],"predecessor-version":[{"id":1613,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages\/1577\/revisions\/1613"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/media?parent=1577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}