{"id":204,"date":"2023-10-12T11:16:53","date_gmt":"2023-10-12T10:16:53","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/david-horn\/?page_id=204"},"modified":"2026-04-29T17:04:24","modified_gmt":"2026-04-29T16:04:24","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.dundee.ac.uk\/david-horn\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Publications<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/orcid.org\/0000-0001-5173-9284\"><strong>ORCID<\/strong><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/scholar.google.co.uk\/citations?user=SeXXH18AAAAJ&amp;hl=en&amp;oi=ao\"><strong>Google Scholar<\/strong><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.scopus.com\/authid\/detail.uri?authorId=36145944800\"><strong>Scopus<\/strong><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.webofscience.com\/wos\/author\/record\/JHT-0993-2023\"><strong>Web of Science<\/strong><\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/discovery.dundee.ac.uk\/en\/persons\/david-horn\/\"><strong>University of Dundee Discovery Portal<\/strong><\/a><\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-blocksy-child-accordion\"><div class=\"accordion-controls\"><button class=\"accordion-open-all\" aria-expanded=\"false\">Open all <span class=\"visually-hidden\" aria-expanded=\"false\">sections<\/span><\/button><\/div>\n<div class=\"wp-block-blocksy-child-accordion-item\"><div class=\"accordion-header\"><button class=\"accordion-button\" aria-controls=\"content-accordion-90ac8f17-81c5-44d5-affa-4524bd452452\" id=\"button-accordion-90ac8f17-81c5-44d5-affa-4524bd452452\"><span class=\"accordion-title extra\">Selected research publications<\/span><\/button><\/div><div class=\"accordion-content\" id=\"content-accordion-90ac8f17-81c5-44d5-affa-4524bd452452\" aria-hidden=\"true\" aria-labelledby=\"button-accordion-90ac8f17-81c5-44d5-affa-4524bd452452\">\n<p><strong>Genetic origins and proteomic consequences of kinetoplast loss in trypanosomes.<\/strong>\u00a0Ridgway M, Escrivani DO, Novotn\u00e1 M, Wood A, \u00a0Tinti M, Schnaufer A, Horn D. <em>PLoS Pathogens.<\/em> 2026 Mar 25;22(3):e1013846.\u00a0doi: 10.1371\/journal.ppat.1013846. PMID <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41880374\/\">41880374<\/a>. <a href=\"https:\/\/journals.plos.org\/plospathogens\/article\/peerReview?id=10.1371\/journal.ppat.1013846\" data-type=\"link\" data-id=\"https:\/\/journals.plos.org\/plospathogens\/article\/peerReview?id=10.1371\/journal.ppat.1013846\">Peer Review file<\/a><\/p>\n\n\n\n<p><strong>Acoziborole resistance associated mutations in <em>Trypanosoma brucei<\/em> CPSF3.<\/strong>\u00a0Ridgway M, Novotn\u00e1 M, Mendoza Martinez C, Tinti M, Altmann S, Sloan G, Horn D. <em>PLoS Pathogens<\/em>. 2026 Mar 3;22(3):e1013764. doi: 10.1371\/journal.ppat.1013764. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41774758\/\">41774758<\/a>. <a href=\"https:\/\/journals.plos.org\/plospathogens\/article\/peerReview?id=10.1371\/journal.ppat.1013764\">Peer Review file<\/a>. Featured in <a href=\"https:\/\/communities.springernature.com\/posts\/predicting-drug-resistance-before-it-happens-integrating-genome-editing-structural-biology-and-computational-modelling\">Nature Portfolio Microbiology Community<\/a>.<\/p>\n\n\n\n<p><strong>Decoding efficacy and resistance space at a drug binding site.<\/strong>\u00a0Altmann S, Mendoza Martinez C, Ridgway M, Tinti M, Saini JS, Ibrahim PEGF, Thomas M, De Rycker M, Bodkin MJ, Horn D. (2026)\u00a0<em>Nat Commun<\/em>. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41639120\/\">41639120<\/a>. <a href=\"https:\/\/static-content.springer.com\/esm\/art%3A10.1038%2Fs41467-026-69187-5\/MediaObjects\/41467_2026_69187_MOESM2_ESM.pdf\">Peer Review file<\/a>. Featured in <a href=\"https:\/\/communities.springernature.com\/posts\/predicting-drug-resistance-before-it-happens-integrating-genome-editing-structural-biology-and-computational-modelling\">Nature Portfolio Microbiology Community<\/a>. <a href=\"https:\/\/www.dundee.ac.uk\/news\/decoding-drug-resistance-mutations-gene-editing\">FLS news<\/a>. <a href=\"https:\/\/www.linkedin.com\/feed\/update\/urn:li:activity:7429820861198675968\">LinkedIn<\/a>. <a href=\"https:\/\/www.youtube.com\/watch?v=52zoiwBNv0M\">Related video<\/a>.<\/p>\n\n\n\n<p><strong>A non-coding role for trypanosome\u00a0<em>VSG<\/em>\u00a0transcripts in allelic exclusion.<\/strong>\u00a0Escrivani DO, Hutchinson S, Tinti M, Wright JE, Marques CA, Faria JRC, Trenaman A, Horn D. (2025)\u00a0<em>Nucleic Acids Research<\/em>.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41118571\/\">53(19)<\/a>. <a href=\"https:\/\/www.dundee.ac.uk\/news\/rnas-compete-make-coat-parasitic-african-trypanosomes\">FLS news<\/a>.<\/p>\n\n\n\n<p><strong>Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes.<\/strong>&nbsp;Novotn\u00e1 M, Tinti M, Faria JRC, Horn, D. (2025)&nbsp;<em>Nature Communications<\/em>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40615444\/\">16:6194<\/a>.&nbsp;<a href=\"https:\/\/static-content.springer.com\/esm\/art%3A10.1038%2Fs41467-025-61480-z\/MediaObjects\/41467_2025_61480_MOESM2_ESM.pdf\">Peer Review file<\/a>. <a href=\"https:\/\/www.dundee.ac.uk\/news\/precision-editing-used-probe-unusual-gene-activity-controls-deadly-parasites\">FLS news<\/a>.<\/p>\n\n\n\n<p><strong>Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes.<\/strong>&nbsp;Trenaman A, Tinti M, Wall RJ, Horn D. (2024)&nbsp;<em>Nature Communications.<\/em>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39285175\/\">15:8113<\/a>.&nbsp;<a href=\"https:\/\/static-content.springer.com\/esm\/art%3A10.1038%2Fs41467-024-52432-0\/MediaObjects\/41467_2024_52432_MOESM2_ESM.pdf\">Peer Review file<\/a>. <a href=\"https:\/\/www.dundee.ac.uk\/news\/gene-expression-reprogramming-thousands-rna-sequences\">FLS news<\/a>.<\/p>\n\n\n\n<p><strong>An allele-selective inter-chromosomal protein bridge supports monogenic antigen expression in the African trypanosome.<\/strong>&nbsp;Faria JRC, Tinti M, Marques CA, Zoltner M, Yoshikawa H, Field MC, Horn D. (2023)&nbsp;<em>Nature Communications<\/em>.&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38081826\/\">14:8200<\/a>.&nbsp;<a href=\"https:\/\/static-content.springer.com\/esm\/art%3A10.1038%2Fs41467-023-44043-y\/MediaObjects\/41467_2023_44043_MOESM2_ESM.pdf\">Peer Review file<\/a>. Featured in&nbsp;<a href=\"https:\/\/communities.springernature.com\/posts\/all-for-one-and-one-for-all-united-we-stand-divided-we-fall-how-does-a-cell-express-only-one-gene-out-of-a-large-gene-family\">Nature Portfolio Microbiology Community<\/a>. <a href=\"https:\/\/www.dundee.ac.uk\/news\/gene-expression-control-bridge-between-two-chromosomes\">FLS news<\/a>.<\/p>\n\n\n\n<p><strong>Competition among variants is predictable and contributes to the antigenic variation dynamics of African trypanosomes.&nbsp;<\/strong>Escrivani DO, Scheidt V, Tinti M, Faria J, Horn D. (2023)&nbsp;<em>PLoS Pathog.&nbsp;<\/em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37459347\/\">19:e1011530<\/a>.&nbsp;<a href=\"https:\/\/journals.plos.org\/plospathogens\/article\/peerReview?id=10.1371\/journal.ppat.1011530\">Peer Review file<\/a>.<\/p>\n\n\n\n<p><strong>Genome-scale RNA interference profiling of&nbsp;<\/strong><em><strong>Trypanosoma brucei&nbsp;<\/strong><\/em><strong>cell cycle progression defects.&nbsp;<\/strong>Marques CA, Ridgway M, Tinti M, Cassidy A and Horn D&nbsp;(2022)&nbsp;<em>Nature Communications.&nbsp;<\/em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36088375\/\">13:5326<\/a>.&nbsp;<a href=\"https:\/\/static-content.springer.com\/esm\/art%3A10.1038%2Fs41467-022-33109-y\/MediaObjects\/41467_2022_33109_MOESM2_ESM.pdf\">Peer Review file<\/a>. <a href=\"https:\/\/www.dundee.ac.uk\/news\/parasite-division-cycles-decoded\">FLS news<\/a>.<\/p>\n\n\n\n<p><strong>Oligo targeting for profiling drug resistance mutations in the parasitic trypanosomatids.&nbsp;<\/strong>Altmann S, Rico E, Carvalho S, Ridgway M, Trenaman A, Donnelly H, Tinti M, Wyllie S and Horn D (2022)&nbsp;<em>Nucleic Acids Res.<\/em>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35524555\/\">50:e79<\/a>.&nbsp;<a href=\"https:\/\/www.youtube.com\/watch?v=52zoiwBNv0M\">Related video<\/a>. <a href=\"https:\/\/www.dundee.ac.uk\/news\/parasite-gene-editing-technology-profiling-drug-resistance-mutations\">FLS news<\/a>.<\/p>\n\n\n\n<p><strong>Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes.&nbsp;<\/strong>Faria J, Luzak V, M\u00fcller LSM, Brink BG, Hutchinson S, Glover L, Horn D, Siegel TN. (2021)&nbsp;<em>Nature Microbiology.<\/em>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33432154\/\">6:289-300<\/a>.&nbsp;<a href=\"https:\/\/static-content.springer.com\/esm\/art%3A10.1038%2Fs41564-020-00833-4\/MediaObjects\/41564_2020_833_MOESM2_ESM.pdf\">Peer Review file<\/a>. Featured in&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34588658\/\"><em>Nat Rev Microbiol<\/em>&nbsp;News &amp; Analysis<\/a>,&nbsp;<a href=\"https:\/\/www.nature.com\/articles\/s41564-021-01016-5.pdf\"><em>Nat Microbiol&nbsp;<\/em>editorial<\/a>,&nbsp;<a href=\"https:\/\/prelights.biologists.com\/highlights\/antigenic-variation-by-switching-inter-chromosomal-interactions-with-an-rna-splicing-locus-in-trypanosomes\/\">preLights<\/a>,&nbsp;<a href=\"https:\/\/microbiologycommunity.nature.com\/posts\/a-nuclear-enterprise-drives-immune-evasion\">Nature Portfolio Microbiology Community<\/a>. <a href=\"https:\/\/www.dundee.ac.uk\/press-release\/parasite-defence-mechanism-de-coded-dundee-research-team\">FLS news<\/a>.<\/p>\n\n\n\n<p><strong>Monoallelic expression and epigenetic inheritance sustained by a&nbsp;<\/strong><em><strong>Trypanosoma brucei&nbsp;<\/strong><\/em><strong>variant surface glycoprotein exclusion complex.&nbsp;<\/strong>Faria J, Glover L, Hutchinson S, Boehm C, Field MC, Horn D. (2019)&nbsp;<em>Nature Communications.&nbsp;<\/em><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31289266\">10:3023<\/a>.&nbsp;<a href=\"https:\/\/static-content.springer.com\/esm\/art%3A10.1038%2Fs41467-019-10823-8\/MediaObjects\/41467_2019_10823_MOESM2_ESM.pdf\">Peer Review file<\/a>.<\/p>\n\n\n\n<p><strong>A post-transcriptional respiratome regulon in trypanosomes.<\/strong>&nbsp;Trenaman A, Glover L, Hutchinson S, Horn D. (2019)<em>&nbsp;Nucleic Acids Res.<\/em>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31127277\/\">47:7063-7077<\/a>.<\/p>\n\n\n\n<p><strong>Gluconeogenesis using glycerol as a substrate in bloodstream-form&nbsp;<\/strong><em><strong>Trypanosoma brucei.<\/strong><\/em>&nbsp;Kov\u00e1\u0159ov\u00e1 J, Nagar R, Faria J, Ferguson MAJ, Barrett MP, Horn D.<em>&nbsp;<\/em>(2018)&nbsp;<em>PLoS Pathog<\/em>.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30589893\">14:e1007475&nbsp;<\/a><em>PLoS Pathogens<\/em>&nbsp;<a href=\"https:\/\/www.eurekalert.org\/news-releases\/488767\">Press Release<\/a>.<\/p>\n\n\n\n<p><strong>Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.&nbsp;<\/strong>Wall RJ, Rico E, Lukac I, Zuccotto F, Elg S, Gilbert IH, Freund Y, Alley MRK, Field MC, Wyllie S,&nbsp;Horn D. (2018)&nbsp;<em>Proc. Nat\u2019l Acad. Sci. USA<\/em>.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30185555\"><strong>115<\/strong>:9616-9621<\/a><\/p>\n\n\n\n<p><strong>Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes.<\/strong>&nbsp;Rico E, Kov\u00e1\u0159ov\u00e1 J, Jeacock L and Horn D. (2018)&nbsp;<em>Scientific Reports<\/em>.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29785042\"><strong>8<\/strong>:7960<\/a><\/p>\n\n\n\n<p><strong>Codon usage bias controls mRNA and protein abundance in trypanosomatids.<\/strong>&nbsp;Jeacock L, Faria J and Horn D. (2018)&nbsp;<em>eLife<\/em>.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29543155\"><strong>7<\/strong>:e32496<\/a>.&nbsp;<a href=\"https:\/\/elifesciences.org\/articles\/32496#SA2\">Peer Review file<\/a>. Featured in&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29910092\"><em>Trends in Parasitology<\/em><\/a>.<\/p>\n\n\n\n<p><strong>Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity.<\/strong>&nbsp;Jeacock L, Baker N, Wiedemar N, M\u00e4ser P and Horn D. (2017)&nbsp;<em>PLoS Pathogens<\/em>.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28358927\"><strong>13<\/strong>:e1006307<\/a><\/p>\n\n\n\n<p><strong>VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes.&nbsp;<\/strong>Glover L, Hutchinson S, Alsford&nbsp; S and Horn D. (2016)&nbsp;<em>Proc. Natl. Acad. Sci. USA<\/em>.&nbsp;&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27226299\"><strong>113<\/strong>:7225-30&nbsp;<\/a>Featured in&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27317742\"><em>Proc. Natl. Acad. Sci. USA Commentary<\/em><\/a>;&nbsp;<a href=\"http:\/\/www.drugdiscoverytoday.com\/view\/44284\/parasites-use-a-winner-takes-all-mechanism-to-evade-our-immune-defenses\/\">Drug Discovery Today<\/a>.<\/p>\n\n\n\n<p><strong>Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency and drug-sensitivity in trypanosomes.&nbsp;<\/strong>Baker N, Hamilton G, Wilkes J, Hutchinson S, Barrett MP, Horn D. (2015)&nbsp;&nbsp;<em>Proc. Natl. Acad. Sci. USA<\/em>.&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26150481\"><strong>112<\/strong>:9112-9117<\/a><\/p>\n\n\n\n<p><strong>Cathepsin-L can resist lysis by human serum in&nbsp;<\/strong><em><strong>Trypanosoma brucei brucei.<\/strong><\/em><strong>&nbsp;<\/strong>Alsford S, Currier RB, Guerra-Assun\u00e7\u00e3o JA, Clark TG, Horn D (2014)&nbsp;<em>PLoS Pathogens<\/em>.&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24830321\"><strong>10<\/strong>:e1004130<\/a><\/p>\n\n\n\n<p><strong>Locus-specific control of DNA resection and suppression of subtelomeric&nbsp;<\/strong><em><strong>VSG<\/strong><\/em><strong>&nbsp;recombination by HAT3 in the African trypanosome.&nbsp;<\/strong>Glover L, Horn D<em>&nbsp;<\/em>(2014)&nbsp;<em>Nucleic Acids Res.&nbsp;<\/em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25300492\"><strong>42<\/strong>:12600-12613<\/a><\/p>\n\n\n\n<p><strong>DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes. &nbsp;<\/strong>Glover L, Alsford S and Horn D (2013)&nbsp;<em>PLoS Pathogens&nbsp;<\/em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23555264\"><strong>9:<\/strong>e1003260<\/a><\/p>\n\n\n\n<p><strong>Cell cycle regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in&nbsp;<\/strong><em><strong>Trypanosoma brucei<\/strong><\/em><strong>. &nbsp;<\/strong>Alsford S and Horn D (2012)&nbsp;<em>Nucleic Acids Res.&nbsp;<\/em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22941664\"><strong>40<\/strong>:10150-60<\/a><\/p>\n\n\n\n<p><strong>Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes.&nbsp;<\/strong>Baker N, Glover L, Munday JC, Aguinaga Andr\u00e9s D, Barrett MP, de Koning HP and Horn D (2012)&nbsp;<em>Proc. Natl. Acad. Sci. USA&nbsp;<\/em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22711816\"><strong>109<\/strong>:10996\u201311001&nbsp;<\/a>Featured in :&nbsp;<a href=\"http:\/\/www.lshtm.ac.uk\/newsevents\/news\/2012\/gene_clue_to_drug_resistance_in_sleeping_sickness.html\">LSHTM news<\/a>;&nbsp;<a href=\"http:\/\/apps.who.int\/iris\/bitstream\/10665\/95732\/1\/9789241209847_eng.pdf\">WHO policy document<\/a>;&nbsp;<a href=\"https:\/\/youtu.be\/awCMdqmuZbQ\">Dundee student video<\/a>.<\/p>\n\n\n\n<p><strong>High-throughput decoding of antitrypanosomal drug efficacy and resistance.&nbsp;<\/strong>Alsford S, Eckert S, Baker N, Glover L, Sanchez-Flores A, Leung K, Turner DJ, Field MC, Berriman M and Horn D. (2012)&nbsp;<em>Nature&nbsp;<\/em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22278056\"><strong>482<\/strong>:232-236<\/a>&nbsp;<a href=\"http:\/\/europepmc.org\/articles\/PMC3303116\">PMC&nbsp;<\/a>Featured in:&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22318598\"><em>Nature<\/em>&nbsp;News &amp; Views<\/a>,&nbsp;<a href=\"http:\/\/www.newscientist.com\/article\/dn21393-sleeping-sickness-tests-may-identify-better-therapies.html\"><em>New Scientist<\/em><\/a><em>,&nbsp;<\/em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22943541\"><em>Pathogens &amp; Global Health<\/em><\/a><em>,&nbsp;<\/em><a href=\"https:\/\/www.lshtm.ac.uk\/newsevents\/news\/2012\/genetic_screens_bring_new_hope_for_tackling_sleeping_sickness.html\">LSHTM news<\/a>,&nbsp;<a href=\"http:\/\/apps.who.int\/iris\/bitstream\/10665\/95732\/1\/9789241209847_eng.pdf\">WHO policy document<\/a>,&nbsp;<a href=\"http:\/\/www.lifesci.dundee.ac.uk\/groups\/david-horn\/past-news-items\">Other media<\/a>.<\/p>\n\n\n\n<p><strong>Elongator protein 3b negatively regulates ribosomal DNA transcription in African trypanosomes. &nbsp;<\/strong>Alsford S and Horn D. (2011)&nbsp;<em>Mol Cell Biol&nbsp;<\/em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21357738\"><strong>31<\/strong>:1822-1832<\/a><\/p>\n\n\n\n<p><strong>Microhomology mediated deletion and gene conversion in African trypanosomes. &nbsp;<\/strong>Glover L, Jun J and Horn D. (2011)&nbsp;<em>Nucleic Acids Res.&nbsp;<\/em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20965968\"><strong>39<\/strong>:1372-1380<\/a><\/p>\n\n\n\n<p><strong>High throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome.&nbsp;<\/strong>Alsford S, Turner DJ., Obado SO, Sanchez-Flores A, Glover L, Berriman M, Hertz-Fowler C and Horn D. (2011)&nbsp;<em>Genome Research&nbsp;<\/em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21363968\"><strong>21<\/strong>:915-924&nbsp;<\/a>Featured in:&nbsp;<a href=\"http:\/\/www.nature.com\/nbt\/journal\/v29\/n4\/pdf\/nbt.1853.pdf\"><em>Nature Biotechnology<\/em><\/a><em>,&nbsp;<\/em><a href=\"http:\/\/www.nature.com\/nmeth\/journal\/v8\/n5\/pdf\/nmeth0511-370b.pdf\"><em>Nature Methods,<\/em><\/a><em>&nbsp;<\/em><a href=\"http:\/\/www.nature.com\/nrmicro\/journal\/v9\/n6\/pdf\/nrmicro2583.pdf\"><em>Nature Reviews Microbiology<\/em><\/a>. Data hosted by:&nbsp;<a href=\"http:\/\/tritrypdb.org\/tritrypdb\/\">Tritryp Database<\/a>,&nbsp;<a href=\"http:\/\/tdrtargets.org\/\">TDR Targets Database<\/a>,&nbsp;<a href=\"http:\/\/www.bi.cs.titech.ac.jp\/introdb\/\">iNTRODB<\/a>.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-blocksy-child-accordion-item\"><div class=\"accordion-header\"><button class=\"accordion-button\" aria-controls=\"content-accordion-c6eeb6f3-4fbf-450a-9691-6eed4858f5ec\" id=\"button-accordion-c6eeb6f3-4fbf-450a-9691-6eed4858f5ec\"><span class=\"accordion-title extra\">Selected research collaborations<\/span><\/button><\/div><div class=\"accordion-content\" id=\"content-accordion-c6eeb6f3-4fbf-450a-9691-6eed4858f5ec\" aria-hidden=\"true\" aria-labelledby=\"button-accordion-c6eeb6f3-4fbf-450a-9691-6eed4858f5ec\">\n<p><strong>FMOPhore for hotspot identification and efficient fragment-to-lead growth strategies.<\/strong>\u00a0Ibrahim PEGF, Altmann S, Zachariae U, Horn D, Gilbert IH, Bodkin MJ. <em>Nat Commun. <\/em>2026 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42045222\/\">Apr 28<\/a>.<\/p>\n\n\n\n<p><strong>Identification of a proteasome-targeting arylsulfonamide with potential for the treatment of Chagas\u2019 disease.\u00a0<\/strong>Lima M, Tulloch L, Corpas Lopez V, Carvalho S, Wall R, Milne R, Rico E, Patterson S, Gilbert I, Moniz S, MacLean L, Torrie L, Morgillo C, Horn D, Zuccotto F, Wyllie S.\u00a0(2022) <em>Antimicrob. Agents Chemother.<\/em>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34606338\/\" data-type=\"link\" data-id=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34606338\/\">66:e0153521<\/a>.<\/p>\n\n\n\n<p><strong>Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs.<\/strong>\u00a0Giordani F, Paape D, Vincent IM, Pountain AW, Fernandez-Cortes F, Rico E, Zhang N, Morrison LJ, Freund Y, Witty MJ, Peter R, Edwards DY, Wilkes J, Van der Hooft J, Regnault C, Read KD, Horn D, Field MC, Barrett MP. (2020)\u00a0<em>PLoS Pathogens.<\/em>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33141865\/\">e1008932<\/a>.\u00a0<a href=\"https:\/\/journals.plos.org\/plospathogens\/article\/peerReview?id=10.1371\/journal.ppat.1008932\">Peer Review file<\/a>.<\/p>\n\n\n\n<p><strong>Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.&nbsp;<\/strong>Wyllie S, Brand S, Thomas M, De Rycker M, Chung CW, Pena I, Bingham RP, Bueren-Calabuig JA, Cantizani J, Cebrian D, Craggs PD, Ferguson L, Goswami P, Hobrath J, Howe J, Jeacock L, Ko EJ, Korczynska J, MacLean L, Manthri S, Martinez MS, Mata-Cantero L, Moniz S, N\u00fchs A, Osuna-Cabello M, Pinto E, Riley J, Robinson S, Rowland P, Simeons FRC, Shishikura Y, Spinks D, Stojanovski L, Thomas J, Thompson S, Viayna Gaza E, Wall RJ, Zuccotto F, Horn D, Ferguson MAJ, Fairlamb AH, Fiandor JM, Martin J, Gray DW, Miles TJ, Gilbert IH, Read KD, Marco M, Wyatt PG. (2019)&nbsp;<em>Proc Natl Acad Sci U S A.<\/em>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30962368\/\"><strong>116<\/strong>:9318-9323.&nbsp;<\/a>See&nbsp;<a href=\"https:\/\/www.youtube.com\/watch?v=eJyuzo-AGH8\">Wellcome Trust video<\/a>.<\/p>\n\n\n\n<p><strong>Chemogenomic profiling of anti-leishmanial efficacy and resistance in the related kinetoplastid parasite&nbsp;<\/strong><em><strong>Trypanosoma brucei<\/strong><\/em><strong>.&nbsp;<\/strong>Collett CF, Kitson C, Baker N, Steele-Stallard HB, Santrot MV, Hutchinson S, Horn D, Alsford S. (2019)&nbsp;<em>Antimicrob Agents Chemother.<\/em>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31160283\/\">e00795-19<\/a>.<\/p>\n\n\n\n<p><strong>Antitrypanosomal 8-hydroxy-naphthyridines are chelators of divalent transition metals.&nbsp;<\/strong>Wall RJ, Moniz S, Thomas MG, Norval S, Ko EJ, Marco M, Miles TJ, Gilbert IH, Horn D, Fairlamb AH, Wyllie S. (2018)&nbsp;<em>Antimicrob Agents Chemother.<\/em>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29844044\/\">e00235-18<\/a>. GlaxoSmithKline Scientific Termination of Projects&nbsp;<a href=\"https:\/\/wcair.dundee.ac.uk\/scientists-praised-for-pulling-plug-on-a-drug\/\">(STOP) Award 2017<\/a><\/p>\n\n\n\n<p><strong>Host-Parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.<\/strong>&nbsp;Zhang N, Zoltner M, Leung K-F, Scullion P, Hutchinson S, del Pino RC, Vincent IM, Zhang Y-K, Freund YR, Alley MRK, Jacobs RT, Read KD, Barrett MP, Horn D and Field MC. (2018)<em>&nbsp;PLoS Pathogens<\/em>.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29425238\">14:e1006850<\/a>.<\/p>\n\n\n\n<p><strong>Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs.&nbsp;<\/strong>Meredith EL, Kumar A, Konno A, Szular J, Alsford S, Seifert K, Horn D and Wilkinson SR. (2017)&nbsp;<em>Mol. Microbiol.<\/em>&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28792090\"><strong>106<\/strong>:207-222.&nbsp;<\/a>Featured in&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28833608\"><em>Mol. Microbiol.&nbsp;<\/em>MicroCommentary<\/a><\/p>\n\n\n\n<p><strong>Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in&nbsp;<\/strong><em><strong>Trypanosoma brucei.<\/strong><\/em>&nbsp;Stortz JA, Serafim TD, Alsford S, Wilkes J, Fernandes-Cortes F, Hamilton G, Briggs E, Lemgruber L, Horn D, Mottram JC and McCulloch R. (2017)&nbsp;<em>PLoS Pathogens<\/em>.<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28742144\"><strong>13<\/strong>:e1006477<\/a><\/p>\n\n\n\n<p><strong>Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in&nbsp;<\/strong><em><strong>Trypanosoma brucei.<\/strong><\/em>&nbsp;Rico E, Ivens A, Glover L, Horn D and Matthews K. (2017)&nbsp;<em>PLoS Pathogens.<\/em>&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28334017\"><strong>13<\/strong>:e1006279<\/a><\/p>\n\n\n\n<p><strong>The role of folate transport in antifolate drug action in&nbsp;<\/strong><em><strong>Trypanosoma brucei.&nbsp;<\/strong><\/em>Dewar S, Sienkiewicz N, Ong HB, Wall RJ, Horn D and Fairlamb AH. (2016)&nbsp;<em>J. Biol. Chem.<\/em>&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27703008\"><strong>291<\/strong>:24768\u201324778<\/a><\/p>\n\n\n\n<p><strong>Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression.&nbsp;<\/strong>Maishman L, Obado SO, Alsford S, Bart J, Chen W, Ratushny AV, Navarro M, Horn D, Aitchison JD, Chait BT, Rout MP and Field MC. (2016)&nbsp;<em>Nucleic Acids Res<\/em>.&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27625397\"><strong>44<\/strong>:10554-10570<\/a><\/p>\n\n\n\n<p><strong>Pentamidine is not a permeant but a nanomolar inhibitor of the&nbsp;<\/strong><em><strong>Trypanosoma brucei<\/strong><\/em><strong>&nbsp;aquaglyceroporin-2.&nbsp;<\/strong>Song J, Baker N, Rothert M, Henke B, Jeacock L, Horn D, Beitz E. (2016)&nbsp;<em>PLoS Pathogens<\/em>.&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26828608\"><strong>12<\/strong>:e1005436<\/a><\/p>\n\n\n\n<p><strong>Modulation of the surface proteome through multiple ubiquitylation pathways in African trypanosomes.&nbsp;<\/strong>Zoltner M, Leung K-F, Alsford S, Horn D and Field MC. (2015)&nbsp;<em>PLoS Pathogens<\/em>.&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26492041\"><strong>11<\/strong>:e1005236<\/a><\/p>\n\n\n\n<p><strong>Chimerization at the&nbsp;<\/strong><em><strong>AQP2-AQP3<\/strong><\/em><strong>&nbsp;locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical&nbsp;<\/strong><em><strong>Trypanosoma brucei gambiense<\/strong><\/em><strong>&nbsp;isolates.&nbsp;<\/strong>Graf FE, Baker N, Munday JC, de Koning HP, Horn D, M\u00e4ser P.<em>&nbsp;<\/em>(2015)&nbsp;<em>Int.<\/em>&nbsp;<em>J. Parasitol; Drugs &amp; Drug Resistance&nbsp;<\/em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26042196\"><strong>5<\/strong>:65-68<\/a><\/p>\n\n\n\n<p><strong>Genome wide dissection of the quorum sensing signaling pathway in&nbsp;<\/strong><em><strong>Trypanosoma brucei.<\/strong><\/em><strong>&nbsp;<\/strong>Mony BM, MacGregor P, Ivens A, Rojas F, Cowton A, Wilson J, Horn D and Matthews KR (2014)&nbsp;<em>Nature.&nbsp;<\/em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24336212\"><strong>505:<\/strong>681-685<\/a><\/p>\n\n\n\n<p><strong>Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNAi library screening for resistance to the phosphodiesterase inhibitor Cpd A.&nbsp;<\/strong>Gould MK, Bachmaier S, Ali JA, Alsford S, Tagoe DN, Munday JC, Schnaufer AC, Horn D, Boshart M and de Koning HP (2013)&nbsp;<em>Antimicrob. Agents Chemother.&nbsp;<\/em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23877697\"><strong>57:<\/strong>4882-93<\/a><\/p>\n\n\n\n<p><strong>PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome.&nbsp;<\/strong>Rudd SG, Glover L, Jozwiakowski SK, Horn D and Doherty AJ (2013)&nbsp;<em>Mol. Cell&nbsp;<\/em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24267450\"><strong>52:<\/strong>554-565.&nbsp;<\/a>See&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24304914\"><em>Nature Struct. &amp; Mol. Biol.&nbsp;<\/em>News &amp; Views<\/a>.<\/p>\n\n\n\n<p><strong>NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions.&nbsp;<\/strong>duBois K, Alsford S, Buisson J, Swiderski M, Bart J, Bastin P, Barry D, Navarro M, Horn D, Aitchison J, Rout M and Field M. (2012)&nbsp;<em>PLOS Biology&nbsp;<\/em><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22479148\"><strong>10<\/strong>:e1001287<\/a><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-blocksy-child-accordion-item\"><div class=\"accordion-header\"><button class=\"accordion-button\" aria-controls=\"content-accordion-804c54e2-9307-4eff-ad23-f6e72ad934fe\" id=\"button-accordion-804c54e2-9307-4eff-ad23-f6e72ad934fe\"><span class=\"accordion-title extra\">Selected reviews<\/span><\/button><\/div><div class=\"accordion-content\" id=\"content-accordion-804c54e2-9307-4eff-ad23-f6e72ad934fe\" aria-hidden=\"true\" aria-labelledby=\"button-accordion-804c54e2-9307-4eff-ad23-f6e72ad934fe\">\n<p><strong>Pass the boron: benzoxaboroles as antiparasite drugs.<\/strong>\u00a0Zoltner M, Horn D, Field MC.\u00a0(2024) <em>Trends Parasitol.<\/em>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39107181\/\" data-type=\"link\" data-id=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39107181\/\">40:820-828<\/a>.<\/p>\n\n\n\n<p><strong>Anti-trypanosomatid drug discovery: progress and challenges.\u00a0<\/strong>De Rycker M, Wyllie S, Horn D, Read KD, Gilbert IH.\u00a0(2023)\u00a0<em>Nature Reviews Microbiology.\u00a0<\/em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35995950\/\"><strong>21<\/strong>;35-50<\/a>.<\/p>\n\n\n\n<p><strong>A profile of research on the parasitic trypanosomatids and the diseases they cause.&nbsp;<\/strong>Horn D. (2022)&nbsp;<em>PLoS Negl Trop Dis.&nbsp;<\/em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35025891\/\"><strong>16<\/strong>:e0010040<\/a><\/p>\n\n\n\n<p><strong>Genome-scale RNAi screens in African trypanosomes&nbsp;<\/strong>Horn D.&nbsp;(2022)&nbsp;<em>Trends Parasitol.&nbsp;<\/em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34580035\/\"><strong>38<\/strong>:160-173&nbsp;<\/a>Featured in&nbsp;<a href=\"https:\/\/www.cell.com\/cp\/collections-world-neglected-tropical-diseases-day-2022\">Cell Press special collection<\/a>&nbsp;for World NTDs Day 2022<\/p>\n\n\n\n<p><strong>Melarsoprol resistance in African trypanosomiasis.<\/strong>&nbsp;Fairlamb, A and Horn, D. (2018)&nbsp;<em>Trends in Parasitology<\/em>.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29705579\"><strong>34<\/strong>:481-492<\/a><\/p>\n\n\n\n<p><strong>Anti-trypanosomatid drug discovery: An ongoing challenge and a continuing need.&nbsp;<\/strong>Field MC, Horn D, Fairlamb AH, Ferguson MAJ, Gray DW, Read KD, De Rycker M, Torrie LS, Wyatt PG, Wyllie S and Gilbert IH. (2017)&nbsp;<em>Nature Reviews Microbiol.<\/em>&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28239154\"><strong>15<\/strong>:217-231<\/a><\/p>\n\n\n\n<p><strong>Research Matters: How antiparasitic drugs work \u2013 and sometimes stop working! *&nbsp;<\/strong>Horn D. (2016)&nbsp;<em>PLoS Pathogens<\/em>.&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27149375\"><strong>12<\/strong>:e1005430<\/a><\/p>\n\n\n\n<p><strong>Protocol: Genome-scale RNAi screens for high-throughput phenotyping in bloodstream form African trypanosomes.&nbsp;<\/strong>Glover L, Alsford S, Baker N, Turner DJ, Sanchez-Flores A, Hutchinson S, Hertz-Fowler C, Berriman M and Horn D (2015)&nbsp;<em>Nature Protocols<\/em>.&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25502887\"><strong>10<\/strong>:106\u2013133<\/a><\/p>\n\n\n\n<p><strong>Antigenic variation in African trypanosomes.&nbsp;<\/strong>Horn D. (2014)&nbsp;<em>Mol. Biochem. Parasitol.<\/em>&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24859277\"><strong>195<\/strong>:123-129<\/a><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-blocksy-child-accordion-item\"><div class=\"accordion-header\"><button class=\"accordion-button\" aria-controls=\"content-accordion-bb61b9c0-f6c8-4b85-b0b8-8793fe575b44\" id=\"button-accordion-bb61b9c0-f6c8-4b85-b0b8-8793fe575b44\"><span class=\"accordion-title extra\">Full publications list<\/span><\/button><\/div><div class=\"accordion-content\" id=\"content-accordion-bb61b9c0-f6c8-4b85-b0b8-8793fe575b44\" aria-hidden=\"true\" aria-labelledby=\"button-accordion-bb61b9c0-f6c8-4b85-b0b8-8793fe575b44\">\n<h4 class=\"wp-block-heading\"><strong>2026 &#8211; preprints under review<\/strong><\/h4>\n\n\n\n<p><strong>ZNK1 senses zinc and degrades zinc transporter mRNA in trypanosomes.&nbsp;<\/strong>Teresa Leao, Anna Trenaman, Michele Tinti, Gustavo Bravo Ruiz, Idalio Viegas, Luisa M Figueiredo, Margarida Duarte, Ana Tomas, David Horn. https:\/\/doi.org\/10.64898\/2026.01.27.702079&nbsp;<a href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.01.27.702079\"><em>BioRxiv<\/em><\/a><\/p>\n\n\n\n<p><strong>Thermo-sensing and argonaute-dependent transcriptome remodelling in trypanosomes.<\/strong>&nbsp;Gustavo Bravo Ruiz,&nbsp; Michele Tinti,&nbsp; David Horn. https:\/\/doi.org\/10.64898\/2026.01.20.700697&nbsp;<a href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.01.20.700697v1\"><em>BioRxiv<\/em><\/a><\/p>\n\n\n\n<p><strong>A Genome-Wide Genetic Screen Identifies a Novel kDNA Replication Protein in Trypanosomes.<\/strong>&nbsp;Migla Miskinyte, Clirim Jetishi, Ana Kalichava, Alasdair Ivens, Martin Waterfall, Matt Gould, Lucy Glover, David Horn, Torsten Ochsenreiter, Achim Schnaufer. https:\/\/doi.org\/10.64898\/2026.01.05.697628&nbsp;<a href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.01.05.697628v1\"><em>BioRxiv<\/em><\/a><\/p>\n\n\n\n<p><strong>Targeted protein degradation of the CPSF complex by benzoxaboroles through sumoylation.<\/strong>&nbsp;Ning Zhang, Abdul Samad, Farnaz Zahedifard, Richard J. Wall, David Horn, Martin Zoltner, &nbsp;Mark C. Field. doi: https:\/\/doi.org\/10.1101\/2024.03.11.584402&nbsp;<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.03.11.584402v1\"><em>BioRxiv<\/em><\/a><\/p>\n\n\n\n<p><strong>2026<\/strong><\/p>\n\n\n\n<p><strong>FMOPhore for hotspot identification and efficient fragment-to-lead growth strategies.<\/strong>\u00a0Ibrahim PEGF, Altmann S, Zachariae U, Horn D, Gilbert IH, Bodkin MJ. <em>Nat Commun. <\/em>2026 Apr 28.\u00a0doi: 10.1038\/s41467-026-72384-x. PMID <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42045222\/\">42045222<\/a> Free article<\/p>\n\n\n\n<p><strong>Genetic origins and proteomic consequences of kinetoplast loss in trypanosomes.<\/strong>\u00a0Ridgway M, Escrivani DO, Novotn\u00e1 M, Wood A, \u00a0Tinti M, Schnaufer A, Horn D. <em>PLoS Pathogens.<\/em> 2026 Mar 25;22(3):e1013846.\u00a0doi: 10.1371\/journal.ppat.1013846. PMID <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41880374\/\">41880374<\/a> Free article<\/p>\n\n\n\n<p><strong>Acoziborole resistance associated mutations in <em>Trypanosoma brucei<\/em> CPSF3.<\/strong>\u00a0Ridgway M, Novotn\u00e1 M, Mendoza Martinez C, Tinti M, Altmann S, Sloan G, Horn D. <em>PLoS Pathogens<\/em>. 2026 Mar 3;22(3):e1013764. doi: 10.1371\/journal.ppat.1013764. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41774758\/\">41774758<\/a> Free article<\/p>\n\n\n\n<p><strong>Decoding efficacy and resistance space at a drug binding site.<\/strong>\u00a0Altmann S, Mendoza Martinez C, Ridgway M, Tinti M, Saini JS, Ibrahim PEGF, Thomas M, De Rycker M, Bodkin MJ, Horn D.\u00a0<em>Nat Commun<\/em>. 2026. doi: 10.1038\/s41467-026-69187-5. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41639120\/\">41639120<\/a> Free article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2025<\/strong><\/h4>\n\n\n\n<p><strong>A non-coding role for trypanosome\u00a0<em>VSG<\/em>\u00a0transcripts in allelic exclusion.<\/strong>\u00a0Escrivani DO, Hutchinson S, Tinti M, Wright JE, Marques CA, Faria JRC, Trenaman A, Horn D.\u00a0<em>Nucleic Acids Research<\/em>.\u00a02025 Oct 14;53(19):\u00a0doi: 10.1093\/nar\/gkaf1011.\u00a0PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41118571\/\">41118571<\/a>\u00a0Free article<\/p>\n\n\n\n<p><strong>Decoding post-transcriptional gene expression controls in trypanosomatids using machine learning.<\/strong>&nbsp;Tinti M and Horn D.&nbsp;<em>Wellcome Open Res<\/em>.&nbsp;2025,&nbsp;<strong>10<\/strong>:173.&nbsp;https:\/\/wellcomeopenresearch.org\/articles\/10-173. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40735494\/\">40735494<\/a>&nbsp;Free article<\/p>\n\n\n\n<p><strong>Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes.<\/strong>\u00a0 Novotn\u00e1 M, Tinti M, Faria JRC, Horn D.\u00a0<em>Nat Commun.<\/em>\u00a02025 Jul 4;16(1):6194.\u00a0doi: 10.1038\/s41467-025-61480-z.\u00a0PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40615444\/\">40615444<\/a>\u00a0Free article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2024<\/strong><\/h4>\n\n\n\n<p><strong>Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes.<\/strong>&nbsp;Trenaman A, Tinti M, Wall RJ, Horn D.&nbsp;<em>Nat Commun.<\/em>&nbsp;2024 Sep 16;15(1):8113. doi: 10.1038\/s41467-024-52432-0. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39285175\/\">39285175<\/a>&nbsp;Free article.<\/p>\n\n\n\n<p><strong>Pass the boron: benzoxaboroles as antiparasite drugs.<\/strong>&nbsp;Zoltner M, Horn D, Field MC.&nbsp;<em>Trends Parasitol.<\/em>&nbsp;2024 Sep;40(9):820-828. doi: 10.1016\/j.pt.2024.07.003. Epub 2024 Aug 5. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39107181\/\">39107181<\/a>&nbsp;Free article<\/p>\n\n\n\n<p><strong>The bloodstream form of&nbsp;<em>Trypanosoma brucei<\/em>&nbsp;displays non-canonical gluconeogenesis<\/strong><strong>.&nbsp;<\/strong>Kov\u00e1\u0159ov\u00e1 J, Moos M, Barrett MP, Horn D, Z\u00edkov\u00e1 A.&nbsp;<em>PLoS Negl Trop Dis.<\/em>&nbsp;2024 Feb 23;18(2):e0012007. doi: 10.1371\/journal.pntd.0012007. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38394337\/\">38394337<\/a>&nbsp;Free PMC article.<\/p>\n\n\n\n<p><strong>Genome-wide screens connect HD82 loss-of-function to purine analog resistance in African trypanosomes.<\/strong>&nbsp;Trenaman A, Tinti M, Atrih A, Horn D.&nbsp;<em>mSphere<\/em>. 2023 Dec 21:e0036323.&nbsp; doi: 10.1128\/msphere.00363-23. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38126788\/\">38126788<\/a>&nbsp;Free PMC article.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2023<\/strong><\/h4>\n\n\n\n<p><strong>An allele-selective inter-chromosomal protein bridge supports monogenic antigen expression in the African trypanosome.<\/strong>&nbsp;Faria JRC, Tinti M, Marques CA, Zoltner M, Yoshikawa H, Field MC, Horn D.&nbsp;<em>Nature Communications<\/em>. 2023 Dec 11;14(1):8200.&nbsp; doi: 10.1038\/s41467-023-44043-y. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38081826\/\">38081826<\/a>&nbsp;Free PMC article.<\/p>\n\n\n\n<p><strong>Competition among variants is predictable and contributes to the antigenic variation dynamics of African trypanosomes.<\/strong>&nbsp;Escrivani DO, Scheidt V, Tinti M, Faria J, Horn D.&nbsp;<em>PLoS Pathog.<\/em>&nbsp;2023 Jul 17;19(7):e1011530. doi: 10.1371\/journal.ppat.1011530. eCollection 2023 Jul. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37459347\/\">37459347<\/a>&nbsp;Free PMC article.<\/p>\n\n\n\n<p><strong>Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Bachmaier S, Gould MK, Polatoglou E, Omelianczyk R, Brennand AE, Aloraini MA, Munday JC, Horn D, Boshart M, de Koning HP.&nbsp;<em>Front Cell Infect Microbiol.<\/em>&nbsp;2023 Jul 5;13:1204707. doi: 10.3389\/fcimb.2023.1204707. eCollection 2023. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37475965\/\">37475965<\/a>&nbsp;Free PMC article.<\/p>\n\n\n\n<p><strong>Anti-trypanosomatid drug discovery: progress and challenges.<\/strong>&nbsp;de Rycker M, Wyllie S, Horn D, Read KD, Gilbert IH.&nbsp;<em>Nature Reviews Microbiology.&nbsp;<\/em>2023 Jan 21(1):35-50. &nbsp;doi: 10.1038\/s41579-022-00777-y. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35995950\/\">35995950<\/a>&nbsp;&nbsp;Free PMC article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2022<\/strong><\/h4>\n\n\n\n<p><strong>Genome-scale RNA interference profiling of&nbsp;<em>Trypanosoma brucei<\/em>&nbsp;cell cycle progression defects.&nbsp;<\/strong>Marques CA, Ridgway M, Tinti M, Cassidy A and Horn D.&nbsp;<em>Nature Communications.&nbsp;<\/em>2022 Sep 10;13(1):5326. doi: 10.1038\/s41467-022-33109-y. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36088375\/\">36088375<\/a>&nbsp;&nbsp;Free PMC article<\/p>\n\n\n\n<p><strong>Oligo targeting for profiling drug resistance mutations in the parasitic trypanosomatids.&nbsp;<\/strong>Altmann S, Rico E, Carvalho S, Ridgway M, Trenaman A, Donnelly H, Tinti M, Wyllie S, Horn D.&nbsp;<em>Nucleic Acids Res<\/em>. 2022 Aug 12;50(14):e79. &nbsp;doi: 10.1093\/nar\/gkac319. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35524555\/\">35524555<\/a>&nbsp;Free PMC article<\/p>\n\n\n\n<p><strong>Repositioning of a diaminothiazole series confirmed to target the cyclin-dependent kinase CRK12 for use in the treatment of African animal trypanosomiasis.&nbsp;<\/strong>Smith A, Wall RJ, Patterson S, Rowan T, Rico E, Stojanovski L, Huggett M, Hampton SE, Thomas MG, Corpas-Lopez V, Gillingwater K, Duke J, Napier G, Peter R, Vitouley HS, Harrison JR, Milne R, Jeacock L, Baker N, Davis SH, Simeons F, Riley J, Horn D, Brun R, Zuccotto F, Witty MJ, Wyllie S, Read KD, Gilbert IH.&nbsp;<em>J. Med. Chem.<\/em>&nbsp;2022&nbsp;Apr 14;65(7):5606-5624. &nbsp;doi: 10.1021\/acs.jmedchem.1c02104. Epub 2022 Mar 18. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35303411\/\">35303411<\/a>&nbsp;Free PMC article<\/p>\n\n\n\n<p><strong>CRISPR\/Cas9-based precision tagging of essential genes in bloodstream form African trypanosomes.&nbsp;<\/strong>Kov\u00e1\u0159ov\u00e1 J, Novotn\u00e1 M, Faria J, Rico E, Wallace C, Zoltner M, Field MC, Horn D.&nbsp;<em>Molecular &amp; Biochemical Parasitology<\/em>. 2022 May;249:111476. &nbsp;doi: 10.1016\/j.molbiopara.2022.111476. Epub 2022 Apr 1. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35378143\/\">35378143<\/a>&nbsp;Free article<\/p>\n\n\n\n<p><strong>Control of variant surface glycoprotein expression by CFB2 in&nbsp;<em>Trypanosoma brucei<\/em>&nbsp;and quantitative proteomic connections to translation and cytokinesis.&nbsp;<\/strong>Bravo Ruiz G, Tinti M, Ridgway M, Horn D.&nbsp;<em>mSphere<\/em>. 2022 Apr 27;7(2):e0006922. &nbsp;doi: 10.1128\/msphere.00069-22. &nbsp;Epub 2022 Mar 21. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35306877\/\">35306877<\/a>&nbsp;Free article<\/p>\n\n\n\n<p><strong>A profile of research on the parasitic trypanosomatids and the diseases they cause.&nbsp;<\/strong>Horn D.&nbsp;<em>PLoS Negl Trop Dis.<\/em>&nbsp;2022 Jan 13;16(1):e0010040. doi: 10.1371\/journal.pntd.0010040. eCollection 2022 Jan. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35025891\/\">35025891<\/a>&nbsp;Free PMC article<\/p>\n\n\n\n<p><strong>Identification of a proteasome-targeting arylsulfonamide with potential for the treatment of Chagas\u2019 disease.&nbsp;<\/strong>Lima M, Tulloch L, Corpas Lopez V, Carvalho S, Wall R, Milne R, Rico E, Patterson S, Gilbert I, Moniz S, MacLean L, Torrie L, Morgillo C, Horn D, Zuccotto F, Wyllie S.&nbsp;<em>Antimicrob. Agents Chemother.<\/em>&nbsp;2022 Jan 18;66(1):e0153521. doi: 10.1128\/AAC.01535-21. Epub 2021 Oct 4. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34606338\/\">34606338<\/a>&nbsp;Free PMC article<\/p>\n\n\n\n<p><strong>Genome-scale RNAi screens in African trypanosomes.&nbsp;<\/strong>Horn D.&nbsp;<em>Trends Parasitol.&nbsp;<\/em>2022 Feb;38(2):160-173. doi: 10.1016\/j.pt.2021.09.002. Epub 2021 Sep 24. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34580035\/\">34580035<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2021<\/strong><\/h4>\n\n\n\n<p><strong>Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes.&nbsp;<\/strong>Faria J, Luzak V, M\u00fcller LSM, Brink BG, Hutchinson S, Glover L, Horn D, Siegel TN.&nbsp;<em>Nat Microbiol.&nbsp;<\/em>2021 Mar;6(3):289-300. &nbsp;doi: 10.1038\/s41564-020-00833-4. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33432154\/\">33432154<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2020<\/strong><\/h4>\n\n\n\n<p><strong>Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs.&nbsp;<\/strong>Giordani F, Paape D, Vincent IM, Pountain AW, Fernandez-Cortes F, Rico E, Zhang N, Morrison LJ, Freund Y, Witty MJ, Peter R, Edwards DY, Wilkes J, Van der Hooft J, Regnault C, Read KD, Horn D, Field MC, Barrett MP.&nbsp;<em>PLoS Pathogens<\/em>. 2020 Nov 3;16(11):e1008932. doi: 10.1371\/journal.ppat.1008932. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33141865\/\">33141865<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Quintana JF, Bueren-Calabuig J, Zuccotto F, de Koning HP, Horn D, Field MC.&nbsp;<em>PLoS Negl Trop Dis.<\/em>&nbsp;2020 Jul 9;14(7):e0008458. doi: 10.1371\/journal.pntd.0008458. eCollection 2020 Jul. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32644992\/\">32644992<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes.&nbsp;<\/strong>Zoltner M, Campagnaro GD, Taleva G, Burrell A, Cerone M, Leung KF, Achcar F, Horn D, Vaughan S, Gadelha C, Z\u00edkov\u00e1 A, Barrett MP, de Koning HP, Field MC.&nbsp;<em>J Biol Chem.&nbsp;<\/em>2020 Apr 30. pii: jbc.RA120.012355. doi: 10.1074\/jbc.RA120.012355. Epub 2020 Apr 30. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32354742\/\">32354742<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Setting our sights on infectious diseases.&nbsp;<\/strong>De Rycker M, Horn D, Aldridge B, Amewu RK, Barry CE 3rd, Buckner FS, Cook S, Ferguson MAJ, Gobeau N, Herrmann J, Herrling P, Hope W, Keiser J, Lafuente-Monasterio MJ, Leeson PD, Leroy D, Manjunatha UH, McCarthy J, Miles TJ, Mizrahi V, Moshynets O, Niles J, Overington JP, Pottage J, Rao SPS, Read KD, Ribeiro I, Silver LL, Southern J, Spangenberg T, Sundar S, Taylor C, Van Voorhis W, White NJ, Wyllie S, Wyatt PG, Gilbert IH.&nbsp;<em>ACS Infect Dis.<\/em>&nbsp;2020 Jan 10;6(1):3-13. doi: 10.1021\/acsinfecdis.9b00371. Epub 2019 Dec 6. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31808676\/\">31808676<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2019<\/strong><\/h4>\n\n\n\n<p><strong>Monoallelic expression and epigenetic inheritance sustained by a&nbsp;<em>Trypanosoma brucei&nbsp;<\/em>variant surface glycoprotein exclusion complex.&nbsp;<\/strong>Faria J, Glover L, Hutchinson S, Boehm C, Field MC, Horn D.&nbsp;<em>Nat Commun<\/em>. 2019 Jul 9;10(1):3023. doi: 10.1038\/s41467-019-10823-8. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31289266\/\">31289266<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Persistent DNA damage foci and DNA replication with a broken chromosome in the African trypanosome.&nbsp;<\/strong>Glover L, Marques CA, Suska O, Horn D.&nbsp;<em>MBio<\/em>. 2019 Jul 9;10(4). pii: e01252-19. doi: 10.1128\/mBio.01252-19. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31289179\/\">31289179<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Chemogenomic profiling of anti-leishmanial efficacy and resistance in the related kinetoplastid parasite&nbsp;<em>Trypanosoma brucei<\/em>.&nbsp;<\/strong>Collett CF, Kitson C, Baker N, Steele-Stallard HB, Santrot MV, Hutchinson S, Horn D, Alsford S.&nbsp;<em>Antimicrob Agents Chemother.<\/em>&nbsp;2019 Jul 25;63(8). pii: e00795-19. doi: 10.1128\/AAC.00795-19. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31160283\/\">31160283<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>A post-transcriptional respiratome regulon in trypanosomes.&nbsp;<\/strong>Trenaman A, Glover L, Hutchinson S, Horn D.&nbsp;<em>Nucleic Acids Res.&nbsp;<\/em>2019 Nucleic Acids Res. 2019 Jul 26;47(13):7063-7077. doi: 10.1093\/nar\/gkz455. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31127277\/\">31127277<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.&nbsp;<\/strong>Wyllie S, Brand S, Thomas M, De Rycker M, Chung CW, Pena I, Bingham RP, Bueren-Calabuig JA, Cantizani J, Cebrian D, Craggs PD, Ferguson L, Goswami P, Hobrath J, Howe J, Jeacock L, Ko EJ, Korczynska J, MacLean L, Manthri S, Martinez MS, Mata-Cantero L, Moniz S, N\u00fchs A, Osuna-Cabello M, Pinto E, Riley J, Robinson S, Rowland P, Simeons FRC, Shishikura Y, Spinks D, Stojanovski L, Thomas J, Thompson S, Viayna Gaza E, Wall RJ, Zuccotto F, Horn D, Ferguson MAJ, Fairlamb AH, Fiandor JM, Martin J, Gray DW, Miles TJ, Gilbert IH, Read KD, Marco M, Wyatt PG.&nbsp;<em>Proc Natl Acad Sci U S A.<\/em>&nbsp;2019 May 7;116(19):9318-9323. doi: 10.1073\/pnas.1820175116. Epub 2019 Apr 8. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30962368\/\">30962368<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Pharmacological validation of N-myristoyltransferase as a drug target in&nbsp;<em>Leishmania donovani<\/em>.&nbsp;<\/strong>Corpas-Lopez V, Moniz S, Thomas M, Wall RJ, Torrie LS, Zander-Dinse D, Tinti M, Brand S, Stojanovski L, Manthri S, Hallyburton I, Zuccotto F, Wyatt PG, De Rycker M, Horn D, Ferguson MAJ, Clos J, Read KD, Fairlamb AH, Gilbert IH, Wyllie S.&nbsp;<em>ACS Infect Dis.&nbsp;<\/em>2019 Jan 11;5(1):111-122. doi: 10.1021\/acsinfecdis.8b00226. Epub 2018 Nov 12. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30380837\/\">30380837<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2018<\/strong><\/h4>\n\n\n\n<p><strong>Gluconeogenesis using glycerol as a substrate in bloodstream-form&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Kov\u00e1\u0159ov\u00e1 J, Nagar R, Faria J, Ferguson MAJ, Barrett MP, Horn D.&nbsp;<em>PLoS Pathog<\/em>. 2018 Dec 27;14(12):e1007475. doi: 10.1371\/journal.ppat.1007475. eCollection 2018 Dec. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30589893\/\">3058989<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Insights into antitrypanosomal drug mode-of-action from cytology-based profiling.<\/strong>&nbsp;Thomas JA, Baker N, Hutchinson S, Dominicus C, Trenaman A, Glover L, Alsford S, Horn D.&nbsp;<em>PLoS Negl Trop Dis.<\/em>&nbsp;2018 Nov 26;12(11):e0006980. doi: 10.1371\/journal.pntd.0006980. eCollection 2018 Nov. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30475806\/\">30475806&nbsp;<\/a>Free PMC Article<\/p>\n\n\n\n<p><strong>Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.<\/strong>&nbsp;Wall RJ, Rico E, Lukac I, Zuccotto F, Elg S, Gilbert IH, Freund Y, Alley MRK, Field MC, Wyllie S, Horn D.&nbsp;<em>Proc Natl Acad Sci U S A.<\/em>&nbsp;2018 Sep 18;115(38):9616-9621. doi: 10.1073\/pnas.1807915115. Epub 2018 Sep 5. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30185555\/\">30185555<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Faster growth with shorter antigens can explain a VSG hierarchy during African trypanosome infections: a feint attack by parasites.&nbsp;<\/strong>Liu D, Albergante L, Newman TJ, Horn D.&nbsp;<em>Sci Rep.<\/em>&nbsp;2018 Jul 19;8(1):10922. doi: 10.1038\/s41598-018-29296-8. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30026531\/\">30026531<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Antitrypanosomal 8-hydroxy-naphthyridines are chelators of divalent transition metals.&nbsp;<\/strong>Wall RJ, Moniz S, Thomas MG, Norval S, Ko EJ, Marco M, Miles TJ, Gilbert IH, Horn D, Fairlamb AH, Wyllie S.&nbsp;<em>Antimicrob Agents Chemother.<\/em>&nbsp;2018 Jul 27;62(8). pii: e00235-18. doi: 10.1128\/AAC.00235-18. Print 2018 Aug. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29844044\/\">29844044<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes.&nbsp;<\/strong>Rico E, Jeacock L, Kov\u00e1\u0159ov\u00e1 J, Horn D.&nbsp;<em>Sci Rep.<\/em>&nbsp;2018 May 21;8(1):7960. doi: 10.1038\/s41598-018-26303-w. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29785042\/\">29785042<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Steketee PC, Vincent IM, Achcar F, Giordani F, Kim DH, Creek DJ, Freund Y, Jacobs R, Rattigan K, Horn D, Field MC, MacLeod A, Barrett MP.&nbsp;<em>PLoS Negl Trop Dis.<\/em>&nbsp;2018 May 14;12(5):e0006450. doi: 10.1371\/journal.pntd.0006450. eCollection 2018 May. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29758036\/\">29758036<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Melarsoprol resistance in African trypanosomiasis.&nbsp;<\/strong>Fairlamb AH, Horn D.&nbsp;<em>Trends Parasitol.<\/em>&nbsp;2018 Jun;34(6):481-492. doi: 10.1016\/j.pt.2018.04.002. Epub 2018 Apr 25. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29705579\/\">29705579<\/a>&nbsp;Free Article<\/p>\n\n\n\n<p><strong>Codon usage bias controls mRNA and protein abundance in trypanosomatids.&nbsp;<\/strong>Jeacock L, Faria J, Horn D.&nbsp;<em>Elife.<\/em>&nbsp;2018 Mar 15;7. pii: e32496. doi: 10.7554\/eLife.32496. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29543155\/\">29543155<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.&nbsp;<\/strong>Zhang N, Zoltner M, Leung KF, Scullion P, Hutchinson S, Del Pino RC, Vincent IM, Zhang YK, Freund YR, Alley MRK, Jacobs RT, Read KD, Barrett MP, Horn D, Field MC.&nbsp;<em>PLoS Pathog.<\/em>&nbsp;2018 Feb 9;14(2):e1006850. doi: 10.1371\/journal.ppat.1006850. eCollection 2018 Feb. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29425238\/\">29425238<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2017<\/strong><\/h4>\n\n\n\n<p><strong>Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs.&nbsp;<\/strong>Meredith EL, Kumar A, Konno A, Szular J, Alsford S, Seifert K, Horn D, Wilkinson SR.&nbsp;<em>Mol Microbiol.<\/em>&nbsp;2017 Oct;106(2):207-222. doi: 10.1111\/mmi.13767. Epub 2017 Aug 31. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28792090\/\">28792090<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in<em>&nbsp;Trypanosoma brucei.&nbsp;<\/em><\/strong>Stortz JA, Serafim TD, Alsford S, Wilkes J, Fernandez-Cortes F, Hamilton G, Briggs E, Lemgruber L, Horn D, Mottram JC, McCulloch R.&nbsp;<em>PLoS Pathog.<\/em>&nbsp;2017 Jul 24;13(7):e1006477. doi: 10.1371\/journal.ppat.1006477. eCollection 2017 Jul. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28742144\/\">28742144<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Ornithine uptake and the modulation of drug sensitivity in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Macedo JP, Currier RB, Wirdnam C, Horn D, Alsford S, Rentsch D.&nbsp;<em>FASEB J.<\/em>&nbsp;2017 Oct;31(10):4649-4660. doi: 10.1096\/fj.201700311R. Epub 2017 Jul 5. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28679527\/\">28679527<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity.&nbsp;<\/strong>Jeacock L, Baker N, Wiedemar N, M\u00e4ser P, Horn D.&nbsp;<em>PLoS Pathog.<\/em>&nbsp;2017 Mar 30;13(3):e1006307. doi: 10.1371\/journal.ppat.1006307. eCollection 2017 Mar. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28358927\/\">28358927<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in<em>&nbsp;Trypanosoma brucei.&nbsp;<\/em><\/strong>Rico E, Ivens A, Glover L, Horn D, Matthews KR.&nbsp;<em>PLoS Pathog.<\/em>&nbsp;2017 Mar 23;13(3):e1006279. doi: 10.1371\/journal.ppat.1006279. eCollection 2017 Mar. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28334017\/\">28334017<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.&nbsp;<\/strong>Field MC, Horn D, Fairlamb AH, Ferguson MA, Gray DW, Read KD, De Rycker M, Torrie LS, Wyatt PG, Wyllie S, Gilbert IH.&nbsp;<em>Nat Rev Microbiol.<\/em>&nbsp;2017 Feb 27;15(4):217-231. doi: 10.1038\/nrmicro.2016.193. [Epub ahead of print] Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28239154\/\">28239154<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2016<\/h4>\n\n\n\n<p><strong>Exploiting the Achilles\u2019 heel of membrane trafficking in trypanosomes.&nbsp;<\/strong>Zoltner M, Horn D, de Koning HP, Field MC.&nbsp;<em>Curr Opin Microbiol.<\/em>&nbsp;2016 Dec;34:97-103. doi: 10.1016\/j.mib.2016.08.005. Epub 2016 Sep 9. Review. PMID: 27614711 Free PMC Article<\/p>\n\n\n\n<p><strong>High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes.&nbsp;<\/strong>Hutchinson S, Glover L, Horn D.&nbsp;<em>BMC Genomics.<\/em>&nbsp;2016 Oct 18;17(1):806. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27756224\/\">27756224<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>The role of folate transport in antifolate drug action in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Dewar S, Sienkiewicz N, Ong HB, Wall RJ, Horn D, Fairlamb AH.&nbsp;<em>J Biol Chem.<\/em>&nbsp;2016 Nov 18;291(47):24768-24778. Epub 2016 Oct 4. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27703008\/\">27703008<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression.&nbsp;<\/strong>Maishman L, Obado SO, Alsford S, Bart JM, Chen WM, Ratushny AV, Navarro M, Horn D, Aitchison JD, Chait BT, Rout MP, Field MC.&nbsp;<em>Nucleic Acids Res.<\/em>&nbsp;2016 Dec 15;44(22):10554-10570. Epub 2016 Sep 12. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27625397\/\">27625397<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes.&nbsp;<\/strong>Glover L, Hutchinson S, Alsford S, Horn D.&nbsp;<em>Proc Natl Acad Sci U S A.<\/em>&nbsp;2016 Jun 28;113(26):7225-30. doi: 10.1073\/pnas.1600344113. Epub 2016 May 25. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27226299\/\">27226299<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>How antiparasitic drugs work \u2013 and sometimes stop working!&nbsp;<\/strong>Horn D.&nbsp;<em>PLoS Pathog.<\/em>&nbsp;2016 May 5;12(5):e1005430. doi: 10.1371\/journal.ppat.1005430. eCollection 2016 May. No abstract available. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27149375\/\">27149375<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Epigenetic regulation of virulence gene expression in parasitic protozoa.&nbsp;<\/strong>Duraisingh MT, Horn D.&nbsp;<em>Cell Host Microbe.<\/em>&nbsp;2016 May 11;19(5):629-40. doi: 10.1016\/j.chom.2016.04.020. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27173931\/\">27173931<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Comparative genomics of drug resistance in&nbsp;<em>Trypanosoma brucei rhodesiense.&nbsp;<\/em><\/strong>Graf FE, Ludin P, Arquint C, Schmidt RS, Schaub N, Kunz Renggli C, Munday JC, Krezdorn J, Baker N, Horn D, Balmer O, Caccone A, de Koning HP, M\u00e4ser P.&nbsp;<em>Cell Mol Life Sci.<\/em>&nbsp;2016 Sep;73(17):3387-400. doi: 10.1007\/s00018-016-2173-6. Epub 2016 Mar 14. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26973180\/\">26973180<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Pentamidine Is not a permeant but a nanomolar inhibitor of the&nbsp;<em>Trypanosoma brucei<\/em>&nbsp;aquaglyceroporin-2.&nbsp;<\/strong>Song J, Baker N, Rothert M, Henke B, Jeacock L, Horn D, Beitz E.&nbsp;<em>PLoS Pathog.<\/em>&nbsp;2016 Feb 1;12(2):e1005436. doi: 10.1371\/journal.ppat.1005436. eCollection 2016 Feb. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26828608\/\">26828608<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2015<\/h4>\n\n\n\n<p><strong>Modulation of the surface proteome through multiple ubiquitylation pathways in African trypanosomes.&nbsp;<\/strong>Zoltner M, Leung KF, Alsford S, Horn D, Field MC.&nbsp;<em>PLoS Pathog.<\/em>&nbsp;2015 Oct 22;11(10):e1005236. doi: 10.1371\/journal.ppat.1005236. eCollection 2015 Oct. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26492041\/\">26492041<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes.&nbsp;<\/strong>Baker N, Hamilton G, Wilkes JM, Hutchinson S, Barrett MP, Horn D.&nbsp;<em>Proc Natl Acad Sci U S A.<\/em>&nbsp;2015 Jul 21;112(29):9112-7. doi: 10.1073\/pnas.1505411112. Epub 2015 Jul 6. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26150481\/\">26150481<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical&nbsp;<em>Trypanosoma brucei gambiense<\/em>&nbsp;isolates.&nbsp;<\/strong>Graf FE, Baker N, Munday JC, de Koning HP, Horn D, M\u00e4ser P.&nbsp;<em>Int J Parasitol Drugs Drug Resist.&nbsp;<\/em>2015 May 7;5(2):65-8. doi: 10.1016\/j.ijpddr.2015.04.002. eCollection 2015 Aug. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26042196\/\">26042196<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong><em>Trypanosoma brucei<\/em>&nbsp;J protein 2 is a stress inducible and essential Hsp40.&nbsp;<\/strong>Ludewig MH, Boshoff A, Horn D, Blatch GL.&nbsp;<em>Int J Biochem Cell Biol.<\/em>&nbsp;2015 Mar;60:93-8. doi: 10.1016\/j.biocel.2014.12.016. Epub 2015 Jan 3. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25562516\/\">25562516<\/a><\/p>\n\n\n\n<p><strong>Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes.&nbsp;<\/strong>Glover L, Alsford S, Baker N, Turner DJ, Sanchez-Flores A, Hutchinson S, Hertz-Fowler C, Berriman M, Horn D.&nbsp;<em>Nat Protoc.&nbsp;<\/em>2015 Jan;10(1):106-33. doi: 10.1038\/nprot.2015.005. Epub 2014 Dec 11. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25502887\/\">25502887<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2014<\/h4>\n\n\n\n<p><strong>Locus-specific control of DNA resection and suppression of subtelomeric&nbsp;<em>VSG<\/em>&nbsp;recombination by HAT3 in the African trypanosome.&nbsp;<\/strong>Glover L, Horn D.&nbsp;<em>Nucleic Acids Res.<\/em>&nbsp;2014 Nov 10;42(20):12600-13. doi: 10.1093\/nar\/gku900. Epub 2014 Oct 9. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25300492\/\">25300492<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Antiparasitic chemotherapy: from genomes to mechanisms.&nbsp;<\/strong>Horn D, Duraisingh MT.&nbsp;<em>Annu Rev Pharmacol Toxicol.<\/em>&nbsp;2014;54:71-94. doi: 10.1146\/annurev-pharmtox-011613-135915. Epub 2013 Sep 11. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24050701\/\">24050701<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Antigenic variation in African trypanosomes.&nbsp;<\/strong>Horn D.&nbsp;<em>Mol Biochem Parasitol.<\/em>&nbsp;2014 Jul;195(2):123-9. doi: 10.1016\/j.molbiopara.2014.05.001. Epub 2014 May 22. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24859277\/\">24859277<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Cathepsin-L can resist lysis by human serum in&nbsp;<em>Trypanosoma brucei brucei.&nbsp;<\/em><\/strong>Alsford S, Currier RB, Guerra-Assun\u00e7\u00e3o JA, Clark TG, Horn D.&nbsp;<em>PLoS Pathog<\/em>. 2014 May 15;10(5):e1004130. doi: 10.1371\/journal.ppat.1004130. eCollection 2014 May. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24830321\/\">24830321<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Genome-wide dissection of the quorum sensing signalling pathway in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Mony BM, MacGregor P, Ivens A, Rojas F, Cowton A, Young J, Horn D, Matthews K.&nbsp;<em>Nature.<\/em>&nbsp;2014 Jan 30;505(7485):681-685. doi: 10.1038\/nature12864. Epub 2013 Dec 15. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24336212\/\">24336212<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong><em>Trypanosoma brucei<\/em>&nbsp;aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.<\/strong>Munday JC, Eze AA, Baker N, Glover L, Clucas C, Aguinaga Andr\u00e9s D, Natto MJ, Teka IA, McDonald J, Lee RS, Graf FE, Ludin P, Burchmore RJ, Turner CM, Tait A, MacLeod A, M\u00e4ser P, Barrett MP, Horn D, De Koning HP.&nbsp;<em>J Antimicrob Chemother.<\/em>&nbsp;2014 Mar;69(3):651-63. doi: 10.1093\/jac\/dkt442. Epub 2013 Nov 13. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24235095\/\">24235095<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>High-throughput decoding of drug targets and drug resistance mechanisms in African trypanosomes.&nbsp;<\/strong>Horn D.&nbsp;<em>Parasitology.<\/em>&nbsp;2014 Jan;141(1):77-82. doi: 10.1017\/S0031182013000243. Epub 2013 Apr 8. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23561654\/\">23561654<\/a><\/p>\n\n\n\n<p><strong><em>Trypanosoma brucei<\/em>&nbsp;subtelomeres: Monoallelic expression and antigenic variation.&nbsp;<\/strong>Figueiredo L, Horn D<em>.&nbsp;<\/em><em>Subtelomeres.<\/em>&nbsp;Springer. 2014. Ch 7:137-152. Ed. Edward Louis.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2013<\/h4>\n\n\n\n<p><strong>PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome.&nbsp;<\/strong>Rudd SG, Glover L, Jozwiakowski SK, Horn D, Doherty AJ.&nbsp;<em>Mol Cell.<\/em>&nbsp;2013 Nov 21;52(4):554-65. doi: 10.1016\/j.molcel.2013.10.034. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24267450\/\">24267450<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Aquaporin 2 mutations in&nbsp;<em>Trypanosoma brucei gambiense<\/em>&nbsp;field isolates correlate with decreased susceptibility to pentamidine and melarsoprol.&nbsp;<\/strong>Graf FE, Ludin P, Wenzler T, Kaiser M, Brun R, Pyana PP, B\u00fcscher P, de Koning HP, Horn D, M\u00e4ser P.&nbsp;<em>PLoS Negl Trop Dis.<\/em>&nbsp;2013 Oct 10;7(10):e2475. doi: 10.1371\/journal.pntd.0002475. eCollection 2013. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24130910\/\">24130910<\/a>&nbsp;Free PMC Article<strong>Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in&nbsp;<em>VSG<\/em>&nbsp;expression control.&nbsp;<\/strong>Glover L, Hutchinson S, Alsford S, McCulloch R, Field MC, Horn D.&nbsp;<em>Cell Microbiol.<\/em>&nbsp;2013 Dec;15(12):1984-93. doi: 10.1111\/cmi.12215. Epub 2013 Oct 10. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24047558\/\">24047558<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA.&nbsp;<\/strong>Gould MK, Bachmaier S, Ali JA, Alsford S, Tagoe DN, Munday JC, Schnaufer AC, Horn D, Boshart M, de Koning HP.&nbsp;<em>Antimicrob Agents Chemother.<\/em>&nbsp;2013 Oct;57(10):4882-93. doi: 10.1128\/AAC.00508-13. Epub 2013 Jul 22. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23877697\/\">23877697<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich\u2019s vision of chemotherapy.&nbsp;<\/strong>Alsford S, Field MC, Horn D.&nbsp;<em>Trends Parasitol.<\/em>&nbsp;2013 May;29(5):207-12. doi: 10.1016\/j.pt.2013.03.004. Epub 2013 Apr 17. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23601931\/\">23601931<\/a><\/p>\n\n\n\n<p><strong>DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes.&nbsp;<\/strong>Glover L, Alsford S, Horn D.&nbsp;<em>PLoS Pathog.<\/em>&nbsp;2013 Mar;9(3):e1003260. doi: 10.1371\/journal.ppat.1003260. Epub 2013 Mar 28. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23555264\/\">23555264<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Genetic dissection of drug resistance in trypanosomes.&nbsp;<\/strong>Alsford S, Kelly JM, Baker N, Horn D.&nbsp;<em>Parasitology.<\/em>&nbsp;2013 Oct;140(12):1478-91. doi: 10.1017\/S003118201300022X. Epub 2013 Apr 3. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23552488\/\">23552488<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story.&nbsp;<\/strong>Baker N, de Koning HP, M\u00e4ser P, Horn D.&nbsp;<em>Trends Parasitol.<\/em>&nbsp;2013 Mar;29(3):110-8. doi: 10.1016\/j.pt.2012.12.005. Epub 2013 Jan 30. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23375541\/\">23375541<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2012<\/h4>\n\n\n\n<p><strong>Cell-cycle-regulated control of&nbsp;<em>VSG<\/em>&nbsp;expression site silencing by histones and histone chaperones ASF1A and CAF-1b in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Alsford S, Horn D.&nbsp;<em>Nucleic Acids Res.<\/em>&nbsp;2012 Nov 1;40(20):10150-60. doi: 10.1093\/nar\/gks813. Epub 2012 Aug 31. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22941664\/\">22941664<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Telomeres, tethers and trypanosomes.&nbsp;<\/strong>Field MC, Horn D, Alsford S, Koreny L, Rout MP.&nbsp;<em>Nucleus.<\/em>&nbsp;2012 Nov-Dec;3(6):478-86. doi: 10.4161\/nucl.22167. Epub 2012 Sep 19. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22992703\/\">22992703<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes.&nbsp;<\/strong>Baker N, Glover L, Munday JC, Aguinaga Andr\u00e9s D, Barrett MP, de Koning HP, Horn D.&nbsp;<em>Proc Natl Acad Sci U S A.&nbsp;<\/em>2012 Jul 3;109(27):10996-1001. doi: 10.1073\/pnas.1202885109. Epub 2012 Jun 18. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22711816\/\">22711816<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes.&nbsp;<\/strong>Alsford S, duBois K, Horn D, Field MC.&nbsp;<em>Expert Rev Mol Med.<\/em>&nbsp;2012 May 29;14:e13. doi: 10.1017\/erm.2012.7. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22640744\/\">22640744<\/a><\/p>\n\n\n\n<p><strong>NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions.&nbsp;<\/strong>DuBois KN, Alsford S, Holden JM, Buisson J, Swiderski M, Bart JM, Ratushny AV, Wan Y, Bastin P, Barry JD, Navarro M, Horn D, Aitchison JD, Rout MP, Field MC.&nbsp;<em>PLoS Biol.<\/em>&nbsp;2012;10(3):e1001287. doi: 10.1371\/journal.pbio.1001287. Epub 2012 Mar 27. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22479148\/\">22479148<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Trypanosomal histone \u03b3H2A and the DNA damage response.&nbsp;<\/strong>Glover L, Horn D.&nbsp;<em>Mol Biochem Parasitol.<\/em>&nbsp;2012 May;183(1):78-83. doi: 10.1016\/j.molbiopara.2012.01.008. Epub 2012 Feb 14. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22353557\/\">22353557<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Inhibitors of human histone deacetylase with potent activity against the African trypanosome&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Kelly JM, Taylor MC, Horn D, Loza E, Kalvinsh I, Bj\u00f6rkling F.&nbsp;<em>Bioorg Med Chem Lett.<\/em>&nbsp;2012 Mar 1;22(5):1886-90. doi: 10.1016\/j.bmcl.2012.01.072. Epub 2012 Jan 28. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22326398\/\">22326398<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>High-throughput decoding of antitrypanosomal drug efficacy and resistance.&nbsp;<\/strong>Alsford S, Eckert S, Baker N, Glover L, Sanchez-Flores A, Leung KF, Turner DJ, Field MC, Berriman M, Horn D.&nbsp;<em>Nature<\/em>. 2012 Jan 25;482(7384):232-6. doi: 10.1038\/nature10771. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22278056\/\">22278056<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2011<\/h4>\n\n\n\n<p><strong>High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome.&nbsp;<\/strong>Alsford S, Turner DJ, Obado SO, Sanchez-Flores A, Glover L, Berriman M, Hertz-Fowler C, Horn D.&nbsp;<em>Genome Res.<\/em>&nbsp;2011 Jun;21(6):915-24. doi: 10.1101\/gr.115089.110. Epub 2011 Mar 1. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21363968\/\">21363968<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Elongator protein 3b negatively regulates ribosomal DNA transcription in african trypanosomes.&nbsp;<\/strong>Alsford S, Horn D.&nbsp;<em>Mol Cell Biol.<\/em>&nbsp;2011 May;31(9):1822-32. doi: 10.1128\/MCB.01026-10. Epub 2011 Feb 28. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21357738\/\">21357738<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6.&nbsp;<\/strong>Baker N, Alsford S, Horn D.&nbsp;<em>Mol Biochem Parasitol.<\/em>&nbsp;2011 Mar;176(1):55-7. doi: 10.1016\/j.molbiopara.2010.11.010. Epub 2010 Nov 18. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21093499\/\">21093499<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Microhomology-mediated deletion and gene conversion in African trypanosomes.&nbsp;<\/strong>Glover L, Jun J, Horn D.&nbsp;<em>Nucleic Acids Res.<\/em>&nbsp;2011 Mar;39(4):1372-80. doi: 10.1093\/nar\/gkq981. Epub 2010 Oct 21. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20965968\/\">20965968<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2010<\/h4>\n\n\n\n<p><strong>Molecular mechanisms underlying the control of antigenic variation in African trypanosomes.&nbsp;<\/strong>Horn D, McCulloch R.&nbsp;<em>Curr Opin Microbiol.<\/em>&nbsp;2010 Dec;13(6):700-5. doi: 10.1016\/j.mib.2010.08.009. Epub 2010 Sep 29. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20884281\/\">20884281<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Histone deacetylases play distinct roles in telomeric&nbsp;<em>VSG<\/em>&nbsp;expression site silencing in African trypanosomes<\/strong>. Wang QP, Kawahara T, Horn D.&nbsp;<em>Mol Microbiol.<\/em>&nbsp;2010 Sep;77(5):1237-45. doi: 10.1111\/j.1365-2958.2010.07284.x. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20624217\/\">20624217<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease.&nbsp;<\/strong>Alsford S, Kemp LE, Kawahara T, Horn D.&nbsp;<em>Mol Biochem Parasitol.<\/em>&nbsp;2010 Nov;174(1):70-3. doi: 10.1016\/j.molbiopara.2010.06.006. Epub 2010 Jun 14. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/20558212\/\">20558212<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2009<\/h4>\n\n\n\n<p><strong>What has DNA sequencing revealed about the&nbsp;<em>VSG<\/em>&nbsp;expression sites of African trypanosomes?&nbsp;<\/strong>McCulloch R, Horn D.&nbsp;<em>Trends Parasitol.<\/em>&nbsp;2009 Aug;25(8):359-63. doi: 10.1016\/j.pt.2009.05.007. Epub 2009 Jul 23. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19632154\/\">19632154<\/a><\/p>\n\n\n\n<p><strong>Antigenic variation: extending the reach of telomeric silencing.&nbsp;<\/strong>Horn D.&nbsp;<em>Curr Biol.<\/em>&nbsp;2009 Jun 23;19(12):R496-8. doi: 10.1016\/j.cub.2009.04.049. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19549499\/\">19549499<\/a>&nbsp;Free Article<\/p>\n\n\n\n<p><strong>Site-specific DNA double-strand breaks greatly increase s transformation efficiency in<em>&nbsp;Trypanosoma brucei.&nbsp;<\/em><\/strong>Glover L, Horn D.&nbsp;<em>Mol Biochem Parasitol.<\/em>&nbsp;2009 Aug;166(2):194-7. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19459229\/\">19459229<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>DNA breaks as triggers for antigenic variation in African trypanosomes.&nbsp;<\/strong>Alsford S, Horn D, Glover L.&nbsp;<em>Genome Biol.&nbsp;<\/em>2009;10(6):223. doi: 10.1186\/gb-2009-10-6-223. Epub 2009 Jun 8. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19519956\/\">19519956<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2008<\/h4>\n\n\n\n<p><strong>Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.&nbsp;<\/strong>Kawahara T, Siegel TN, Ingram AK, Alsford S, Cross GA, Horn D.&nbsp;<em>Mol Microbiol.<\/em>&nbsp;2008 Aug;69(4):1054-68. doi: 10.1111\/j.1365-2958.2008.06346.x. Epub 2008 Jul 9. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18631159\/\">18631159<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Single-locus targeting constructs for reliable regulated RNAi and transgene expression in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Alsford S, Horn D.&nbsp;<em>Mol Biochem Parasitol.<\/em>&nbsp;2008 Sep;161(1):76-9. doi: 10.1016\/j.molbiopara.2008.05.006. Epub 2008 Jun 7. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18588918\/\">18588918<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Analysis of small GTPase function in trypanosomes.&nbsp;<\/strong>Field MC, Horn D, Carrington M.&nbsp;<em>Methods Enzymol.<\/em>&nbsp;2008;438:57-76. doi: 10.1016\/S0076-6879(07)38005-1. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18413241\/\">18413241<\/a><\/p>\n\n\n\n<p><strong>A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.&nbsp;<\/strong>Wilkinson SR, Taylor MC, Horn D, Kelly JM, Cheeseman I.&nbsp;<em>Proc Natl Acad Sci U S A.<\/em>&nbsp;2008 Apr 1;105(13):5022-7. doi: 10.1073\/pnas.0711014105. Epub 2008 Mar 26. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18367671\/\">18367671<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes.&nbsp;<\/strong>Glover L, McCulloch R, Horn D.&nbsp;<em>Nucleic Acids Res.&nbsp;<\/em>2008 May;36(8):2608-18. doi: 10.1093\/nar\/gkn104. Epub 2008 Mar 11. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18334531\/\">18334531<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Siegel TN, Kawahara T, Degrasse JA, Janzen CJ, Horn D, Cross GA.&nbsp;<em>Mol Microbiol.<\/em>&nbsp;2008 Feb;67(4):762-71. doi: 10.1111\/j.1365-2958.2007.06079.x. Epub 2007 Dec 30. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18179414\/\">18179414<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids.&nbsp;<\/strong>Horn D.&nbsp;<em>BMC Genomics.<\/em>&nbsp;2008 Jan 3;9:2. doi: 10.1186\/1471-2164-9-2. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18173843\/\">18173843<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Histone deacetylases.&nbsp;<\/strong>Horn D.&nbsp;<em>Adv Exp Med Biol.<\/em>&nbsp;2008;625:81-6. doi: 10.1007\/978-0-387-77570-8_7. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18365660\/\">18365660<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2007<\/h4>\n\n\n\n<p><strong>Introducing histone modification in trypanosomes.&nbsp;<\/strong>Horn D.&nbsp;<em>Trends Parasitol.<\/em>&nbsp;2007 Jun;23(6):239-42. Epub 2007 Apr 11. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17433777\/\">17433777<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>RNA polymerase I transcription stimulates homologous recombination in<em>&nbsp;Trypanosoma brucei.&nbsp;<\/em><\/strong>Alsford S, Horn D.&nbsp;<em>Mol Biochem Parasitol.<\/em>&nbsp;2007 May;153(1):77-9. Epub 2007 Jan 21. No abstract available. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17316839\/\">17316839<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest.&nbsp;<\/strong>Glover L, Alsford S, Beattie C, Horn D.&nbsp;<em>Nucleic Acids Res.<\/em>&nbsp;2007;35(3):872-80. Epub 2007 Jan 23. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17251198\/\">17251198<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation.&nbsp;<\/strong>Alsford S, Kawahara T, Isamah C, Horn D.&nbsp;<em>Mol Microbiol.<\/em>&nbsp;2007 Feb;63(3):724-36. Epub 2007 Jan 4. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17214740\/\">17214740<\/a>&nbsp;Free Article<\/p>\n\n\n\n<p><strong>Deletion of the&nbsp;<em>Trypanosoma brucei<\/em>&nbsp;superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.&nbsp;<\/strong>Prathalingham SR, Wilkinson SR, Horn D, Kelly JM.&nbsp;<em>Antimicrob Agents Chemother.<\/em>&nbsp;2007 Feb;51(2):755-8. Epub 2006 Dec 4. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17145786\/\">17145786<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Chromosome structure and dynamics.&nbsp;<\/strong>Renauld H, Kelly JM, Horn D. In: Barry, D; Mottram, J; McCulloch, R; Acosta-Serrano, A; Renauld, H, (eds.) 2007. pp. 91-132. Trypanosomes \u2013 After the Genome. Horizon Scientific Press, Norwich, UK.,<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2006<\/h4>\n\n\n\n<p><strong>Chromosome-wide analysis of gene function by RNA interference in the African trypanosome.&nbsp;<\/strong>Subramaniam C, Veazey P, Redmond S, Hayes-Sinclair J, Chambers E, Carrington M, Gull K, Matthews K, Horn D, Field MC.&nbsp;<em>Eukaryot Cell.<\/em>&nbsp;2006 Sep;5(9):1539-49. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16963636\/\">16963636<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Functional characterisation of the iron superoxide dismutase gene repertoire in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Wilkinson SR, Prathalingam SR, Taylor MC, Ahmed A, Horn D, Kelly JM.&nbsp;<em>Free Radic Biol Med.<\/em>&nbsp;2006 Jan 15;40(2):198-209. Epub 2005 Aug 18. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16413403\/\">16413403<\/a><\/p>\n\n\n\n<p><strong>Repression of polymerase I-mediated gene expression at&nbsp;<em>Trypanosoma brucei&nbsp;<\/em>telomeres.&nbsp;<\/strong>Glover L, Horn D.&nbsp;<em>EMBO Rep.<\/em>&nbsp;2006 Jan;7(1):93-9. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16311518\/\">16311518<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2005<\/h4>\n\n\n\n<p><strong>Tagging a&nbsp;<em>T. brucei<\/em>&nbsp;RRNA locus improves s transfection efficiency and circumvents inducible expression position effects.&nbsp;<\/strong>Alsford S, Kawahara T, Glover L, Horn D.&nbsp;<em>Mol Biochem Parasitol.<\/em>&nbsp;2005 Dec;144(2):142-8. Epub 2005 Sep 6. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16182389\/\">16182389<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>The central roles of telomeres and subtelomeres in antigenic variation in African trypanosomes.&nbsp;<\/strong>Horn D, Barry JD.&nbsp;<em>Chromosome Res<\/em>. 2005;13(5):525-33. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16132817\/\">16132817<\/a><\/p>\n\n\n\n<p><strong>Vitamin C biosynthesis in trypanosomes: a role for the glycosome.&nbsp;<\/strong>Wilkinson SR, Prathalingam SR, Taylor MC, Horn D, Kelly JM.&nbsp;<em>Proc Natl Acad Sci U S A.<\/em>&nbsp;2005 Aug 16;102(33):11645-50. Epub 2005 Aug 8. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16087875\/\">16087875<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>The genome of the kinetoplastid parasite,&nbsp;<em>Leishmania major.&nbsp;<\/em><\/strong>Ivens AC, Peacock CS, Worthey EA, Murphy L, Aggarwal G, Berriman M, Sisk E, Rajandream MA, Adlem E, Aert R, Anupama A, Apostolou Z, Attipoe P, Bason N, Bauser C, Beck A, Beverley SM, Bianchettin G, Borzym K, Bothe G, Bruschi CV, Collins M, Cadag E, Ciarloni L, Clayton C, Coulson RM, Cronin A, Cruz AK, Davies RM, De Gaudenzi J, Dobson DE, Duesterhoeft A, Fazelina G, Fosker N, Frasch AC, Fraser A, Fuchs M, Gabel C, Goble A, Goffeau A, Harris D, Hertz-Fowler C, Hilbert H, Horn D, Huang Y, Klages S, Knights A, Kube M, Larke N, Litvin L, Lord A, Louie T, Marra M, Masuy D, Matthews K, Michaeli S, Mottram JC, M\u00fcller-Auer S, Munden H, Nelson S, Norbertczak H, Oliver K, O\u2019neil S, Pentony M, Pohl TM, Price C, Purnelle B, Quail MA, Rabbinowitsch E, Reinhardt R, Rieger M, Rinta J, Robben J, Robertson L, Ruiz JC, Rutter S, Saunders D, Sch\u00e4fer M, Schein J, Schwartz DC, Seeger K, Seyler A, Sharp S, Shin H, Sivam D, Squares R, Squares S, Tosato V, Vogt C, Volckaert G, Wambutt R, Warren T, Wedler H, Woodward J, Zhou S, Zimmermann W, Smith DF, Blackwell JM, Stuart KD, Barrell B, Myler PJ.&nbsp;<em>Science.<\/em>&nbsp;2005 Jul 15;309(5733):436-42. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16020728\/\">16020728<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>The genome sequence of&nbsp;<em>Trypanosoma cruzi,<\/em>&nbsp;etiologic agent of Chagas disease.&nbsp;<\/strong>El-Sayed NM, Myler PJ, Bartholomeu DC, Nilsson D, Aggarwal G, Tran AN, Ghedin E, Worthey EA, Delcher AL, Blandin G, Westenberger SJ, Caler E, Cerqueira GC, Branche C, Haas B, Anupama A, Arner E, Aslund L, Attipoe P, Bontempi E, Bringaud F, Burton P, Cadag E, Campbell DA, Carrington M, Crabtree J, Darban H, da Silveira JF, de Jong P, Edwards K, Englund PT, Fazelina G, Feldblyum T, Ferella M, Frasch AC, Gull K, Horn D, Hou L, Huang Y, Kindlund E, Klingbeil M, Kluge S, Koo H, Lacerda D, Levin MJ, Lorenzi H, Louie T, Machado CR, McCulloch R, McKenna A, Mizuno Y, Mottram JC, Nelson S, Ochaya S, Osoegawa K, Pai G, Parsons M, Pentony M, Pettersson U, Pop M, Ramirez JL, Rinta J, Robertson L, Salzberg SL, Sanchez DO, Seyler A, Sharma R, Shetty J, Simpson AJ, Sisk E, Tammi MT, Tarleton R, Teixeira S, Van Aken S, Vogt C, Ward PN, Wickstead B, Wortman J, White O, Fraser CM, Stuart KD, Andersson B.&nbsp;<em>Science.&nbsp;<\/em>2005 Jul 15;309(5733):409-15. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16020725\/\">16020725<\/a>&nbsp;Free Article<\/p>\n\n\n\n<p><strong>Directional enrichment of directly cloned PCR products.&nbsp;<\/strong>Horn D.&nbsp;<em>Biotechniques.<\/em>&nbsp;2005 Jul;39(1):40, 42, 44, 46. No abstract available. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16060367\/\">16060367<\/a>&nbsp;Free Article<\/p>\n\n\n\n<p><strong>Down-regulating gene expression by RNA interference in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Clayton CE, Est\u00e9vez AM, Hartmann C, Alibu VP, Field M, Horn D.&nbsp;<em>Methods Mol Biol.&nbsp;<\/em>2005;309:39-60. No abstract available. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15990397\/\">15990397<\/a><\/p>\n\n\n\n<p><strong>Multiplex analysis of RNA interference defects in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Alsford S, Glover L, Horn D.&nbsp;<em>Mol Biochem Parasitol.<\/em>&nbsp;2005 Jan;139(1):129-32. No abstract available. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15610827\/\">15610827<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>A doubly inducible system for RNA interference and rapid RNAi plasmid construction in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Alibu VP, Storm L, Haile S, Clayton C, Horn D.&nbsp;<em>Mol Biochem Parasitol.<\/em>&nbsp;2005 Jan;139(1):75-82. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15610821\/\">15610821<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2004<\/h4>\n\n\n\n<p><strong>The molecular control of antigenic variation in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Horn D.&nbsp;<em>Curr Mol Med.<\/em>&nbsp;2004 Sep;4(6):563-76. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15357208\/\">15357208<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2003<\/h4>\n\n\n\n<p><strong>Trypanosomatid histones.&nbsp;<\/strong>Alsford S, Horn D.&nbsp;<em>Mol Microbiol.<\/em>&nbsp;2004 Jul;53(2):365-72. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15228519\/\">15228519<\/a>&nbsp;Free Article<\/p>\n\n\n\n<p><strong>RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the african trypanosome.&nbsp;<\/strong>Wilkinson SR, Horn D, Prathalingam SR, Kelly JM.&nbsp;<em>J Biol Chem.<\/em>&nbsp;2003 Aug 22;278(34):31640-6. Epub 2003 Jun 5. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12791697\/\">12791697<\/a>&nbsp;Free Article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2002<\/h4>\n\n\n\n<p><strong>Histone deacetylases in&nbsp;<em>Trypanosoma brucei<\/em>: two are essential and another is required for normal cell cycle progression.&nbsp;<\/strong>Ingram AK, Horn D.&nbsp;<em>Mol Microbiol.<\/em>&nbsp;2002 Jul;45(1):89-97. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12100550\/\">12100550<\/a>&nbsp;Free Article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2001<\/h4>\n\n\n\n<p><strong>Nuclear gene transcription and chromatin in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Horn D.&nbsp;<em>Int J Parasitol.<\/em>&nbsp;2001 Sep;31(11):1157-65. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11513885\/\">11513885<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">2000<\/h4>\n\n\n\n<p><strong>Genetic manipulation indicates that ARD1 is an essential Na-acetyltransferase in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Ingram AK, Cross GA, Horn D.&nbsp;<em>Mol Biochem Parasitol.<\/em>&nbsp;2000 Dec;111(2):309-17. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11163439\/\">11163439<\/a><\/p>\n\n\n\n<p><strong>Telomere maintenance and length regulation in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Horn D, Spence C, Ingram AK.&nbsp;<em>EMBO J.<\/em>&nbsp;2000 May 15;19(10):2332-9. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10811624\/\">10811624<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">1997<\/h4>\n\n\n\n<p><strong>Position-dependent and promoter-specific regulation of gene expression in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Horn D, Cross GA.&nbsp;<em>EMBO J.<\/em>&nbsp;1997 Dec 15;16(24):7422-31. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9405371\/\">9405371<\/a>&nbsp;Free PMC Article<\/p>\n\n\n\n<p><strong>Analysis of&nbsp;<em>Trypanosoma brucei vsg<\/em>&nbsp;expression site switching&nbsp;<em>in vitro.&nbsp;<\/em><\/strong>Horn D, Cross GA.&nbsp;<em>Mol Biochem Parasitol.<\/em>&nbsp;1997 Feb;84(2):189-201. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9084039\/\">9084039<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">1995<\/h4>\n\n\n\n<p><strong>A developmentally regulated position effect at a telomeric locus in&nbsp;<em>Trypanosoma brucei.&nbsp;<\/em><\/strong>Horn D, Cross GA.&nbsp;<em>Cell.<\/em>&nbsp;1995 Nov 17;83(4):555-61. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7585958\/\">7585958<\/a>&nbsp;Free Article<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">1994<\/h4>\n\n\n\n<p><strong>Mice lacking Snrpn expression show normal regulation of neuronal alternative splicing events.&nbsp;<\/strong>Huntriss JD, Barr JA, Horn DA, Williams DG, Latchman DS.&nbsp;<em>Mol Biol Rep.<\/em>&nbsp;1994 Jul;20(1):19-25. Review. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7845394\/\">7845394<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">1993<\/h4>\n\n\n\n<p><strong>The tissue specific SmN protein does not influence the alternative splicing of endogenous N-Cam and C-SRC RNAs in transfected 3T3 cells.&nbsp;<\/strong>Horn DA, Latchman DS.&nbsp;<em>Brain Res Mol Brain Res.&nbsp;<\/em>1993 Aug;19(3):181-7. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8412559\/\">8412559<\/a><\/p>\n\n\n\n<p><strong>A distal region of the CALC-1 gene is necessary for regulated alternative splicing.&nbsp;<\/strong>Horn DA, Latchman DS.&nbsp;<em>FEBS Lett.<\/em>&nbsp;1993 Jun 14;324(2):123-6. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8508914\/\">8508914<\/a>&nbsp;Free Article<\/p>\n\n\n\n<p><strong>Alternative splicing of the mRNA encoding the alpha subunits of the G(o) GTP-binding protein during brain development and in neuronal cell lines.&nbsp;<\/strong>Horn DA, Latchman DS.&nbsp;<em>Neurosci Lett.<\/em>&nbsp;1993 May 28;155(1):57-60. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8361664\/\">8361664<\/a><\/p>\n\n\n\n<p><strong>Expression of the SmN splicing protein is developmentally regulated in the rodent brain but not in the rodent heart.&nbsp;<\/strong>Grimaldi K, Horn DA, Hudson LD, Terenghi G, Barton P, Polak JM, Latchman DS.&nbsp;<em>Dev Biol.<\/em>&nbsp;1993 Apr;156(2):319-23. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8462734\/\">8462734<\/a><\/p>\n\n\n\n<p><strong>The cardiac form of the tissue-specific SmN protein is identical to the brain and embryonic forms of the protein.&nbsp;<\/strong>Gerrelli D, Grimaldi K, Horn D, Mahadeva U, Sharpe N, Latchman DS.&nbsp;<em>J Mol Cell Cardiol.<\/em>&nbsp;1993 Mar;25(3):321-9. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8510173\/\">8510173<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">1992<\/h4>\n\n\n\n<p><strong>Redistribution of secretory granule components precedes that of synaptic vesicle proteins during differentiation of a neuronal cell line in serum-free medium.&nbsp;<\/strong>Wheatley SC, Suburo AM, Horn DA, Vucicevic V, Terenghi G, Polak JM, Latchman DS.&nbsp;<em>Neuroscience.<\/em>&nbsp;1992 Dec;51(3):575-82. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1336820\/\">1336820<\/a><\/p>\n\n\n\n<p><strong>Expression of the tissue specific splicing protein SmN in neuronal cell lines and in regions of the brain with different splicing capacities.&nbsp;<\/strong>Horn DA, Suburo A, Terenghi G, Hudson LD, Polak JM, Latchman DS.&nbsp;<em>Brain Res Mol Brain Res.<\/em>&nbsp;1992 Nov;16(1-2):13-9. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1334191\/\">1334191<\/a><\/p>\n\n\n\n<p><strong>Neuronal expression of the tissue specific splicing protein SmN and its possible role in pre mRNA splicing.&nbsp;<\/strong>Horn DA, Latchman DS.&nbsp;<em>Biochem Soc Trans.<\/em>&nbsp;1992 Aug;20(3):266S. No abstract available. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1426556\/\">1426556<\/a><\/p>\n\n\n\n<p><strong>Intracellular redistribution of neuropeptides and secretory proteins during differentiation of neuronal cell lines.&nbsp;<\/strong>Suburo AM, Wheatley SC, Horn DA, Gibson SJ, Jahn R, Fischer-Colbrie R, Wood JN, Latchman DS, Polak JM.&nbsp;<em>Neuroscience.<\/em>&nbsp;1992;46(4):881-9. PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/1347412\/\">1347412<\/a><\/p>\n<\/div><\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Publications<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-204","page","type-page","status-publish","hentry"],"blocksy_meta":[],"acf":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/david-horn\/wp-json\/wp\/v2\/pages\/204","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/david-horn\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/david-horn\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/david-horn\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/david-horn\/wp-json\/wp\/v2\/comments?post=204"}],"version-history":[{"count":55,"href":"https:\/\/sites.dundee.ac.uk\/david-horn\/wp-json\/wp\/v2\/pages\/204\/revisions"}],"predecessor-version":[{"id":645,"href":"https:\/\/sites.dundee.ac.uk\/david-horn\/wp-json\/wp\/v2\/pages\/204\/revisions\/645"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/david-horn\/wp-json\/wp\/v2\/media?parent=204"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}