{"id":3922,"date":"2025-01-20T15:25:50","date_gmt":"2025-01-20T15:25:50","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=3922"},"modified":"2026-01-26T16:28:46","modified_gmt":"2026-01-26T16:28:46","slug":"refinement-of-the-bump-and-hole-approach","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2025\/01\/20\/refinement-of-the-bump-and-hole-approach\/","title":{"rendered":"Refinement of the \u201cBump-and-Hole\u201d Approach"},"content":{"rendered":"\n<p>Well done for this tour-de-force study to our BBSRC EastBio PhD student&nbsp;Andrew, to Kwok-Ho, Andrea, and to former Lab members Michael, Lars and Matt -with important contributions from our collaborators too!<\/p>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-3 is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Abstract-ChemSci-ac.png\"><img loading=\"lazy\" decoding=\"async\" width=\"939\" height=\"471\" data-id=\"3923\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Abstract-ChemSci-ac.png\" alt=\"ToC Graphics\" class=\"wp-image-3923\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Abstract-ChemSci-ac.png 939w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Abstract-ChemSci-ac-300x150.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Abstract-ChemSci-ac-768x385.png 768w\" sizes=\"auto, (max-width: 939px) 100vw, 939px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f2_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"898\" height=\"1024\" data-id=\"3932\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f2_hi-res-898x1024.jpg\" alt=\"Fig. 2 L\/V mutant characterization\" class=\"wp-image-3932\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f2_hi-res-898x1024.jpg 898w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f2_hi-res-263x300.jpg 263w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f2_hi-res-768x876.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f2_hi-res-1347x1536.jpg 1347w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f2_hi-res-1796x2048.jpg 1796w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f2_hi-res.jpg 2032w\" sizes=\"auto, (max-width: 898px) 100vw, 898px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-s1_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"925\" data-id=\"3931\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-s1_hi-res-1024x925.jpg\" alt=\"Scheme 1 Bumped compound synthesis\" class=\"wp-image-3931\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-s1_hi-res-1024x925.jpg 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-s1_hi-res-300x271.jpg 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-s1_hi-res-768x694.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-s1_hi-res-1536x1388.jpg 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-s1_hi-res.jpg 1767w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f1_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"478\" height=\"1024\" data-id=\"3933\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f1_hi-res-478x1024.jpg\" alt=\"Fig. 1 Bump-&amp;-hole system optimization\" class=\"wp-image-3933\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f1_hi-res-478x1024.jpg 478w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f1_hi-res-140x300.jpg 140w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f1_hi-res-768x1647.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f1_hi-res-716x1536.jpg 716w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f1_hi-res.jpg 952w\" sizes=\"auto, (max-width: 478px) 100vw, 478px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f3_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"904\" height=\"1024\" data-id=\"3930\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f3_hi-res-904x1024.jpg\" alt=\"&quot;Fig. 3 Compound modifications &amp; BRD:ligand co-crystal structures.\" class=\"wp-image-3930\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f3_hi-res-904x1024.jpg 904w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f3_hi-res-265x300.jpg 265w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f3_hi-res-768x869.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f3_hi-res-1357x1536.jpg 1357w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f3_hi-res-1809x2048.jpg 1809w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f3_hi-res.jpg 1892w\" sizes=\"auto, (max-width: 904px) 100vw, 904px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f4_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"722\" height=\"1024\" data-id=\"3929\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f4_hi-res-722x1024.jpg\" alt=\"Fig. 4 Bumped compounds can inhibit single bromodomains and are effective in cells\" class=\"wp-image-3929\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f4_hi-res-722x1024.jpg 722w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f4_hi-res-211x300.jpg 211w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f4_hi-res-768x1090.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f4_hi-res.jpg 974w\" sizes=\"auto, (max-width: 722px) 100vw, 722px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f5_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"628\" height=\"1024\" data-id=\"3928\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f5_hi-res-628x1024.jpg\" alt=\"Fig. 5 Enantiomer Characterization\" class=\"wp-image-3928\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f5_hi-res-628x1024.jpg 628w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f5_hi-res-184x300.jpg 184w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f5_hi-res-768x1253.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f5_hi-res-942x1536.jpg 942w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f5_hi-res.jpg 970w\" sizes=\"auto, (max-width: 628px) 100vw, 628px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f6_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"814\" data-id=\"3927\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f6_hi-res-1024x814.jpg\" alt=\"Fig. 6 (2R,3S)-7: a potent and highly-selective bumped BET inhibitor\" class=\"wp-image-3927\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f6_hi-res-1024x814.jpg 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f6_hi-res-300x239.jpg 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f6_hi-res-768x611.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f6_hi-res-1536x1221.jpg 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f6_hi-res.jpg 2044w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f7_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"654\" height=\"1024\" data-id=\"3926\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f7_hi-res-654x1024.jpg\" alt=\"Fig. 7 (2R,3S)-7 does not perturb WT BET-dependent cells.\" class=\"wp-image-3926\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f7_hi-res-654x1024.jpg 654w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f7_hi-res-192x300.jpg 192w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f7_hi-res-768x1202.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f7_hi-res.jpg 875w\" sizes=\"auto, (max-width: 654px) 100vw, 654px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f8_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"864\" height=\"1024\" data-id=\"3925\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f8_hi-res-864x1024.jpg\" alt=\"Fig. 8 Application of the bump-&amp;-hole system to a biological question\" class=\"wp-image-3925\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f8_hi-res-864x1024.jpg 864w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f8_hi-res-253x300.jpg 253w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f8_hi-res-768x910.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f8_hi-res-1296x1536.jpg 1296w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f8_hi-res-1728x2048.jpg 1728w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f8_hi-res.jpg 1860w\" sizes=\"auto, (max-width: 864px) 100vw, 864px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f9_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"678\" height=\"1024\" data-id=\"3924\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f9_hi-res-678x1024.jpg\" alt=\"Fig. 9 BRD4 and NF-\u03baB-target gene expression\" class=\"wp-image-3924\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f9_hi-res-678x1024.jpg 678w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f9_hi-res-199x300.jpg 199w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f9_hi-res-768x1159.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f9_hi-res.jpg 905w\" sizes=\"auto, (max-width: 678px) 100vw, 678px\" \/><\/a><\/figure>\n<\/figure>\n\n\n\n<p>Well done for this tour-de-force study to our BBSRC EastBio PhD student&nbsp;Andrew, to Kwok-Ho, Andrea, and to former Lab members Michael, Lars and Matt -with important contributions from our collaborators too!<\/p>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-3 is-cropped wp-block-gallery-2 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Abstract-ChemSci-ac.png\"><img loading=\"lazy\" decoding=\"async\" width=\"939\" height=\"471\" data-id=\"3923\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Abstract-ChemSci-ac.png\" alt=\"ToC Graphics\" class=\"wp-image-3923\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Abstract-ChemSci-ac.png 939w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Abstract-ChemSci-ac-300x150.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Abstract-ChemSci-ac-768x385.png 768w\" sizes=\"auto, (max-width: 939px) 100vw, 939px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f2_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"898\" height=\"1024\" data-id=\"3932\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f2_hi-res-898x1024.jpg\" alt=\"Fig. 2 L\/V mutant characterization\" class=\"wp-image-3932\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f2_hi-res-898x1024.jpg 898w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f2_hi-res-263x300.jpg 263w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f2_hi-res-768x876.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f2_hi-res-1347x1536.jpg 1347w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f2_hi-res-1796x2048.jpg 1796w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f2_hi-res.jpg 2032w\" sizes=\"auto, (max-width: 898px) 100vw, 898px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-s1_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"925\" data-id=\"3931\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-s1_hi-res-1024x925.jpg\" alt=\"Scheme 1 Bumped compound synthesis\" class=\"wp-image-3931\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-s1_hi-res-1024x925.jpg 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-s1_hi-res-300x271.jpg 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-s1_hi-res-768x694.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-s1_hi-res-1536x1388.jpg 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-s1_hi-res.jpg 1767w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f1_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"478\" height=\"1024\" data-id=\"3933\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f1_hi-res-478x1024.jpg\" alt=\"Fig. 1 Bump-&amp;-hole system optimization\" class=\"wp-image-3933\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f1_hi-res-478x1024.jpg 478w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f1_hi-res-140x300.jpg 140w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f1_hi-res-768x1647.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f1_hi-res-716x1536.jpg 716w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f1_hi-res.jpg 952w\" sizes=\"auto, (max-width: 478px) 100vw, 478px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f3_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"904\" height=\"1024\" data-id=\"3930\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f3_hi-res-904x1024.jpg\" alt=\"&quot;Fig. 3 Compound modifications &amp; BRD:ligand co-crystal structures.\" class=\"wp-image-3930\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f3_hi-res-904x1024.jpg 904w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f3_hi-res-265x300.jpg 265w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f3_hi-res-768x869.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f3_hi-res-1357x1536.jpg 1357w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f3_hi-res-1809x2048.jpg 1809w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f3_hi-res.jpg 1892w\" sizes=\"auto, (max-width: 904px) 100vw, 904px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f4_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"722\" height=\"1024\" data-id=\"3929\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f4_hi-res-722x1024.jpg\" alt=\"Fig. 4 Bumped compounds can inhibit single bromodomains and are effective in cells\" class=\"wp-image-3929\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f4_hi-res-722x1024.jpg 722w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f4_hi-res-211x300.jpg 211w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f4_hi-res-768x1090.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f4_hi-res.jpg 974w\" sizes=\"auto, (max-width: 722px) 100vw, 722px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f5_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"628\" height=\"1024\" data-id=\"3928\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f5_hi-res-628x1024.jpg\" alt=\"Fig. 5 Enantiomer Characterization\" class=\"wp-image-3928\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f5_hi-res-628x1024.jpg 628w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f5_hi-res-184x300.jpg 184w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f5_hi-res-768x1253.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f5_hi-res-942x1536.jpg 942w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f5_hi-res.jpg 970w\" sizes=\"auto, (max-width: 628px) 100vw, 628px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f6_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"814\" data-id=\"3927\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f6_hi-res-1024x814.jpg\" alt=\"Fig. 6 (2R,3S)-7: a potent and highly-selective bumped BET inhibitor\" class=\"wp-image-3927\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f6_hi-res-1024x814.jpg 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f6_hi-res-300x239.jpg 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f6_hi-res-768x611.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f6_hi-res-1536x1221.jpg 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f6_hi-res.jpg 2044w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f7_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"654\" height=\"1024\" data-id=\"3926\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f7_hi-res-654x1024.jpg\" alt=\"Fig. 7 (2R,3S)-7 does not perturb WT BET-dependent cells.\" class=\"wp-image-3926\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f7_hi-res-654x1024.jpg 654w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f7_hi-res-192x300.jpg 192w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f7_hi-res-768x1202.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f7_hi-res.jpg 875w\" sizes=\"auto, (max-width: 654px) 100vw, 654px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f8_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"864\" height=\"1024\" data-id=\"3925\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f8_hi-res-864x1024.jpg\" alt=\"Fig. 8 Application of the bump-&amp;-hole system to a biological question\" class=\"wp-image-3925\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f8_hi-res-864x1024.jpg 864w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f8_hi-res-253x300.jpg 253w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f8_hi-res-768x910.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f8_hi-res-1296x1536.jpg 1296w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f8_hi-res-1728x2048.jpg 1728w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f8_hi-res.jpg 1860w\" sizes=\"auto, (max-width: 864px) 100vw, 864px\" \/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f9_hi-res.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"678\" height=\"1024\" data-id=\"3924\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f9_hi-res-678x1024.jpg\" alt=\"Fig. 9 BRD4 and NF-\u03baB-target gene expression\" class=\"wp-image-3924\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f9_hi-res-678x1024.jpg 678w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f9_hi-res-199x300.jpg 199w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f9_hi-res-768x1159.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/c7sc02536j-f9_hi-res.jpg 905w\" sizes=\"auto, (max-width: 678px) 100vw, 678px\" \/><\/a><\/figure>\n<\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Well done for this tour-de-force study to our BBSRC EastBio PhD student&nbsp;Andrew, to Kwok-Ho, Andrea, and to former Lab members Michael, Lars and Matt -with important contributions from our collaborators too! Well done for this tour-de-force study to our BBSRC EastBio PhD student&nbsp;Andrew, to Kwok-Ho, Andrea, and to former Lab members Michael, Lars and Matt [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[],"class_list":["post-3922","post","type-post","status-publish","format-standard","hentry","category-19"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/3922","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=3922"}],"version-history":[{"count":4,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/3922\/revisions"}],"predecessor-version":[{"id":4893,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/3922\/revisions\/4893"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=3922"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/categories?post=3922"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/tags?post=3922"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}