{"id":3902,"date":"2017-01-20T14:50:00","date_gmt":"2017-01-20T14:50:00","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=3902"},"modified":"2026-01-28T09:54:31","modified_gmt":"2026-01-28T09:54:31","slug":"first-crystal-structure-of-the-vhl-elobc-cul2-rbx1-multi-subunit-complex","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2017\/01\/20\/first-crystal-structure-of-the-vhl-elobc-cul2-rbx1-multi-subunit-complex\/","title":{"rendered":"First crystal structure of the VHL-EloBC-Cul2-Rbx1 multi-subunit complex"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0969212617301272?via%3Dihub\">Read our article open access<\/a><\/p>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-4 is-cropped brgr gallery wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" data-id=\"3903\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/GraphicalAbstract-300dpi-1024x1024.jpg\" alt=\"Graphical Abstract\" class=\"wp-image-3903\"\/><figcaption class=\"wp-element-caption\">Graphical Abstract<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" data-id=\"3907\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure1_2-885x1024.jpg\" alt=\"Figure 1. Crystal Structure of the CRL2VHL Complex\" class=\"wp-image-3907\"\/><figcaption class=\"wp-element-caption\">Figure 1. Crystal Structure of the CRL2VHL Complex<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" data-id=\"3904\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure2_1.jpg\" alt=\"Figure 2. The CRL2VHL Complex Is Dynamic and Flexible\" class=\"wp-image-3904\"\/><figcaption class=\"wp-element-caption\">Figure 2. The CRL2VHL Complex Is Dynamic and Flexible<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" data-id=\"3910\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure3_1.jpg\" alt=\"Figure 3. Rbx1 Presents a New Orientation\" class=\"wp-image-3910\"\/><figcaption class=\"wp-element-caption\">Figure 3. Rbx1 Presents a New Orientation<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" data-id=\"3908\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure4_1-1024x584.jpg\" alt=\"Figure 4. The Cul2-VBC Interface&quot; title=&quot;Figure 4. The Cul2-VBC Interface\" class=\"wp-image-3908\"\/><figcaption class=\"wp-element-caption\">Figure 4. The Cul2-VBC Interface&#8221; title=&#8221;Figure 4. The Cul2-VBC Interface<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" data-id=\"3905\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure5_0-1024x595.jpg\" alt=\"Figure 5. Biophysical Characterization of the Interaction between VBC and Cul2\" class=\"wp-image-3905\"\/><figcaption class=\"wp-element-caption\">Figure 5. Biophysical Characterization of the Interaction between VBC and Cul2<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" data-id=\"3909\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure6_0-1024x460.jpg\" alt=\"Figure6. Residues in the EloC Hydrophobic Pocket Reveal Criticality for the Strong Binding Affinity of Cul2-VBC\" class=\"wp-image-3909\"\/><figcaption class=\"wp-element-caption\">Figure6. Residues in the EloC Hydrophobic Pocket Reveal Criticality for the Strong Binding Affinity of Cul2-VBC<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" data-id=\"3906\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure7_0-1024x551.jpg\" alt=\"Figure 7. Swapping Residues and Selectivity for Cul2 or Cul5\" class=\"wp-image-3906\"\/><figcaption class=\"wp-element-caption\">Figure 7. Swapping Residues and Selectivity for Cul2 or Cul5<\/figcaption><\/figure>\n<\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Read our article open access<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[],"class_list":["post-3902","post","type-post","status-publish","format-standard","hentry","category-19"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":7}},"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/3902","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=3902"}],"version-history":[{"count":1,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/3902\/revisions"}],"predecessor-version":[{"id":4955,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/3902\/revisions\/4955"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=3902"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/categories?post=3902"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/tags?post=3902"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}