{"id":1573,"date":"2018-08-20T07:11:36","date_gmt":"2018-08-20T07:11:36","guid":{"rendered":"http:\/\/sites.dundee.ac.uk\/ian-gilbert\/?page_id=1573"},"modified":"2018-08-20T18:59:20","modified_gmt":"2018-08-20T18:59:20","slug":"papers2015","status":"publish","type":"page","link":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/papers2015\/","title":{"rendered":"Papers 2015"},"content":{"rendered":"

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei<\/em><\/a>. Cleghorn, L. A.; Albrecht, S.; Stojanovski, L.; Simeons, F. R.; Norval, S.; Kime, R.; Collie, I. T.; De Rycker, M.; Campbell, L.; Hallyburton, I.; Frearson, J. A.; Wyatt, P. G.; Read, K. D.; Gilbert, I. H. J Med Chem<\/em>. 2015, 58, 7695-7706. PMCID: PMC4601051<\/p>\n

Discovery and optimisation studies of antimalarial phenotypic hits<\/a>. Mital, A.; Murugesan, D.; Kaiser, M.; Yeates, C.; Gilbert, I. H. Eur J. Med. Chem<\/em>. 2015, 103<\/em>, 530-538.<\/p>\n

Development of Small-Molecule Trypanosoma brucei<\/em> N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode<\/a>. Spinks, D.; Smith, V.; Thompson, S.; Robinson, D. A.; Luksch, T.; Smith, A.; Torrie, L. S.; McElroy, S.; Stojanovski, L.; Norval, S.; Collie, I. T.; Hallyburton, I.; Rao, B.; Brand, S.; Brenk, R.; Frearson, J. A.; Read, K. D.; Wyatt, P. G.; Gilbert, I. H. ChemMedChem<\/em>. 2015, 10<\/em>, 1821-1836. PMCID: PMC4648043<\/p>\n

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library<\/a>. Woodland, A.; Thompson, S.; Cleghorn, L. A.; Norcross, N.; De Rycker, M.; Grimaldi, R.; Hallyburton, I.; Rao, B.; Norval, S.; Stojanovski, L.; Brun, R.; Kaiser, M.; Frearson, J. A.; Gray, D. W.; Wyatt, P. G.; Read, K. D.; Gilbert, I. H. ChemMedChem<\/em>. 2015, 10<\/em>, 1809-1820. PMCID: PMC4648050<\/p>\n

A novel multiple-stage antimalarial agent that inhibits protein synthesis<\/a>. Baraga\u00f1a, B.; Hallyburton, I.; Lee, M. C.; Norcross, N. R.; Grimaldi, R.; Otto, T. D.; Proto, W. R.; Blagborough, A. M.; Meister, S.; Wirjanata, G.; Ruecker, A.; Upton, L. M.; Abraham, T. S.; Almeida, M. J.; Pradhan, A.; Porzelle, A.; Mart\u00ednez, M. S.; Bolscher, J. M.; Woodland, A.; Norval, S.; Zuccotto, F.; Thomas, J.; Simeons, F.; Stojanovski, L.; Osuna-Cabello, M.; Brock, P. M.; Churcher, T. S.; Sala, K. A.; Zakutansky, S. E.; Jim\u00e9nez-D\u00edaz, M. B.; Sanz, L. M.; Riley, J.; Basak, R.; Campbell, M.; Avery, V. M.; Sauerwein, R. W.; Dechering, K. J.; Noviyanti, R.; Campo, B.; Frearson, J. A.; Angulo-Barturen, I.; Ferrer-Bazaga, S.; Gamo, F. J.; Wyatt, P. G.; Leroy, D.; Siegl, P.; Delves, M. J.; Kyle, D. E.; Wittlin, S.; Marfurt, J.; Price, R. N.; Sinden, R. E.; Winzeler, E. A.; Charman, S. A.; Bebrevska, L.; Gray, D. W.; Campbell, S.; Fairlamb, A. H.; Willis, P. A.; Rayner, J. C.; Fidock, D. A.; Read, K. D.; Gilbert, I.H. Nature<\/em>, 2015<\/strong>, 522<\/em>, 315-320. PMCID: PMC4700930<\/p>\n

Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability<\/a>. Henderson, C. J.; McLaughlin, L. A.; Osuna-Caello, M.; Taylor, M.; Gilbert, I. H.; McLaren, A. W.; Wolf, C. R. Biochem. J.,<\/em> 2015<\/strong>, 465<\/em>, 479-488.<\/p>\n

Application of RNAi to genomic drug target validation in schistosomes<\/a>. Guidi, A.; Mansour, N. R.; Paveley, R.; Carruthers, I. M.; Besnard, J.; Hopkins, A. L.; Gilbert, I. H.; Quentin D. Bickle, Q. D. PLoS Negl. Trop. Dis.<\/em>, 2015<\/strong>, 9<\/em>, e0003801.<\/p>\n

N-Myristoyltransferase is a cell wall target in Aspergillus fumigatus<\/em>.<\/a> Fang, W.; Robinson, D. A.; Raimi, O. G.; Blair, D. E.; Harrison, J. R.; Lockhart, D. E.; Torrie, L. S.; Ruda, G. F.; Wyatt, P. G.; Gilbert, I. H.; van Aalten, D. ACS Chem. Biol., <\/em>2015<\/strong>, 10<\/em>, 1425-1434.<\/p>\n","protected":false},"excerpt":{"rendered":"

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei. Cleghorn, L. A.; Albrecht, S.; Stojanovski, L.; Simeons, F. R.; Norval, S.; Kime, R.; Collie, I. T.; De Rycker, M.; Campbell, L.; Hallyburton, I.; Frearson, J. A.; Wyatt, P. G.; Read, K. D.; Gilbert, I. H. J Med Chem. 2015, 58, […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"full-width-page.php","meta":{"footnotes":""},"class_list":["post-1573","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages\/1573","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/comments?post=1573"}],"version-history":[{"count":9,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages\/1573\/revisions"}],"predecessor-version":[{"id":1615,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages\/1573\/revisions\/1615"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/media?parent=1573"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}