{"id":135,"date":"2013-09-05T19:46:08","date_gmt":"2013-09-05T19:46:08","guid":{"rendered":"http:\/\/blog.dundee.ac.uk\/ian-gilbert\/?page_id=135"},"modified":"2015-02-09T22:44:31","modified_gmt":"2015-02-09T22:44:31","slug":"ian-gilbert-research","status":"publish","type":"page","link":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/ian-gilbert-research\/","title":{"rendered":"Research"},"content":{"rendered":"<figure id=\"attachment_173\" aria-describedby=\"caption-attachment-173\" style=\"width: 300px\" class=\"wp-caption alignright\"><a href=\"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-content\/uploads\/sites\/4\/2013\/09\/parasite.png\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-173 \" title=\"A diagram of a trypanosome parasite\" src=\"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-content\/uploads\/sites\/4\/2013\/09\/parasite-300x221.png\" alt=\"A diagram of a trypanosome parasite\" width=\"300\" height=\"221\" srcset=\"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-content\/uploads\/sites\/4\/2013\/09\/parasite-300x221.png 300w, https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-content\/uploads\/sites\/4\/2013\/09\/parasite-150x110.png 150w, https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-content\/uploads\/sites\/4\/2013\/09\/parasite.png 798w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption id=\"caption-attachment-173\" class=\"wp-caption-text\">A diagram of a trypanosome parasite<\/figcaption><\/figure>\n<p>My background and research interests are in medicinal chemistry and I am based in Drug Discovery Unit (DDU), where I am the Head of Chemistry.<\/p>\n<p><strong>New Therapeutic Agents<\/strong><br \/>\nMy main research interests are in the design of potential new drug leads and potential therapeutic agents. In the Drug Discovery Unit (DDU), our focus is on neglected diseases and novel drug targets. We are tackling a number of neglected diseases such as the kinetoplastids, malaria, tuberculosis and animal trypanosomiasis. Our novel targets programme looks at new areas of biology that have not been tackled before from a drug discovery perspective, with the aim of de-risking them for further development. We have an integrated approach to drug discovery, including medicinal chemistry, hit discovery and cell biology, DMPK, computational chemistry and structural biology. We have developed a number of series from hits to full lead optimization programmes.<\/p>\n<p><strong>New Approaches to Drug Discovery<\/strong><br \/>\nThere is a very high rate of attrition within the drug discovery process, so I am interested in new approaches to drug discovery. Some examples of this work are:<br \/>\n\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0 Validation of new drug targets.<br \/>\n\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0 New computational approaches to drug discovery.<br \/>\n\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0 Developing new fragments for fragment-based drug discovery.<br \/>\n\u00b7\u00a0\u00a0\u00a0\u00a0\u00a0 Selective delivery of compounds to organisms.<\/p>\n<p><strong>Mode of Action Studies<\/strong><br \/>\nI am interested in understanding how compounds exert their pharmacological action. This is important, particularly for compounds derived from phenotypic screens. Knowing the target(s) of compounds is important in establishing and validating new biology, as well as adding to the drug discovery process. I am interested in applying chemistry to solve these problems, through techniques such as chemical proteomics.<\/p>\n<figure id=\"attachment_667\" aria-describedby=\"caption-attachment-667\" style=\"width: 700px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-667\" title=\"(i) malaria parasite, (ii) trypanosome parasites, (iii) mycobacterium tuberculosis bacteria\" src=\"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-content\/uploads\/sites\/4\/2013\/09\/parasites-1.png\" alt=\"malaria and trypanosome parasites and tb bacteria\" width=\"700\" height=\"200\" srcset=\"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-content\/uploads\/sites\/4\/2013\/09\/parasites-1.png 700w, https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-content\/uploads\/sites\/4\/2013\/09\/parasites-1-150x42.png 150w, https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-content\/uploads\/sites\/4\/2013\/09\/parasites-1-300x85.png 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><figcaption id=\"caption-attachment-667\" class=\"wp-caption-text\">(i) malaria parasite, (ii) trypanosome parasites, (iii) mycobacterium tuberculosis bacteria<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>My background and research interests are in medicinal chemistry and I am based in Drug Discovery Unit (DDU), where I am the Head of Chemistry. New Therapeutic Agents My main research interests are in the design of potential new drug leads and potential therapeutic agents. In the Drug Discovery Unit (DDU), our focus is on [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"full-width-page.php","meta":{"footnotes":""},"class_list":["post-135","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages\/135","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/comments?post=135"}],"version-history":[{"count":3,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages\/135\/revisions"}],"predecessor-version":[{"id":1189,"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/pages\/135\/revisions\/1189"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/ian-gilbert\/wp-json\/wp\/v2\/media?parent=135"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}