{"id":3936,"date":"2017-01-20T15:32:00","date_gmt":"2017-01-20T15:32:00","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=3936"},"modified":"2026-01-26T16:28:05","modified_gmt":"2026-01-26T16:28:05","slug":"ligandability-of-phd-finger-domains-of-baz2a-and-baz2b","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2017\/01\/20\/ligandability-of-phd-finger-domains-of-baz2a-and-baz2b\/","title":{"rendered":"Ligandability of PHD finger domains of BAZ2A and BAZ2B"},"content":{"rendered":"<p><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.7b01093\">Read our Open Access article<\/a><\/p>\n<p>Congratulations to Anastasia, Xavi and colleagues!<\/p>\n<div id='gallery-1' class='gallery galleryid-3936 gallery-columns-3 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Table-of-content-01.png'><img loading=\"lazy\" decoding=\"async\" width=\"683\" height=\"446\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Table-of-content-01.png\" class=\"attachment-large size-large\" alt=\"Table of Graphics\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Table-of-content-01.png 683w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Table-of-content-01-300x196.png 300w\" sizes=\"auto, (max-width: 683px) 100vw, 683px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure1_final-01.png'><img loading=\"lazy\" decoding=\"async\" width=\"852\" height=\"1024\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure1_final-01-852x1024.png\" class=\"attachment-large size-large\" alt=\"Figure 1. Druggable pockets on BAZ2A\/B PHD and validated fragments\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure1_final-01-852x1024.png 852w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure1_final-01-250x300.png 250w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure1_final-01-768x923.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure1_final-01-1278x1536.png 1278w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure1_final-01.png 1544w\" sizes=\"auto, (max-width: 852px) 100vw, 852px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure2-01.png'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"913\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure2-01-1024x913.png\" class=\"attachment-large size-large\" alt=\"Figure 2. Biophysical and structural validation of fragment hits\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure2-01-1024x913.png 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure2-01-300x268.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure2-01-768x685.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure2-01-1536x1370.png 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure2-01.png 1545w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3-01.png'><img loading=\"lazy\" decoding=\"async\" width=\"728\" height=\"1024\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3-01-728x1024.png\" class=\"attachment-large size-large\" alt=\"Figure 3. Insights on the binding mode of optimized fragments.\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3-01-728x1024.png 728w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3-01-213x300.png 213w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3-01-768x1080.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3-01-1092x1536.png 1092w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3-01-1456x2048.png 1456w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3-01.png 1541w\" sizes=\"auto, (max-width: 728px) 100vw, 728px\" \/><\/a>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\n<p><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.7b01093\">Read our Open Access article<\/a><\/p>\n<p>Congratulations to Anastasia, Xavi and colleagues!<\/p>\n<div id='gallery-2' class='gallery galleryid-3936 gallery-columns-3 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Table-of-content-01.png'><img loading=\"lazy\" decoding=\"async\" width=\"683\" height=\"446\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Table-of-content-01.png\" class=\"attachment-large size-large\" alt=\"Table of Graphics\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Table-of-content-01.png 683w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Table-of-content-01-300x196.png 300w\" sizes=\"auto, (max-width: 683px) 100vw, 683px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure1_final-01.png'><img loading=\"lazy\" decoding=\"async\" width=\"852\" height=\"1024\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure1_final-01-852x1024.png\" class=\"attachment-large size-large\" alt=\"Figure 1. Druggable pockets on BAZ2A\/B PHD and validated fragments\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure1_final-01-852x1024.png 852w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure1_final-01-250x300.png 250w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure1_final-01-768x923.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure1_final-01-1278x1536.png 1278w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure1_final-01.png 1544w\" sizes=\"auto, (max-width: 852px) 100vw, 852px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure2-01.png'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"913\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure2-01-1024x913.png\" class=\"attachment-large size-large\" alt=\"Figure 2. Biophysical and structural validation of fragment hits\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure2-01-1024x913.png 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure2-01-300x268.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure2-01-768x685.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure2-01-1536x1370.png 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure2-01.png 1545w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3-01.png'><img loading=\"lazy\" decoding=\"async\" width=\"728\" height=\"1024\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3-01-728x1024.png\" class=\"attachment-large size-large\" alt=\"Figure 3. Insights on the binding mode of optimized fragments.\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3-01-728x1024.png 728w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3-01-213x300.png 213w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3-01-768x1080.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3-01-1092x1536.png 1092w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3-01-1456x2048.png 1456w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3-01.png 1541w\" sizes=\"auto, (max-width: 728px) 100vw, 728px\" \/><\/a>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Read our Open Access article Congratulations to Anastasia, Xavi and colleagues! Read our Open Access article Congratulations to Anastasia, Xavi and colleagues!<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[],"class_list":["post-3936","post","type-post","status-publish","format-standard","hentry","category-19"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/3936","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=3936"}],"version-history":[{"count":2,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/3936\/revisions"}],"predecessor-version":[{"id":4870,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/3936\/revisions\/4870"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=3936"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/categories?post=3936"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/tags?post=3936"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}